2011 - Europe Direct Iasi
2011 - Europe Direct Iasi
2011 - Europe Direct Iasi
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EUROINVENT <strong>2011</strong><br />
4.17.<br />
Correlatives and complementary experimental models<br />
Title<br />
for the development of antiageing dermatocosmetic<br />
product<br />
Authors Laura Olariu Brandusa Dumitriu<br />
Institution SC Biotehnos SA<br />
Patent no. pending<br />
Description<br />
Despite the exponential develop of cosmetics with<br />
pharmaceutical activity, appropriates methods to quantify the<br />
effects are not yet established.<br />
The anti-ageing claim is a widespread effect for many skin care<br />
products, but usually a few test were done to scientific prove this<br />
action. We assist to an aggressive publicity which sometimes is<br />
not based on relevant investigations concerning the ingredients<br />
toxicity /efficacy profile, the cosmetic legislation being still<br />
permissive from this point of view. We design an assembly of<br />
instrumental methods, comparative and correlative, oriented to<br />
prove the ANTIAGEING effect and the specific target action of<br />
an ingredient: fibroblasts proliferative status, intracellular<br />
Calcium mobilization, molecular basis for changes in collagen<br />
homeostasis (TGF-beta modulation), cellular oxidative stress.<br />
We create an algorithm of dermatocosmetic testing procedure<br />
starting with cellular investigative techniques, representative for<br />
skin disorders and having an end point at the final products<br />
formulation based on cellular changes induced by<br />
phytocompounds.<br />
Therefore, as an application, we define on molecular basis the<br />
therapeutic target of three compounds isolated from indigene<br />
medicinal plant: one could be an effective agent for wound<br />
healing (matrix remodeling action, controlling fibrosis), the<br />
others two acting as catalysts of structural proteins synthesis,<br />
important in chronological ageing.<br />
The implementation of a skin functional parameters scanning in<br />
respect of the active ingredients action will have a deep impact<br />
in the quality of final product formulation, a better treatment<br />
scheme for dermatological dysfunctions and rising<br />
performances for the new skin care anti-ageing ingredients –<br />
one of the main targets of “POS CCE ID 383 SMIS CSNR 6009<br />
CTR 107/2010” project<br />
Class 4<br />
72