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<strong>IMS</strong> COM PANY PRO FILES NOVARTIS<br />
Product Class Date Terms of Agreement<br />
QAX 935 R 2005 QAX 935 is a Toll-like receptor 9 (TLR9) agonist<br />
discovered through a research collaboration between<br />
Idera (formerly Hybridon) and Novartis. It is now being<br />
co-developed by Novartis and Idera. In 2005, Hybridon<br />
and Novartis entered into a deal for the discovery,<br />
optimization, development and commercialization of TLR9<br />
immune modulatory oligonucleotide candidates, based on<br />
Hybridon’s proprietary Immune Modulatory<br />
Oligonucleotide (IMO) technology platform, for the<br />
treatment of asthma and allergy. In March 2007, Idera<br />
and Novartis extended the term of the research phase of<br />
their collaboration by one year. Novartis has in-licensed<br />
the exclusive rights to QAX 935 from Idera.<br />
formoterol + mometasone R 2003 Schering-Plough and Novartis agreed to co-develop MFF<br />
258, a combination of Schering-Plough’s corticosteroid<br />
mometasone and the Novartis beta2 agonist formoterol.<br />
gimatecan L 2003 Gained exclusive rights worldwide and semi-exclusive<br />
rights in Italy to Sigma-Tau’s oral topoisomerase I<br />
inhibitor.<br />
fingolimod (FTY 720) L 1997 Exclusive worldwide rights outside Japan licensed-in from<br />
Yoshitomi (now Mitsubishi Tanabe Pharma).<br />
General Research Collaborations<br />
<strong>Company</strong>/Organization Date Area of<br />
Collaboration<br />
Terms of Agreement<br />
FORMA 2009 Inhibitors in oncology Option and license agreement, through<br />
the Novartis Option Fund. FORMA will use<br />
its biology- and chemistry-based platform<br />
to develop inhibitors of an undisclosed<br />
protein-protein interaction cancer target.<br />
FORMA will receive an upfront fee, and is<br />
entitled to potential milestone payments of<br />
over $200 m in total and royalties. Further<br />
terms of the agreement were not<br />
disclosed.<br />
© 2009 <strong>IMS</strong> Health In cor po rated or its af fil i ates Page 129