Investigation and Management of Chronic Lymphocytic Leukemia

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Clinical Trials in CLL Clinic Younger patients FCR vs FR vs FR + lenalidomide Older patients CLB vs CLB + rituximab vs CLB + RO5072759 Resistant patients Fludarabine plus valproic acid
Complications <strong>of</strong> CLL Most deaths related to: Progressive CLL, including Richter’s transformation Second malignancies Infections Autoimmune problems: 10-20% autoimmune cytopenias AIHA, ITP, autoimmune neutropenia, aplastic anemia Nephrotic syndrome
Page 1 and 2: Investigation and Management of Chr
Page 3 and 4: Types of Lymphoproliferative Diseas
Page 5 and 6: Chronic B Cell Disorders & Flow Cyt
Page 7 and 8: Relevance of MBL? MBL 1%/year CLL L
Page 9 and 10: Anemia/Thrombocytopenia in CLL 24%
Page 11 and 12: Predicting Disease Progression Mark
Page 13 and 14: Other Investigations Routine bioch
Page 15 and 16: Approaches to Initial Treatment Amo
Page 17 and 18: CLL8 Study Design and Treatment Unt
Page 19 and 20: Adverse Events Total number of pati
Page 21 and 22: Progression-Free Survival Binet B/F
Page 23 and 24: Prognostic Markers Hallek et al. La
Page 25: Standard Treatments Reference Treat
Page 29 and 30: Risk of AIHA with Chemotherapy 739
Page 31 and 32: What Rai Stage does he have? 1. Rai
Page 33 and 34: You would tell patient 1. “Don’
Page 35 and 36: You would order 1. Hemolytic anemia
Page 37 and 38: Significance of Direct Antiglobulin
Page 39 and 40: In 3 months CBC Lymphocytes 87 x
Page 41 and 42: Patient course Patient treated wit
Page 43 and 44: Incidence of immune cytopenias afte
Page 45 and 46: Survival Borthakur et al. BJH, 136:
Page 47 and 48: Case #2 56 yr of man has a routine
Page 49: Patient turns out to have a colon c

Investigation and Management of Chronic Lymphocytic Leukemia

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