Investigation and Management of Chronic Lymphocytic Leukemia

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Treatments for CLL in Manitoba Fit (CIRS ≤6) FCR Less fit FR High-dose solumedrol Campath-1 Marrow transplant (
St<strong>and</strong>ard Treatments Reference Treatment Number Previous Treatment CR (%) nPR (%) PR (%) Keating et al FCR 224 No 70 10 15 Weirda et al FCR 177 Yes 25 16 32 Hallek et al FCR 388 No 44 - 51 FC 371 No 22 - 67 Byrd et al FR 104 38 - 46 Kay et al PCR 64 41 22 28 95% 73%
Page 1 and 2: Investigation and Management of Chr
Page 3 and 4: Types of Lymphoproliferative Diseas
Page 5 and 6: Chronic B Cell Disorders & Flow Cyt
Page 7 and 8: Relevance of MBL? MBL 1%/year CLL L
Page 9 and 10: Anemia/Thrombocytopenia in CLL 24%
Page 11 and 12: Predicting Disease Progression Mark
Page 13 and 14: Other Investigations Routine bioch
Page 15 and 16: Approaches to Initial Treatment Amo
Page 17 and 18: CLL8 Study Design and Treatment Unt
Page 19 and 20: Adverse Events Total number of pati
Page 21 and 22: Progression-Free Survival Binet B/F
Page 23: Prognostic Markers Hallek et al. La
Page 27 and 28: Complications of CLL Most deaths r
Page 29 and 30: Risk of AIHA with Chemotherapy 739
Page 31 and 32: What Rai Stage does he have? 1. Rai
Page 33 and 34: You would tell patient 1. “Don’
Page 35 and 36: You would order 1. Hemolytic anemia
Page 37 and 38: Significance of Direct Antiglobulin
Page 39 and 40: In 3 months CBC Lymphocytes 87 x
Page 41 and 42: Patient course Patient treated wit
Page 43 and 44: Incidence of immune cytopenias afte
Page 45 and 46: Survival Borthakur et al. BJH, 136:
Page 47 and 48: Case #2 56 yr of man has a routine
Page 49: Patient turns out to have a colon c

Investigation and Management of Chronic Lymphocytic Leukemia

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