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• Dendritic cells and leukocyte recruitment • Tumor immunology I • Leukocyte activation • Panomics • Th17: molecular, cellular and clinical aspects • Effector cells and regulatory molecules in allergy • Innate and adaptive immune interactions • Tumor Immunology II • Regulation of inflammatory response • Autoimmunity and regulation of immune response • Innate Immunity <strong>Istituto</strong> <strong>Pasteur</strong> Science Days The Contribution of Basic Science to Therapeutic Innovation Rome, October 23-24,2008 Scientific Committee: L. Frontali, R. Silvestri, C. Turano • Gene therapy and stem cells Chairs: F. Chimenti, L. Frontali I. Bozzoni, RNA as a new therapeutic target: the case of Duchenne muscular dystrophy A. Giacomello, Adult heart stem cells F. Ascenzioni, Therapeutic artificial chromosomes • New vaccines Chairs: L. Frati, A. Santoni M. Pizza, From the genome to the identification of XIII REPORT OF ACTIVITY 2007-2008 antigens for the development of new vaccines M.L. Bernardini, The vaccine against shigellosis: an ongoing challenge through hope and failure A. Saul, Developing vaccines for neglected diseases Award of the Gaia Luoni Prize 2008 on Genetics of susceptibility to malaria • New antitumoral drugs Chairs: V. Ziparo, C. Turano L. Pinna, Protein kinase CK2 as a potential target in the “Signal Transduction Therapy” R. Silvestri, Compounds that interact with tubulina: drugs today and future prospects R. Di Santo, Terminal transferase as a new therapeutic target against cancer: developing DKHA as specific inhibitors of TDT A. Brancale, The use of molecular modelling in designing new antitumoral agents A. Mai, Small molecules as epigenetic modulators of genic expression • Neurodegenerative diseases: towards therapeutical innovation Chairs: C. Falcone, A. Oliverio P. Puri, Drugs against muscular dystrophy F. Altieri, Neurodegenerative disease and oxidative stress: the involvement of proteindisolfuro-isomerasi L. Frontali, Mitochondrial models T. Rinaldi, Involvement of UPS system in neurodegenerative disease E.M. Valente, Pathogenetic mechanisms in Parkinsons disease: mitochondrions and more
AREA1 Molecular biology of microorganisms and viruses
Page 1 and 2: Istituto Pasteur Fondazione Cenci B
Page 3 and 4: Contents Forward by Paolo Amati, P
Page 5 and 6: Research area 6: New antimicrobial
Page 7 and 8: REPORT OF ACTIVITY 2007-2008 Boards
Page 9 and 10: REPORT OF ACTIVITY 2007-2008 Dario
Page 11: REPORT OF ACTIVITY 2007-2008 Meetin
Page 16 and 17: P. Amati - Role of the early phases
Page 18 and 19: A. Boffi - Escherichia coli strains
Page 20 and 21: D. De Biase - The glutamate-based a
Page 22 and 23: A. Faggioni - Control of latency an
Page 24 and 25: Paola Londei - Translational regula
Page 27 and 28: A structural biology study of schis
Page 29 and 30: P a r t i c i p a n t s : Luigi Lem
Page 31 and 32: P a r t i c i p a n t s : Gianni Pr
Page 33 and 34: P a r t i c i p a n t s : Lucia Nen
Page 35 and 36: P a r t i c i p a n t s : Alessandr
Page 37 and 38: P a r t i c i p a n t s : Maurizio
Page 39: AREA3 Molecular genetics of eukaryo
Page 42 and 43: F. Ascenzioni - Development and ana
Page 44 and 45: P. Ballario - Molecular machines an
Page 46 and 47: I. Bozzoni - RNA-RNA and RNA-protei
Page 48 and 49: P. Caiafa - Crosstalk between poly(
Page 50 and 51: G. Camilloni - DNA topoisomerases a
Page 52 and 53: P. Costantino - The role of the DAG
Page 54 and 55: M. d’Erme - Epigenetic modificati
Page 56 and 57: P. Dimitri - Drosophila melanogaste
Page 58 and 59: L. Fabiani - DNA replication mechan
Page 60 and 61: C. Falcone - New tools in decipheri
Page 62 and 63:
L. Frontali - New complex mitochond
Page 64 and 65:
M. Gatti - The role of membrane tra
Page 66 and 67:
A. Giacomello - Biology and physiol
Page 68 and 69:
A. Gulino - Regulation of the Hedge
Page 70 and 71:
M. Levrero - Histone Acetyltransfer
Page 72 and 73:
F. Mangia - Molecular regulation of
Page 74 and 75:
A. Musarò - Study of the molecular
Page 76 and 77:
R. Negri - Role of the presumptive
Page 78 and 79:
S. Pimpinelli - Heterochromatin, ge
Page 80 and 81:
M. Stefanini - Biological character
Page 82 and 83:
M. Tripodi - Molecular mechanisms o
Page 84 and 85:
C. Turano - Roles of ERp57 in DNA r
Page 86 and 87:
G. Zardo - Identification of novel
Page 89 and 90:
P a r t i c i p a n t s : Carlo Tra
Page 91 and 92:
P a r t i c i p a n t s : Giulia De
Page 93 and 94:
P a r t i c i p a n t s : Giovanna
Page 95 and 96:
P a r t i c i p a n t s : Francesco
Page 97 and 98:
P a r t i c i p a n t s : Bruno Bot
Page 99 and 100:
P a r t i c i p a n t s : Sergio Fu
Page 101 and 102:
P a r t i c i p a n t s : Maria Egl
Page 103 and 104:
P a r t i c i p a n t s : Stefano C
Page 105:
AREA5 Cellular and molecular immuno
Page 108 and 109:
V. Barnaba - Innovative strategies
Page 110 and 111:
R. Foà - Potential role of miRNAS
Page 112 and 113:
E. Piccolella - Analysis of the mol
Page 114 and 115:
A. Santoni - Molecular mechanism un
Page 116 and 117:
I. Screpanti - Analysis of the role
Page 118 and 119:
R. Sorrentino - The role of HLA-B27
Page 120 and 121:
L. Tuosto - CD28 co-stimulatory mol
Page 122 and 123:
E. Ziparo - The role of Toll Like R
Page 125 and 126:
Peptide effectors of innate immunit
Page 127 and 128:
P a r t i c i p a n t s : Gustavo P
Page 129 and 130:
P a r t i c i p a n t s : Roberta C
Page 131 and 132:
P a r t i c i p a n t s : Giovanna
Page 133 and 134:
P a r t i c i p a n t s : Livia Di
Page 135 and 136:
P a r t i c i p a n t s : Marino Ar
Page 137:
AREA7 Biology of malaria and other
Page 140 and 141:
Della Torre - Petrarca - Bionomical
Page 142 and 143:
A. Tramontano - Computational Analy
Page 145 and 146:
Year 2007 Barile L, Chimenti I, Gae
Page 147 and 148:
Puglisi R, Bevilacqua A, Carlomagno
Page 149 and 150:
BIBLIOGRAPHY Conigliaro A, Colletti
Page 151 and 152:
BIBLIOGRAPHY Muscolini M, Cianfrocc
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