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<strong>IMS</strong> COM PANY PRO FILES NOVARTIS<br />
<strong>Company</strong>/Organization Date Area of<br />
Collaboration<br />
Terms of Agreement<br />
Immusol 2005 Target identification Three-year discovery, development and<br />
commercialization agreement to use<br />
Immusol’s gene-activation technology to<br />
discover targets, which Novartis might<br />
elect to use for the development of<br />
pharmaceuticals.<br />
Avalon 2005 Drug discovery Agreement to develop small-molecule<br />
drug using Avalon’s drug-discovery engine<br />
and product candidates in Novartis’<br />
chemical library. Milestone achieved in<br />
January 2008.<br />
Immusol 2005 Drug discovery Three-year discovery, development and<br />
commercialization collaboration. Immusol<br />
will leverage its gene activation technology<br />
to discover biologically validated drug<br />
targets for Novartis.<br />
Idera (formerly Hybridon) 2005 Drug discovery Research collaboration and license deal for<br />
the discovery, optimization, development<br />
and commercialization of Toll-like receptor<br />
9 drug candidates targeting asthma and<br />
allergy based on Hybridon’s proprietary<br />
immune modulatory oligonucleotide (IMO)<br />
technology platform.<br />
Galapagos 2005 Design research<br />
programs<br />
Agreement to use Galapagos’ genomics<br />
services division’s SilenceSelect target<br />
discovery system.<br />
Conor Medsystems 2005 Drug-coated stents Conor will test three Novartis products<br />
(Glivec, Elidel and midostaurin) for use<br />
with future stents for the treatment of<br />
clogged heart arteries. If one of the<br />
compounds proves successful, Conor has<br />
the option to obtain a worldwide,<br />
non-exclusive license to commercialize<br />
products combining the compound and its<br />
stents.<br />
© 2009 <strong>IMS</strong> Health In cor po rated or its af fil i ates Page 134