Investigation and Management of Chronic Lymphocytic Leukemia

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Rai Staging for CLL Stage Modified Stage Features Median Survival (yrs) 0 Low-risk Lymphocytosis >10 I II III IV Intermediate-Risk Lymphadenopathy Splenomegaly High-Risk Hgb
Anemia/Thrombocytopenia in CLL 24% <strong>of</strong> patients developed cytopenia at some point in their disease 50% = marrow failure 20% = autoimmune (AID) 30% = “other”, eg, iron deficiency, uremia AID: frequency in decreasing order AIHA ITP Red cell aplasia Autoimmune neutropenia Zent et al. Br J Haematol, 141:615, 2008
Page 1 and 2: Investigation and Management of Chr
Page 3 and 4: Types of Lymphoproliferative Diseas
Page 5 and 6: Chronic B Cell Disorders & Flow Cyt
Page 7: Relevance of MBL? MBL 1%/year CLL L
Page 11 and 12: Predicting Disease Progression Mark
Page 13 and 14: Other Investigations Routine bioch
Page 15 and 16: Approaches to Initial Treatment Amo
Page 17 and 18: CLL8 Study Design and Treatment Unt
Page 19 and 20: Adverse Events Total number of pati
Page 21 and 22: Progression-Free Survival Binet B/F
Page 23 and 24: Prognostic Markers Hallek et al. La
Page 25 and 26: Standard Treatments Reference Treat
Page 27 and 28: Complications of CLL Most deaths r
Page 29 and 30: Risk of AIHA with Chemotherapy 739
Page 31 and 32: What Rai Stage does he have? 1. Rai
Page 33 and 34: You would tell patient 1. “Don’
Page 35 and 36: You would order 1. Hemolytic anemia
Page 37 and 38: Significance of Direct Antiglobulin
Page 39 and 40: In 3 months CBC Lymphocytes 87 x
Page 41 and 42: Patient course Patient treated wit
Page 43 and 44: Incidence of immune cytopenias afte
Page 45 and 46: Survival Borthakur et al. BJH, 136:
Page 47 and 48: Case #2 56 yr of man has a routine
Page 49: Patient turns out to have a colon c

Investigation and Management of Chronic Lymphocytic Leukemia

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