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Forward<br />

The <strong>Istituto</strong> <strong>Pasteur</strong>-Fondazione Cenci Bolognetti is a private non-profit foundation which<br />

was established according to the terms of the bequest of Princess Beatrice Fiorenza Cenci<br />

Bolognetti to Sapienza-University of Rome for the general purpose of encouraging scientific<br />

research in the area of pasteurian sciences and specifically for founding a <strong>Pasteur</strong> Institute in<br />

Rome. Since 1970 the Institute has been part of a global network of <strong>Pasteur</strong> Institutes known<br />

as Réseau International des Instituts <strong>Pasteur</strong> et Instituts Associés.<br />

The research activity of the <strong>Istituto</strong> <strong>Pasteur</strong>-Fondazione Cenci Bolognetti is committed to<br />

studying the mechanisms that regulate the basic processes of life. This mission is pursued<br />

through the funding of research projects, the award of fellowships and the organization of scientific<br />

meetings and seminars.<br />

At a time when attention of granting agencies and science policy makers in Italy and Europe is<br />

largely focused towards application, it should not be forgotten that important breakthroughs in<br />

biology and medicine often originated form curiosity driven research. Starting from this premise,<br />

the <strong>Istituto</strong> <strong>Pasteur</strong>-Fondazione Cenci Bolognetti has concentrated on the selection of applications<br />

exclusively on scientific merit, without bias for application. Our scientific programmes<br />

reflect this philosophy. The research projects illustrated in this Report of activity were selected by<br />

a peer review system based on highly qualified international referees, to whom we are very grateful.<br />

The general themes witness a modern interpretation of the sciences pasteuriennes, with adherence<br />

to the mission of the Foundation.<br />

Training young researchers has always been a top priority of the Foundation, which is achieved<br />

by: i) providing fellowships to work abroad as well as at the Sapienza-University of Rome, ii) cofunding<br />

the international Ph.D. Course in Scienze <strong>Pasteur</strong>iane at the Sapienza and iii) from 2009<br />

starting a program of start-up grants for young brilliant researchers.<br />

The institute’s development plan has scheduled the construction of its own laboratories for the<br />

near future. These facilities will host leading researchers of all nationalities operating in the field<br />

of pasteurian sciences, with special reference to the molecular bases of human pathologies.<br />

The results obtained during the years 2007 and 2008, documented in this volume, witness the<br />

enthusiasm and productivity of the scientists involved.<br />

Paolo Amati<br />

President<br />

VII<br />

REPORT OF ACTIVITY 2007-2008<br />

Ernesto Di Mauro<br />

Scientific Director

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