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Prime User Manual - ISP

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24<br />

Chapter 3: <strong>Prime</strong>–Structure Prediction: Initial Steps<br />

<strong>Prime</strong> 2.1 <strong>User</strong> <strong>Manual</strong><br />

Figure 3.5. The Find Homologs step with search results.<br />

If structure alignment fails or does not give the intended result, the problem may be one of the<br />

following:<br />

• The selected templates are structurally too dissimilar for a meaningful alignment.<br />

• One or more of the template structures includes multiple chains, and either<br />

• Two or more templates are chains from one .pdb file (the structure alignment facility<br />

will not align chains from the same file), or<br />

• The chains that were aligned were not the chains you intended to align.

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