Investigation and Management of Chronic Lymphocytic Leukemia

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Treatment of AID Initially prednisone 1 mg/kg Septra DS 1 tab po BID at weekends Pamidronate 30 mg iv every 3 months If unable to wean off, then add in cyclosporine or cyclophosphamide If have active disease or unresponsive to above give CRD
Risk of AIHA with Chemotherapy 739 pts CLB FLU FC FCR (300 pt) Developed AIHA 12% 11% 5% 6.5% Dearden et al. Blood, 111:1820, 2008 Borthakur et al. BJH, 136:800, 2007
Page 1 and 2: Investigation and Management of Chr
Page 3 and 4: Types of Lymphoproliferative Diseas
Page 5 and 6: Chronic B Cell Disorders & Flow Cyt
Page 7 and 8: Relevance of MBL? MBL 1%/year CLL L
Page 9 and 10: Anemia/Thrombocytopenia in CLL 24%
Page 11 and 12: Predicting Disease Progression Mark
Page 13 and 14: Other Investigations Routine bioch
Page 15 and 16: Approaches to Initial Treatment Amo
Page 17 and 18: CLL8 Study Design and Treatment Unt
Page 19 and 20: Adverse Events Total number of pati
Page 21 and 22: Progression-Free Survival Binet B/F
Page 23 and 24: Prognostic Markers Hallek et al. La
Page 25 and 26: Standard Treatments Reference Treat
Page 27: Complications of CLL Most deaths r
Page 31 and 32: What Rai Stage does he have? 1. Rai
Page 33 and 34: You would tell patient 1. “Don’
Page 35 and 36: You would order 1. Hemolytic anemia
Page 37 and 38: Significance of Direct Antiglobulin
Page 39 and 40: In 3 months CBC Lymphocytes 87 x
Page 41 and 42: Patient course Patient treated wit
Page 43 and 44: Incidence of immune cytopenias afte
Page 45 and 46: Survival Borthakur et al. BJH, 136:
Page 47 and 48: Case #2 56 yr of man has a routine
Page 49: Patient turns out to have a colon c

Investigation and Management of Chronic Lymphocytic Leukemia

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