Apidra (insulin glulisine) - Sanofi Canada
Apidra (insulin glulisine) - Sanofi Canada
Apidra (insulin glulisine) - Sanofi Canada
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Hyperglycemia:<br />
The use of too low <strong>insulin</strong> dosages or discontinuation of treatment, especially in Type 1 diabetes,<br />
may lead to hyperglycemia and diabetic ketoacidosis. Uncorrected hyperglycemic reactions can<br />
cause loss of consciousness, coma, or death.<br />
Immune<br />
Injection Site and Local Allergic Reactions:<br />
As with any <strong>insulin</strong> therapy, lipodystrophy may occur at the injection site and delay <strong>insulin</strong><br />
absorption. Other injection site reactions with <strong>insulin</strong> therapy include redness, pain, itching at the<br />
injection site, hives, swelling, and inflammation. Continuous rotation of the injection site within<br />
a given area may help to reduce or prevent these reactions. Most minor reactions to <strong>insulin</strong>s<br />
usually resolve in a few days to a few weeks. They may occur if the injection is not properly<br />
made (irritants in the skin cleansing agent or poor injection technique), or if the patient is allergic<br />
to the <strong>insulin</strong> or any excipients.<br />
Rarely, SC administration of <strong>insulin</strong> products can result in lipoatrophy (depression in the skin) or<br />
lipohypertrophy (enlargement or thickening of tissue). Patients should be advised to consult their<br />
doctor if they notice any of these conditions.<br />
Systemic allergic reactions:<br />
Immediate-type allergic reactions are rare. Such reactions to <strong>insulin</strong> (including <strong>insulin</strong> <strong>glulisine</strong>)<br />
or the excipients may, for example, be associated with generalized skin reactions, angioedema,<br />
bronchospasm, hypotension, anaphylactic reaction or shock and may be life threatening (see<br />
CONTRAINDICATIONS and ADVERSE REACTIONS).<br />
Patients who have demonstrated an allergic reaction to other <strong>insulin</strong> products may demonstrate<br />
an allergic reaction to APIDRA.<br />
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