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REPORT OF ACTIVITY 2007-2008 Lucia FABIANI, DNA replication mechanisms and genome stability in Saccharomyces cerevisiae ..................... Claudio FALCONE, New tools in deciphering aging and apoptotic pathways ..................................................... Laura FRONTALI, New complex mitochondrial functions in cell biology ............................................................. Maurizio GATTI, The role of membrane trafficking in Drosophila cytokinesis ................................................... Alessandro GIACOMELLO, Biology and physiology of adult cardiac stem/progenitor cells with a view to optimizing their utility for autologous cell transplantation .............................................................................. Alberto GULINO, Regulation of the Hedgehog signaling in neural cell development and disease ............... Massimo LEVRERO, Histone Acetyltransferase (HAT) autoregulatory loops in the regulation of DNA damage responses ......................................................................................................................................................... Franco MANGIA, Molecular regulation of cell proliferation and apoptosis in early embryo blastomeres and granule neuron precursors of the mouse ...................................................................................................... Antonio MUSARO’, Study of the molecular and cellular mechanisms of sarcopenia: role of mIGF-1 and oxidative stress .............................................................................................................................................................. Rodolfo NEGRI, Role of the presumptive human transcription factor Gas41 and of its S. cerevisiae homologue Yaf9 in chromatin organization and gene expression ................................................................... Sergio PIMPINELLI, Heterochromatin, gene silencing and “RNA interference” in Drosophila ........................ Mario STEFANINI, Biological characterization and in vitro culture of spermatogonial stem cells ................ Marco TRIPODI, Molecular mechanisms of the epithelial to mesenchymal transition in hepatocyte ........... Carlo TURANO, Roles of ERp57 in DNA repair and in the regulation of gene expression ........................... Giuseppe ZARDO, Identification of novel genetic and epigenetic targets in Leukemia by genome wide approaches ...................................................................................................................................................................... Research area 4: Molecular recognition in biomolecules Maurizio BRUNORI, How proteins recognize their biochemical partners: ligand binding and folding pathways of PDZ domains ........................................................................................................................................ Felice CERVONE, Plant innate immunity: cell wall-mediated signalling and recognition in plant defense ...... Ernesto DI MAURO, Spontaneous formation and evolution of informational nucleic polymers .................... Martino Luigi DI SALVO, Synthesis of pyridoxal phosphate in the vitamin B 6 salvage pathway and targeting of the cofactor to apo-enzymes ............................................................................................................. Francesco GASPARRINI, Molecular and enantioselective recognition by receptors and proteins studied in the gas phase, in free solution and at solid-liquid interfaces ............................................................................. Cristina LIMATOLA, Molecular and functional approaches to investigate the physiopathological role of the chemokines and their receptors in the central nervous system ....................................................................... Paola PAGGI, Neuronal response to experimental interruption of the neural circuit: a molecular and structural study in autonomic ganglia in vivo ....................................................................................................... Maria SAVINO, Structural and superstructural features of human telomeric chromatin ................................ Research area 5: Cellular and molecular immunology Vincenzo BARNABA, Innovative strategies eliciting CD8 T cell responses by exploiting proteomic analysis and improving cross-presentation ............................................................................................................ Roberto FOA’, Potential role of miRNAS in IgM-mediated signal transduction in normal and neoplastic B cells .............................................................................................................................................................................. Enza PICCOLELLA, Analysis of the molecular mechanisms regulating FOXP3 gene and protein expression in TCR- and CD28-activated CD4 + CD25 - T cells and their influence on regulatory functions ............. Angela SANTONI, Molecular mechanisms underlying the activation of NK cell regulatory and effector functions ......................................................................................................................................................................... Isabella SCREPANTI, Analysis of the role of preTCR-triggered NF-kB in T cell leukemogenesis: relationship with activated Notch signaling .......................................................................................................... Rosa SORRENTINO, The role of HLA-B27 in autoimmunity: from the genetics to the function ................. Loretta TUOSTO, CD28 co-stimulatory molecule as a key regulator of T lymphocyte differentiation and survival: characterisation of the biochemical pathways and molecules coupling CD28 to NF-κB activation ........................................................................................................................................................................ Elio ZIPARO, The role of Toll Like Receptors in immune responses to infections and in inflammation associated pathologies of the male reproductive system ................................................................................... IV 45 47 49 51 53 55 57 59 61 63 65 67 69 71 73 77 79 81 83 85 87 89 91 95 97 99 101 103 105 107 109
