2012 Promega catalogue
2012 Promega catalogue
2012 Promega catalogue
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Life<br />
Science<br />
Catalog<br />
<strong>2012</strong><br />
Worldwide Contact List<br />
Section<br />
Contents<br />
Table of<br />
Contents<br />
Cell Signaling<br />
Drug Discovery Solutions<br />
Harnessing the Power of Bioluminescence for<br />
Biochemical & Cell-Based Assays<br />
Today’s drug development needs are mature and<br />
complex. Instead of targets, biology & workflow<br />
are key elements. Drug developers in academia and<br />
industry alike need assays that are sensitive, robust,<br />
scalable, and easy to use, all that fit their workflows<br />
while maintaining physiological relevance.<br />
No single assay can be applied to all phases of drug<br />
discovery but <strong>Promega</strong> has developed key platform<br />
technologies based on luminescence and fluorescence<br />
that can be applied across the discovery spectrum.<br />
From the well-defined biochemical assay to a<br />
phenotypic/’black box’ assay using genetic reporter<br />
assays, drug discovery assays span a complex spectrum<br />
of critical parameters and key deliverables.<br />
<strong>Promega</strong> continues to offer solutions that enable you<br />
to develop better drugs, faster:<br />
• Better profiling data<br />
• More biologically relevant data<br />
• Multiplexing solutions for increased understanding<br />
of biology<br />
• Custom Assay Services (CAS@promega.com)<br />
Starting with a single, well-defined biological reaction,<br />
we have developed a solid technology platform from<br />
which hundreds of unique in vitro biochemical & cellbased<br />
assays have been configured.<br />
On the following pages are multiple robust & validated<br />
assays for many early drug discovery needs. And if<br />
what you are looking for isn’t here, let us partner with<br />
you to develop a custom solution.<br />
136<br />
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VIABLE<br />
<br />
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<br />
NECROSIS<br />
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REDUCED VIABILITY<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
S<br />
N<br />
S<br />
N<br />
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APOPTOSIS<br />
For complete and up-to-date product information visit: www.promega.com/catalog<br />
<br />
Custom Assay Services<br />
Biology-driven, <strong>Promega</strong> technology-enabled<br />
custom solutions for :<br />
• Cell Engineering<br />
• Assay Development & Qualification<br />
• Assay-Ready Cells In-Scale<br />
www.promega.com/CAS/<br />
Reporter gene assays<br />
HO<br />
Proliferation/viability assays<br />
HO<br />
Cellular enzymatic assays<br />
Protease HO S<br />
Z-DEVD–N<br />
H<br />
N<br />
S S<br />
proluciferin<br />
9541MA<br />
<br />
luciferase<br />
N COOH + ATP<br />
Glo<br />
S<br />
ATP<br />
ATP ATP<br />
ATP ATP<br />
Lyse Cell<br />
Ultra-Glo<br />
N COOH + ATP<br />
Glo<br />
rLuciferase<br />
S<br />
N S<br />
N<br />
CO2H<br />
Promoter<br />
N COOH<br />
+ ATP<br />
luc<br />
Ultra-Glo<br />
rLuciferase<br />
Glo
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