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REPORT OF ACTIVITY 2007-2008
Lucia FABIANI, DNA replication mechanisms and genome stability in Saccharomyces cerevisiae .....................
Claudio FALCONE, New tools in deciphering aging and apoptotic pathways .....................................................
Laura FRONTALI, New complex mitochondrial functions in cell biology .............................................................
Maurizio GATTI, The role of membrane trafficking in Drosophila cytokinesis ...................................................
Alessandro GIACOMELLO, Biology and physiology of adult cardiac stem/progenitor cells with a view to
optimizing their utility for autologous cell transplantation ..............................................................................
Alberto GULINO, Regulation of the Hedgehog signaling in neural cell development and disease ...............
Massimo LEVRERO, Histone Acetyltransferase (HAT) autoregulatory loops in the regulation of DNA
damage responses .........................................................................................................................................................
Franco MANGIA, Molecular regulation of cell proliferation and apoptosis in early embryo blastomeres
and granule neuron precursors of the mouse ......................................................................................................
Antonio MUSARO’, Study of the molecular and cellular mechanisms of sarcopenia: role of mIGF-1 and
oxidative stress ..............................................................................................................................................................
Rodolfo NEGRI, Role of the presumptive human transcription factor Gas41 and of its S. cerevisiae
homologue Yaf9 in chromatin organization and gene expression ...................................................................
Sergio PIMPINELLI, Heterochromatin, gene silencing and “RNA interference” in Drosophila ........................
Mario STEFANINI, Biological characterization and in vitro culture of spermatogonial stem cells ................
Marco TRIPODI, Molecular mechanisms of the epithelial to mesenchymal transition in hepatocyte ...........
Carlo TURANO, Roles of ERp57 in DNA repair and in the regulation of gene expression ...........................
Giuseppe ZARDO, Identification of novel genetic and epigenetic targets in Leukemia by genome wide
approaches ......................................................................................................................................................................
Research area 4: Molecular recognition in biomolecules
Maurizio BRUNORI, How proteins recognize their biochemical partners: ligand binding and folding
pathways of PDZ domains ........................................................................................................................................
Felice CERVONE, Plant innate immunity: cell wall-mediated signalling and recognition in plant defense ......
Ernesto DI MAURO, Spontaneous formation and evolution of informational nucleic polymers ....................
Martino Luigi DI SALVO, Synthesis of pyridoxal phosphate in the vitamin B 6 salvage pathway and
targeting of the cofactor to apo-enzymes .............................................................................................................
Francesco GASPARRINI, Molecular and enantioselective recognition by receptors and proteins studied in
the gas phase, in free solution and at solid-liquid interfaces .............................................................................
Cristina LIMATOLA, Molecular and functional approaches to investigate the physiopathological role of the
chemokines and their receptors in the central nervous system .......................................................................
Paola PAGGI, Neuronal response to experimental interruption of the neural circuit: a molecular and
structural study in autonomic ganglia in vivo .......................................................................................................
Maria SAVINO, Structural and superstructural features of human telomeric chromatin ................................
Research area 5: Cellular and molecular immunology
Vincenzo BARNABA, Innovative strategies eliciting CD8 T cell responses by exploiting proteomic
analysis and improving cross-presentation ............................................................................................................
Roberto FOA’, Potential role of miRNAS in IgM-mediated signal transduction in normal and neoplastic
B cells ..............................................................................................................................................................................
Enza PICCOLELLA, Analysis of the molecular mechanisms regulating FOXP3 gene and protein expression
in TCR- and CD28-activated CD4 + CD25 - T cells and their influence on regulatory functions .............
Angela SANTONI, Molecular mechanisms underlying the activation of NK cell regulatory and effector
functions .........................................................................................................................................................................
Isabella SCREPANTI, Analysis of the role of preTCR-triggered NF-kB in T cell leukemogenesis:
relationship with activated Notch signaling ..........................................................................................................
Rosa SORRENTINO, The role of HLA-B27 in autoimmunity: from the genetics to the function .................
Loretta TUOSTO, CD28 co-stimulatory molecule as a key regulator of T lymphocyte differentiation and
survival: characterisation of the biochemical pathways and molecules coupling CD28 to NF-κB
activation ........................................................................................................................................................................
Elio ZIPARO, The role of Toll Like Receptors in immune responses to infections and in inflammation
associated pathologies of the male reproductive system ...................................................................................
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