Research area 6: New antimicrobial and antiviral agents REPORT OF ACTIVITY 2007-2008 Donatella BARRA, Peptide effectors of innate immunity ......................................................................................... Nicoletta DESIDERI, New antipicornavirus flavanoids: synthesis, biological evaluation and structureactivity relationship studies ....................................................................................................................................... Roberto DI SANTO, Pyrrolyl diketo hexenoic acid derivatives as novel anti-HIV agents targeted to the ribonuclease H function of the HIV-1 reverse transcriptase enzyme ............................................................ Antonello MAI, Design, synthesis and biological evaluation of small molecule epigenetic modulators: a novel approach for anticancer, antifungal and antiviral chemotherapy .......................................................... Elena MATTIA, Effects of resveratrol on Epstein-Barr Virus latent and lytic phases of infection ............... Romano SILVESTRI, Indole nucleus as a selected pharmacophore for the design of novel highly potent anti-viral agents active against HIV-1 (RT and IN inhibitors) and also capable to inhibit HCV and tumor cell replication .................................................................................................................................................. Research area 7: Biology of malaria and other vector-borne diseases Alessandra DELLA TORRE, Vincenzo PETRARCA, Bionomical, genetical and molecular characterization of populations of the Anopheles gambiae complex of sibling species (Diptera: Culicidae), malaria vector in sub-Saharan Africa ....................................................................................................................................................... Anna TRAMONTANO, Computational Analysis of the gene products of the Plasmodium falciparum genome and their interaction with human proteins ............................................................................................................ Bibliography V 113 115 117 119 121 123 127 129 131
Page 1 and 2: Istituto Pasteur Fondazione Cenci B
Page 3: Contents Forward by Paolo Amati, P
Page 7 and 8: REPORT OF ACTIVITY 2007-2008 Boards
Page 9 and 10: REPORT OF ACTIVITY 2007-2008 Dario
Page 11 and 12: REPORT OF ACTIVITY 2007-2008 Meetin
Page 13: AREA1 Molecular biology of microorg
Page 16 and 17: P. Amati - Role of the early phases
Page 18 and 19: A. Boffi - Escherichia coli strains
Page 20 and 21: D. De Biase - The glutamate-based a
Page 22 and 23: A. Faggioni - Control of latency an
Page 24 and 25: Paola Londei - Translational regula
Page 27 and 28: A structural biology study of schis
Page 29 and 30: P a r t i c i p a n t s : Luigi Lem
Page 31 and 32: P a r t i c i p a n t s : Gianni Pr
Page 33 and 34: P a r t i c i p a n t s : Lucia Nen
Page 35 and 36: P a r t i c i p a n t s : Alessandr
Page 37 and 38: P a r t i c i p a n t s : Maurizio
Page 39: AREA3 Molecular genetics of eukaryo
Page 42 and 43: F. Ascenzioni - Development and ana
Page 44 and 45: P. Ballario - Molecular machines an
Page 46 and 47: I. Bozzoni - RNA-RNA and RNA-protei
Page 48 and 49: P. Caiafa - Crosstalk between poly(
Page 50 and 51: G. Camilloni - DNA topoisomerases a
Page 52 and 53: P. Costantino - The role of the DAG
Page 54 and 55:
M. d’Erme - Epigenetic modificati
Page 56 and 57:
P. Dimitri - Drosophila melanogaste
Page 58 and 59:
L. Fabiani - DNA replication mechan
Page 60 and 61:
C. Falcone - New tools in decipheri
Page 62 and 63:
L. Frontali - New complex mitochond
Page 64 and 65:
M. Gatti - The role of membrane tra
Page 66 and 67:
A. Giacomello - Biology and physiol
Page 68 and 69:
A. Gulino - Regulation of the Hedge
Page 70 and 71:
M. Levrero - Histone Acetyltransfer
Page 72 and 73:
F. Mangia - Molecular regulation of
Page 74 and 75:
A. Musarò - Study of the molecular
Page 76 and 77:
R. Negri - Role of the presumptive
Page 78 and 79:
S. Pimpinelli - Heterochromatin, ge
Page 80 and 81:
M. Stefanini - Biological character
Page 82 and 83:
M. Tripodi - Molecular mechanisms o
Page 84 and 85:
C. Turano - Roles of ERp57 in DNA r
Page 86 and 87:
G. Zardo - Identification of novel
Page 89 and 90:
P a r t i c i p a n t s : Carlo Tra
Page 91 and 92:
P a r t i c i p a n t s : Giulia De
Page 93 and 94:
P a r t i c i p a n t s : Giovanna
Page 95 and 96:
P a r t i c i p a n t s : Francesco
Page 97 and 98:
P a r t i c i p a n t s : Bruno Bot
Page 99 and 100:
P a r t i c i p a n t s : Sergio Fu
Page 101 and 102:
P a r t i c i p a n t s : Maria Egl
Page 103 and 104:
P a r t i c i p a n t s : Stefano C
Page 105:
AREA5 Cellular and molecular immuno
Page 108 and 109:
V. Barnaba - Innovative strategies
Page 110 and 111:
R. Foà - Potential role of miRNAS
Page 112 and 113:
E. Piccolella - Analysis of the mol
Page 114 and 115:
A. Santoni - Molecular mechanism un
Page 116 and 117:
I. Screpanti - Analysis of the role
Page 118 and 119:
R. Sorrentino - The role of HLA-B27
Page 120 and 121:
L. Tuosto - CD28 co-stimulatory mol
Page 122 and 123:
E. Ziparo - The role of Toll Like R
Page 125 and 126:
Peptide effectors of innate immunit
Page 127 and 128:
P a r t i c i p a n t s : Gustavo P
Page 129 and 130:
P a r t i c i p a n t s : Roberta C
Page 131 and 132:
P a r t i c i p a n t s : Giovanna
Page 133 and 134:
P a r t i c i p a n t s : Livia Di
Page 135 and 136:
P a r t i c i p a n t s : Marino Ar
Page 137:
AREA7 Biology of malaria and other
Page 140 and 141:
Della Torre - Petrarca - Bionomical
Page 142 and 143:
A. Tramontano - Computational Analy
Page 145 and 146:
Year 2007 Barile L, Chimenti I, Gae
Page 147 and 148:
Puglisi R, Bevilacqua A, Carlomagno
Page 149 and 150:
BIBLIOGRAPHY Conigliaro A, Colletti
Page 151 and 152:
BIBLIOGRAPHY Muscolini M, Cianfrocc
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