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IMS Company Profiles - Report Buyer

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<strong>IMS</strong> COM PANY PRO FILES NOVARTIS<br />

Product Class Date Terms of Agreement<br />

QAX 935 R 2005 QAX 935 is a Toll-like receptor 9 (TLR9) agonist<br />

discovered through a research collaboration between<br />

Idera (formerly Hybridon) and Novartis. It is now being<br />

co-developed by Novartis and Idera. In 2005, Hybridon<br />

and Novartis entered into a deal for the discovery,<br />

optimization, development and commercialization of TLR9<br />

immune modulatory oligonucleotide candidates, based on<br />

Hybridon’s proprietary Immune Modulatory<br />

Oligonucleotide (IMO) technology platform, for the<br />

treatment of asthma and allergy. In March 2007, Idera<br />

and Novartis extended the term of the research phase of<br />

their collaboration by one year. Novartis has in-licensed<br />

the exclusive rights to QAX 935 from Idera.<br />

formoterol + mometasone R 2003 Schering-Plough and Novartis agreed to co-develop MFF<br />

258, a combination of Schering-Plough’s corticosteroid<br />

mometasone and the Novartis beta2 agonist formoterol.<br />

gimatecan L 2003 Gained exclusive rights worldwide and semi-exclusive<br />

rights in Italy to Sigma-Tau’s oral topoisomerase I<br />

inhibitor.<br />

fingolimod (FTY 720) L 1997 Exclusive worldwide rights outside Japan licensed-in from<br />

Yoshitomi (now Mitsubishi Tanabe Pharma).<br />

General Research Collaborations<br />

<strong>Company</strong>/Organization Date Area of<br />

Collaboration<br />

Terms of Agreement<br />

FORMA 2009 Inhibitors in oncology Option and license agreement, through<br />

the Novartis Option Fund. FORMA will use<br />

its biology- and chemistry-based platform<br />

to develop inhibitors of an undisclosed<br />

protein-protein interaction cancer target.<br />

FORMA will receive an upfront fee, and is<br />

entitled to potential milestone payments of<br />

over $200 m in total and royalties. Further<br />

terms of the agreement were not<br />

disclosed.<br />

© 2009 <strong>IMS</strong> Health In cor po rated or its af fil i ates Page 129

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