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Forward The Istituto Pasteur-Fondazione Cenci Bolognetti is a private non-profit foundation which was established according to the terms of the bequest of Princess Beatrice Fiorenza Cenci Bolognetti to Sapienza-University of Rome for the general purpose of encouraging scientific research in the area of pasteurian sciences and specifically for founding a Pasteur Institute in Rome. Since 1970 the Institute has been part of a global network of Pasteur Institutes known as Réseau International des Instituts Pasteur et Instituts Associés. The research activity of the Istituto Pasteur-Fondazione Cenci Bolognetti is committed to studying the mechanisms that regulate the basic processes of life. This mission is pursued through the funding of research projects, the award of fellowships and the organization of scientific meetings and seminars. At a time when attention of granting agencies and science policy makers in Italy and Europe is largely focused towards application, it should not be forgotten that important breakthroughs in biology and medicine often originated form curiosity driven research. Starting from this premise, the Istituto Pasteur-Fondazione Cenci Bolognetti has concentrated on the selection of applications exclusively on scientific merit, without bias for application. Our scientific programmes reflect this philosophy. The research projects illustrated in this Report of activity were selected by a peer review system based on highly qualified international referees, to whom we are very grateful. The general themes witness a modern interpretation of the sciences pasteuriennes, with adherence to the mission of the Foundation. Training young researchers has always been a top priority of the Foundation, which is achieved by: i) providing fellowships to work abroad as well as at the Sapienza-University of Rome, ii) cofunding the international Ph.D. Course in Scienze Pasteuriane at the Sapienza and iii) from 2009 starting a program of start-up grants for young brilliant researchers. The institute’s development plan has scheduled the construction of its own laboratories for the near future. These facilities will host leading researchers of all nationalities operating in the field of pasteurian sciences, with special reference to the molecular bases of human pathologies. The results obtained during the years 2007 and 2008, documented in this volume, witness the enthusiasm and productivity of the scientists involved. Paolo Amati President VII REPORT OF ACTIVITY 2007-2008 Ernesto Di Mauro Scientific Director
REPORT OF ACTIVITY 2007-2008 Boards and Staff Administrative Board The Board of Administration is presided over by a President appointed by the Rector of Sapienza-University of Rome chosen from a list of three names selected during a joint session of the board and the Scientific Council. Members of the board include a Scientific Director, four members of the Faculties of Medicine I and II, Natural Sciences, and Pharmacy. Other members are a legal expert designated by the University of Rome Board of Administration, three auditors nominated by the University, the Ministry of the Treasury, and the Ministry of Universities and Scientific Research. President Paolo Amati (Medicine II) Members Mario Coluzzi (Medicine I), Paolo Costantino (Natural Sciences), Raffaele D'Amelio (Medicine II), Ernesto Di Mauro (Natural Sciences), Romano Silvestri (Pharmacy) Secretary Emanuela Gloriani Administrative Expert Daniela Cavallo Auditors Carlo Messina, Simona Ranalli, Valeria Valerio VIII Scientific Council The Scientific Council is a board of seven scholars in the field of the pasteurian sciences. Members are elected to a fouryear term by the Faculties of Medicine I and II, Natural Sciences, and Pharmacy. The scientific director, appointed by the Scientific Council, is ex-officio a member of the Board of Administration. The Scientific Council attends to examine and co-ordinate the research programs as well as the several scientific activities. Scientific Director Ernesto Di Mauro (Natural Sciences) Members Laura Frontali (Natural Sciences), Anna Teresa Palamara (Pharmacy), Angela Santoni (Medicine I), Anna Tramontano (Medicine I), Marco Tripodi (Medicine II), Carlo Turano (Pharmacy) Secretariat Teresa Ariaudo † , Sarah Gainsforth, Maria Pia Lorenzoni, Lynda Romani, Nicoletta Silvestri, Lucia Ugo Consultants Tommaso De Dominicis (legal affairs); Anna Maria Pivetti (architectural supervision); Barbara Hell (financial affairs) † deceased on February 17 th , 2008
