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<strong>IMS</strong> COM PANY PRO FILES NOVARTIS<br />
<strong>Company</strong>/Organization Date Area of<br />
Collaboration<br />
Terms of Agreement<br />
ProMetic Biosciences 2006 Vaccines Agreement to develop synthetic-ligand<br />
affinity adsorbent for the purification of a<br />
recombinant protein vaccine. ProMetic will<br />
receive funding from Novartis. Financial<br />
details were not disclosed.<br />
Entelos 2006 Drug development Research in multiple disease areas.<br />
Novartis will provide R&D funding, while<br />
Entelos will conduct biosimulation<br />
research, which predicts the effects of<br />
drugs using “virtual patients”. The<br />
technology will provide more information<br />
for Novartis’ drug development, including<br />
the design of phase III clinical trial design.<br />
Financial terms were not disclosed.<br />
Momenta 2006 Biosimilars Agreement between Sandoz and Momenta<br />
to develop four follow-on and complex<br />
generic versions of previously approved<br />
recombinant biotechnology and complex<br />
drugs. Sandoz will make an initial<br />
payment of $75m for the purchase of<br />
approximately 4.7m shares of Momenta,<br />
which is also eligible to receive up to<br />
$188m in additional payments if all<br />
milestones are achieved.<br />
Cytopia 2006 Drug discovery Global license and R&D collaboration to<br />
develop orally active, small molecules<br />
therapeutics targeting JAK3 kinases for<br />
the prevention of transplant rejection and<br />
the treatment of multiple indications in<br />
autoimmune diseases such as rheumatoid<br />
arthritis. Novartis will assume<br />
responsibility for product development and<br />
commercialization. Cytopia has retained<br />
co-promotion rights for Australia and New<br />
Zealand.<br />
Genelabs 2006 Drug discovery Agreement for the development and<br />
commercialization of compounds from<br />
Genelabs’ HCV non-nucleoside drug<br />
discovery program. Genelabs will receive<br />
$20m over a planned two-year research<br />
program. Additional payments could<br />
exceed $175m. In 2008, Genelabs<br />
reported that the partnership was<br />
continuing to the next phase.<br />
© 2009 <strong>IMS</strong> Health In cor po rated or its af fil i ates Page 132