Hyperbaric Oxygen Therapy - Hyperbaric Chamber Information ...
Hyperbaric Oxygen Therapy - Hyperbaric Chamber Information ...
Hyperbaric Oxygen Therapy - Hyperbaric Chamber Information ...
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Table 15 Therapeutic protocols used in intervention and comparison groups in included studies<br />
focusing on the use of HBOT in thermal burns.*<br />
First Author and<br />
Year of Publication<br />
Brannen 1997 38<br />
Niezgoda 1997 39<br />
Hammarlund 1991 40<br />
Cianci 1990 41<br />
Gorman 1988 42<br />
Niu 1987 43<br />
Waisbren 1982 44<br />
Hart 1974 45<br />
Intervention Group Comparison Group<br />
n=63<br />
Comparison therapy plus treatment in an<br />
unstated chamber HBO device using 100%<br />
oxygen at 2 ATA for 90 minutes twice a day for<br />
at least 10 treatments and a maximum of 1<br />
treatment per percent total body surface area<br />
burn.<br />
n=6<br />
Placement in a multiplace HBO chamber using<br />
oxygen at 2.4 ATA for 30 minutes twice a day<br />
for 3 days.<br />
n=9<br />
Placement in a multiplace HBO chamber at<br />
1.5, 10.5, and 21.5 hours after injury at<br />
approximately 2.8 ATA for 1 hour.<br />
n=10<br />
Comparison therapy plus treatment in a<br />
monoplace chamber HBO device at 2 ATA for<br />
90 minutes twice a day. Alpha-tocopherol (400<br />
units) as seizure prophylaxis.<br />
n=67<br />
Comparison therapy plus HBOT. †<br />
n=266<br />
Comparison therapy plus treatment in a<br />
monoplace chamber HBO device. For adults,<br />
exposure was to 2.5 ATA for 90-120 minutes,<br />
two to three times a day. For children,<br />
exposure was to 2 ATA for 60 minutes one to<br />
two time a day.<br />
n=36<br />
HBOT not described.<br />
n=8<br />
Comparison therapy plus treatment in a<br />
monoplace HBO chamber with 100% oxygen<br />
at 2 ATA for 90 minutes every 8 hours for 24<br />
hours, then every 12 hours until healed.<br />
* Abbreviations: ATA = atmosphere absolute, n = sample size<br />
† <strong>Therapy</strong> not described.<br />
n=62<br />
Conventional therapy. †<br />
n=6<br />
Placement in a multiplace HBO chamber using<br />
air at 2.4 ATA for 30 minutes twice a day for 3<br />
days.<br />
n=9<br />
No treatment.<br />
n=11<br />
Burn therapy protocol. †<br />
n=113<br />
Conventional surgical care. †<br />
n=609<br />
Colloid, debridement, dressing.<br />
n=36<br />
<strong>Therapy</strong> not described.<br />
n=8<br />
Buffered Ringer’s lactate, colloid, or blood as<br />
needed. Silver sulfadiazine, vitamin B complex<br />
three times a day, alpha-tocopherol four times<br />
a day, vitamin C, antibiotics for the first 96<br />
hours. Escharotomy or tracheostomy as<br />
needed.<br />
Sham treatment in a monoplace HBO<br />
chamber.<br />
The frequency and duration of exposure were equally variable. In the clinical studies,<br />
duration of exposure ranged from 30-90 minutes, while daily to three-times daily<br />
exposures were used. Some studies explicitly mentioned maximum exposure times, while<br />
others employed HBOT until lesions were healed.<br />
The disparities in intervention protocols were reflected in equally varied comparison<br />
protocols. In three studies 39,43,45 comparison therapies were described, but only two<br />
22 <strong>Hyperbaric</strong> oxygen therapy