Prime User Manual - ISP
Prime User Manual - ISP
Prime User Manual - ISP
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<strong>Prime</strong> <strong>User</strong> <strong>Manual</strong><br />
Chapter 6: Fold Recognition<br />
Chapter 6<br />
When sequence searches in the Find Homologs step of <strong>Prime</strong>–SP fail to find templates, or<br />
query-template sequence identity is low, structure prediction may be continued using the<br />
Threading path. The Threading path involves use of Fold Recognition to find candidate “seed”<br />
templates, followed by a return to the Comparative Modeling path with a selection of<br />
templates. Fold recognition is not available on Windows.<br />
6.1 Overview of the Fold Recognition Step<br />
The Fold Recognition step is designed to find structural templates that could not be found by a<br />
sequence search. The use of secondary structure matching is important in finding remote<br />
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