SURGICAL ANTIBIOTIC PROPHYLAXIS

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<strong>ANTIBIOTIC</strong> USE • Oral prophylactic regimen to decrease bacterial colonization for elective colo-rectal surgery. – Mechanical bowel preparation - Use of Go-Lytely – Oral antibiotics - Erythromycin base and neomycin 1gm PO @ 1pm, 2pm and 11pm (for an 8 am surgery or 19, 18 and 9 hours preop – This regimen in addition to IV antibiotics (cefoxitin or cefotetan) further reduces risk of post-operative infection
<strong>ANTIBIOTIC</strong> USE • Timing of antibiotic administration – It is clear that antimicrobial prophylaxis is effective when administered prior to the first incision. - Antibiotic must be present in adequate concentrations in the tissues when bacterial contamination occurs. - Administration within 30-60 minutes of incision – Adequate antibiotic concentrations must be maintained throughout the surgical procedure - Dependent upon the length of surgery and antibiotic half-life - Redose antibiotic if surgical procedure exceeds 2 half-lives of drug utilized
Page 1 and 2: SURGICAL ANTIBIOTIC PROPHYLAXIS Ste
Page 3 and 4: INTRODUCTION • Approximately 23 m
Page 5 and 6: INTRODUCTION • Controversies rega
Page 7 and 8: DEFINITIONS • Surgical wound infe
Page 9 and 10: WOUND CLASSIFICATION • Clean - SW
Page 11 and 12: WOUND CLASSIFICATION • Contaminat
Page 13 and 14: IDENTIFIED RISK FACTORS • Inciden
Page 15 and 16: ASA RISK FACTORS Class Description
Page 17 and 18: RISK FACTORS • Surgery related fa
Page 19 and 20: ANTIBIOTICS USE Procedure Open Hear
Page 21 and 22: ANTIBIOTIC USE • Appropriate anti
Page 23 and 24: ANTIBIOTIC SELECTION • Nose - S.
Page 25 and 26: ANTIBIOTIC SELECTION • Cefazolin
Page 27 and 28: ANTIBIOTIC SELECTION • Surgical p
Page 29: ANTIBIOTIC SELECTION • Bacterial
Page 33 and 34: ENDOCARDITIS PROPHYLAXIS • Patien
Page 35 and 36: SUMMARY • Surgical prophylaxis ca
Page 37 and 38: SUMMARY • Several risk factors co

SURGICAL ANTIBIOTIC PROPHYLAXIS

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