Protoplasmic Movement and Quinine. - Journal of Cell Science
Protoplasmic Movement and Quinine. - Journal of Cell Science
Protoplasmic Movement and Quinine. - Journal of Cell Science
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682 PEOFESSOB DR. E. BINZ.<br />
<strong>Protoplasmic</strong> <strong>Movement</strong> <strong>and</strong> <strong>Quinine</strong>.<br />
By<br />
Pr<strong>of</strong>. Dr. E. Blnz,<br />
ill Bonn.<br />
IN NO. XCV <strong>of</strong> this <strong>Journal</strong>, July, 1884, p. 396, the following<br />
sentence occurs in the translation <strong>of</strong> the treatise <strong>of</strong> Pr<strong>of</strong>essor<br />
Engelmann in Utrecht from L. Hermann's 'H<strong>and</strong>book <strong>of</strong><br />
Physiology :'<br />
"Binz 1 <strong>and</strong> others have observed that quinine exercises a<br />
strongly destructive action on many kinds <strong>of</strong> protoplasm <strong>and</strong><br />
on colourless blood-corpuscles. On the other h<strong>and</strong>, I have<br />
given frogs such large doses <strong>of</strong> quinine sulphate by subcutaneous<br />
injection as to kill them, <strong>and</strong> have observed the lymphcorpuscles<br />
after some hours in active movement."<br />
My pupil, C. Scharrenbroich, now physician in Pallanza, has<br />
already published a reply to this statement <strong>of</strong> Engelmann. 2<br />
He has shown that the discordant statement <strong>of</strong> Engelmann<br />
rests on two reasons : on a different manner <strong>of</strong> making the<br />
experiment I describe, <strong>and</strong> on a false interpretation <strong>of</strong> the<br />
stunted movements which Engelmann still saw in the colourless<br />
blood-corpuscles <strong>of</strong> his frogs. Pr<strong>of</strong>essor Engelmann was good<br />
enough soon afterwards to write me as follows:<br />
1 C. Binz, " Ueber die Einwiiknng des Chinin auf Protoplasmabewegung,"<br />
'Arch. f. mikrosk. Anat.,' iii, p. 383, 1867.<br />
* " Einiges Alte fiber Chinin," ' Arch. f. Pathol. u. Pharmakol.,' xii, p. 33<br />
1879.
PROTOPLASMIC MOVEMENT AND QUININE. 683<br />
" UTRECHT, June 2Ltf, 1880.<br />
" DEAH COLLEAGUE,—Allow me to add a few words to the<br />
dissertation <strong>of</strong> my pupil, C. ten Bosch, on Chinamine, which<br />
.1 sent to you to-day. As you will see from the work, in case<br />
the Dutch does not prevent you from reading it, I have made<br />
comparative researches with C. ten Bosch on the action <strong>of</strong><br />
Chinamine <strong>and</strong> <strong>Quinine</strong> on elementary organisms, especially<br />
on white blood-corpuscles, <strong>and</strong> have thereby had opportunity<br />
to confirm your important results as to the extremely intense<br />
action <strong>of</strong> quinine on contractile blood-cells, also to<br />
verify the superiority <strong>of</strong> this body to Chinamine, which in other<br />
respects far exceeds the action <strong>of</strong> <strong>Quinine</strong>.<br />
" I am glad thus to clear away a little mistake which I<br />
have caused through my over-sceptical remarks in L. Hermann's<br />
' H<strong>and</strong>book' (art., " <strong>Protoplasmic</strong> <strong>Movement</strong>"). If<br />
I can render you a service thereby I will gladly publish a<br />
notice as to the settlement <strong>of</strong> this difference anywhere you<br />
think suitable, perhaps in continuation <strong>of</strong> Dr. Scharrenbroich's<br />
article.<br />
" Of course the remarks as to <strong>Quinine</strong> will be altered in a<br />
possible second edition <strong>of</strong> the first volume <strong>of</strong> Hermann's<br />
* H<strong>and</strong>book.' The fact on which my sceptical remarks rest is<br />
beyond doubt, but it cannot form the basis <strong>of</strong> an objection to<br />
your statements. I am, &c, yours,<br />
" TH. W. ENGELMANN."<br />
" To Pr<strong>of</strong>. Dr. BINZ, Bonn."<br />
It appears to me that the matter is thus settled. But should<br />
anyone wish for further confirmation <strong>of</strong> what I have published<br />
on the influence <strong>of</strong> quinine on protoplasm in the above quoted<br />
<strong>and</strong> in later papers, I would refer to the following:<br />
(1) G. Kerner, ' Arch. f. d. ges. Physiologie,' iii, p. 136,<br />
tab. ii, v, p. 27; vii, p. 135, 1870—1873.<br />
(2) Buchanan Baxter, ' The Practitioner,' a journal for<br />
therapeutics <strong>and</strong> public health, London, xi, p. 324, 1873.
684 PROFESSOR DR. E. BINZ.<br />
(3) Ch. Darwin, ' Insectivorous Plants/ London, 1875, pp.<br />
201—203.<br />
(4) T. Appert, ' Arch. f. pathol. Anatomie/ lxxi, p. 364,<br />
1877 (from Pr<strong>of</strong>essor Arnold's laboratory, Heidelberg).<br />
(5) C. Fr. W. Krukenberg, ' Vergleichend. physiolog.<br />
Studien,' Heidelberg, 1880, i, p. 8.