Page 1 and 2: Istituto Pasteur Fondazione Cenci B
Page 3 and 4: Contents Forward by Paolo Amati, P
Page 5: Research area 6: New antimicrobial
Page 9 and 10: REPORT OF ACTIVITY 2007-2008 Dario
Page 11 and 12: REPORT OF ACTIVITY 2007-2008 Meetin
Page 13: AREA1 Molecular biology of microorg
Page 16 and 17: P. Amati - Role of the early phases
Page 18 and 19: A. Boffi - Escherichia coli strains
Page 20 and 21: D. De Biase - The glutamate-based a
Page 22 and 23: A. Faggioni - Control of latency an
Page 24 and 25: Paola Londei - Translational regula
Page 27 and 28: A structural biology study of schis
Page 29 and 30: P a r t i c i p a n t s : Luigi Lem
Page 31 and 32: P a r t i c i p a n t s : Gianni Pr
Page 33 and 34: P a r t i c i p a n t s : Lucia Nen
Page 35 and 36: P a r t i c i p a n t s : Alessandr
Page 37 and 38: P a r t i c i p a n t s : Maurizio
Page 39: AREA3 Molecular genetics of eukaryo
Page 42 and 43: F. Ascenzioni - Development and ana
Page 44 and 45: P. Ballario - Molecular machines an
Page 46 and 47: I. Bozzoni - RNA-RNA and RNA-protei
Page 48 and 49: P. Caiafa - Crosstalk between poly(
Page 50 and 51: G. Camilloni - DNA topoisomerases a
Page 52 and 53: P. Costantino - The role of the DAG
Page 54 and 55: M. d’Erme - Epigenetic modificati
Page 56 and 57:
P. Dimitri - Drosophila melanogaste
Page 58 and 59:
L. Fabiani - DNA replication mechan
Page 60 and 61:
C. Falcone - New tools in decipheri
Page 62 and 63:
L. Frontali - New complex mitochond
Page 64 and 65:
M. Gatti - The role of membrane tra
Page 66 and 67:
A. Giacomello - Biology and physiol
Page 68 and 69:
A. Gulino - Regulation of the Hedge
Page 70 and 71:
M. Levrero - Histone Acetyltransfer
Page 72 and 73:
F. Mangia - Molecular regulation of
Page 74 and 75:
A. Musarò - Study of the molecular
Page 76 and 77:
R. Negri - Role of the presumptive
Page 78 and 79:
S. Pimpinelli - Heterochromatin, ge
Page 80 and 81:
M. Stefanini - Biological character
Page 82 and 83:
M. Tripodi - Molecular mechanisms o
Page 84 and 85:
C. Turano - Roles of ERp57 in DNA r
Page 86 and 87:
G. Zardo - Identification of novel
Page 89 and 90:
P a r t i c i p a n t s : Carlo Tra
Page 91 and 92:
P a r t i c i p a n t s : Giulia De
Page 93 and 94:
P a r t i c i p a n t s : Giovanna
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P a r t i c i p a n t s : Francesco
Page 97 and 98:
P a r t i c i p a n t s : Bruno Bot
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P a r t i c i p a n t s : Sergio Fu
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P a r t i c i p a n t s : Maria Egl
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P a r t i c i p a n t s : Stefano C
Page 105:
AREA5 Cellular and molecular immuno
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V. Barnaba - Innovative strategies
Page 110 and 111:
R. Foà - Potential role of miRNAS
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E. Piccolella - Analysis of the mol
Page 114 and 115:
A. Santoni - Molecular mechanism un
Page 116 and 117:
I. Screpanti - Analysis of the role
Page 118 and 119:
R. Sorrentino - The role of HLA-B27
Page 120 and 121:
L. Tuosto - CD28 co-stimulatory mol
Page 122 and 123:
E. Ziparo - The role of Toll Like R
Page 125 and 126:
Peptide effectors of innate immunit
Page 127 and 128:
P a r t i c i p a n t s : Gustavo P
Page 129 and 130:
P a r t i c i p a n t s : Roberta C
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P a r t i c i p a n t s : Giovanna
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P a r t i c i p a n t s : Livia Di
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P a r t i c i p a n t s : Marino Ar
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AREA7 Biology of malaria and other
Page 140 and 141:
Della Torre - Petrarca - Bionomical
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A. Tramontano - Computational Analy
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Year 2007 Barile L, Chimenti I, Gae
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Puglisi R, Bevilacqua A, Carlomagno
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BIBLIOGRAPHY Conigliaro A, Colletti
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BIBLIOGRAPHY Muscolini M, Cianfrocc
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