IMS Company Profiles - Report Buyer
IMS Company Profiles - Report Buyer IMS Company Profiles - Report Buyer
IMS COM PANY PRO FILES NOVARTIS Company/Organization Date Area of Collaboration Ascent Therapeutics 2008 Pepducin drug candidates against a specific G-protein coupled receptor (GPCR) target Evotec 2008 Small molecule therapeutics for central nervous system (CNS) Egalet 2008 Parvulet drug delivery technology Terms of Agreement © 2009 IMS Health In cor po rated or its af fil i ates Page 130 Licensing option agreement through the Novartis Option Fund. AT will develop Pepducin drug candidates against a specific GPCR target. Agreement includes an upfront fee, potential milestone payments (possible $200m), and royalties. AT’s Pepducin technology comprises a short peptide derived from a GPCR intracellular loop tethered to a hydrophobic moiety. The technology is capable of inhibiting or activating multiple signals in GPCR pathways; this is a mechanism for disrupting GPCR signal transduction from inside the cell surface, facilitating the treatment of a wide range of conditions. Research collaboration for an initial three years. Evotec will use its drug discovery platform to advance a drug discovery program against a target nominated by Novartis from discovery into the clinic. The programs will be developed to the preclinical stage by Evotec; Novartis will then be responsible for all clinical development activities, manufacture and commercialization of the compounds. Evotec is eligible for an upfront payment, milestone payments which could total more than $28 m, and royalties. Egalet (Denmark) granted Sandoz (part of Novartis) a worldwide license to Parvulet, an oral drug delivery technology comprising a sealed dispensing spoon containing the relevant drug in a formulation requiring hydration. Sandoz will utilize Parvulet to develop a pediatric formulation of an undisclosed compound. Under the terms of the deal Egalet will receive an upfront payment, a milestone payment and royalties from sales.
IMS COM PANY PRO FILES NOVARTIS Company/Organization Date Area of Collaboration BioWa 2008 POTELLIGENT technology Global Alliance for TB Drug Development Terms of Agreement BioWa signed a deal with Novartis relating to its patented POTELLIGENT technology. Novartis will have access to the POTELLIGENT platform for the R&D, manufacture and commercialization of antibody-dependent cellular cytotoxicity (ADCC) enhanced antibodies for an undisclosed number of targets. Novartis will pay BioWa license fees and development milestone payments. BioWa will receive royalties on any products developed by Novartis. BioWa’s POTELLIGENT technology comprises an FUT8 knockout CHO cell line that enables the production of fucose-deficient monoclonal antibodies. 2008 TB The Novartis Institute for Tropical Diseases (NITD) and the Global Alliance for TB Drug Development are collaborating on a 5-year program to develop agents for the treatment of tuberculosis (TB), including drug-resistant TB. The NITD and the Global Alliance for TB Drug Development will share information on new and ongoing TB drug discovery projects. The deal allows for future collaborative development of antibiotic compounds. Discovery stage research is under way. The NITD is a private-public partnership between Novartis and the Singapore Economic Development Board. MorphoSys 2007 Drug discovery and development © 2009 IMS Health In cor po rated or its af fil i ates Page 131 10-year comprehensive strategic alliance to discover and develop therapeutic antibodies against a wide range of diseases, using MorphoSys’ HuCAL-based drug discovery platform. The two companies will combine their R&D capabilities to establish a pipeline of biopharmaceuticals and will share rights to co-developed products in specific territories.
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<strong>IMS</strong> COM PANY PRO FILES NOVARTIS<br />
<strong>Company</strong>/Organization Date Area of<br />
Collaboration<br />
BioWa 2008 POTELLIGENT<br />
technology<br />
Global Alliance for TB<br />
Drug Development<br />
Terms of Agreement<br />
BioWa signed a deal with Novartis relating<br />
to its patented POTELLIGENT technology.<br />
Novartis will have access to the<br />
POTELLIGENT platform for the R&D,<br />
manufacture and commercialization of<br />
antibody-dependent cellular cytotoxicity<br />
(ADCC) enhanced antibodies for an<br />
undisclosed number of targets. Novartis<br />
will pay BioWa license fees and<br />
development milestone payments. BioWa<br />
will receive royalties on any products<br />
developed by Novartis. BioWa’s<br />
POTELLIGENT technology comprises an<br />
FUT8 knockout CHO cell line that enables<br />
the production of fucose-deficient<br />
monoclonal antibodies.<br />
2008 TB The Novartis Institute for Tropical Diseases<br />
(NITD) and the Global Alliance for TB Drug<br />
Development are collaborating on a 5-year<br />
program to develop agents for the<br />
treatment of tuberculosis (TB), including<br />
drug-resistant TB. The NITD and the<br />
Global Alliance for TB Drug Development<br />
will share information on new and ongoing<br />
TB drug discovery projects. The deal<br />
allows for future collaborative<br />
development of antibiotic compounds.<br />
Discovery stage research is under way.<br />
The NITD is a private-public partnership<br />
between Novartis and the Singapore<br />
Economic Development Board.<br />
MorphoSys 2007 Drug discovery and<br />
development<br />
© 2009 <strong>IMS</strong> Health In cor po rated or its af fil i ates Page 131<br />
10-year comprehensive strategic alliance<br />
to discover and develop therapeutic<br />
antibodies against a wide range of<br />
diseases, using MorphoSys’ HuCAL-based<br />
drug discovery platform. The two<br />
companies will combine their R&D<br />
capabilities to establish a pipeline of<br />
biopharmaceuticals and will share rights to<br />
co-developed products in specific<br />
territories.