Hyperbaric Oxygen Therapy - Hyperbaric Chamber Information ...
Hyperbaric Oxygen Therapy - Hyperbaric Chamber Information ...
Hyperbaric Oxygen Therapy - Hyperbaric Chamber Information ...
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The study by Sawin et al 55 was distinctly different from the others since the subjects were<br />
neonates. In the other two studies the mean age of participants was above 45 years.<br />
Study quality<br />
Most of the studies failed to provide any information about masking procedures, except<br />
Sawin et al55 in which no masking was done. All studies reported complete follow-up of<br />
subjects (Table 27).<br />
Table 27 Methodological quality of included studies focusing on the use of HBOT in necrotising<br />
fasciitis.<br />
First Author and<br />
Year of Publication<br />
Patient criteria<br />
Study Design Randomisation Masking Losses to Follow-up<br />
Shupak 1995 54 Comparative study None Unclear No losses<br />
Sawin 1994 55 Comparative study None None No losses<br />
Barzilai 1985 56 Comparative study None Unclear No losses<br />
Inclusion criteria were defined on the basis of a clinical diagnosis of necrotising fasciitis<br />
based on signs and symptoms (Table 28). No attempts at standardisation were made.<br />
Table 28 Patient criteria of included studies focusing on the use of HBOT in necrotising fasciitis.<br />
First Author and<br />
Year of Publication<br />
Patient Criteria<br />
Shupak 1995 54 Patients diagnosed with necrotising fasciitis.<br />
Sawin 1994 55 Neonates diagnosed with necrotising fasciitis of the abdominal wall.<br />
Barzilai 1985 56 Patients diagnosed with necrotising fasciitis.<br />
Interventions examined<br />
All comparison therapies consisted of surgical debridement, broad spectrum antibiotics,<br />
and dressings (Table 29). Surgical debridement was described as “aggressive,” and<br />
antibiotic regimens were modified following the results of microbial sensitivity.<br />
In two of the studies, 55,56 HBOT was not described in adequate detail. No description<br />
was given of the pressures to which subjects were exposed or the frequency, duration,<br />
and total period of therapy.<br />
36 <strong>Hyperbaric</strong> oxygen therapy