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Seminars by outstanding invited speakers 2007 May 8 • DNA methylation and genome defense in Neurospora crassa Prof. Eric U. SELKER, Institute of Molecular Biology, University of Oregon, Eugene, USA July 3 • Bordetella pertussis/adenylate cyclase: a Trojan horse for antigen delivery Prof. Agnes Ullmann, Institut Pasteur, Paris, France July 19 • Ultrafast protein folding Prof. William A. EATON, Laboratory of Chemical Physics, National Institutes of Health, Bethesda, USA November 14 • New genome sequences in the genus Drosophila Prof. Thomas C. KAUFMAN, Department of Biology, Indiana University, Bloomington, USA 2008 March 17 • The functions of antibiotics in nature Prof. Julian DAVIES, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada May 26 • SHIP and immune dysfunction: multiple mechanisms Prof. William G. KERR, H. Lee Moffitt Comprehensive Cancer Center and Research Institute, Tampa, USA June 13 • Regulation of gene expression by the activity of the Shigella flexneri type III secretion apparatus Prof. Claude PARSOT, Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France XI REPORT OF ACTIVITY 2007-2008 June 27 • Leucyl-tRNA synthetase quality control mechanisms for protein synthesis June 30 • Evolutionary adaptation of aminoacyl-tRNA synthetases for non-canonical RNA splicing activities in the cell Prof. Susan A. MARTINIS, Department of Biochemistry, University of Illinois, Roger Adams Laboratory Urbana, USA July 1 • 1) Single-molecule biology: principles; 2) Singlemolecule biology: applications to the study of transcription Prof. Jordanka ZLATANOVA, Department of Molecular Biology, University of Wyoming, USA October 17 • Heme protein induced oxidative stress Prof. Michael T. WILSON, Department of Biological Sciences, University of Essex, Colchester, UK November 13 • Protein folding triggered by electron transfer November 15 • Pathways for internal electron transfer in proteins Prof. Harry B. GRAY, California Institute of Technology, Pasadena, USA Novembre 19 • The genomic code for nucleosome positioning Novembre 20 • A code beyond genetics in DNA Prof. Jonathan WIDOM, Department of Chemistry, Northwestern University, Evanston, USA December 18 • Cross-talk between CTCF and PARP in Epstein-Barr Virus Dr. Italo TEMPERA, Wistar Institute, University of Philadelphia, USA
REPORT OF ACTIVITY 2007-2008 Meetings and Conferences organized or supported by the Foundation International Meeting The World of Small Non-Coding RNAs: from Basic to Applied Science Rome, June 11-12, 2007 • Biogenesis and function of small non-coding RNAs • RNAi and therapy • Small non-coding RNA families in plants • miRNA and target identification • Regulatory role of miRNA in cell proliferation/differentiation • miRNAs and therapy Third Joint Workshop History of Medical Entomology Rome, October 11-12, 2007 National Conference Dall’Origine della Terra alla Comparsa della Vita Rome, March 6, 2008 Lincei - Sapienza International Meeting Stem Cells in Tissue Homeostasis, Repair and Cell Therapy Rome, May 28-30, 2008 • The evolution of regenerative mechanisms • Stem cell biology • The tissue niche as an entity of action for stem-cell • From bench-to-bedside research Institut Pasteur - Department of Developmental Biology Meeting Departmental Retreat Rome, June 9-11, 2008 • Mouse Molecular Genetics - CNRS: URA 2578 • Epigenetic Regulation - CNRS: URA 2578 • Macrophages & Development of Immunity - CNRS: URA 2578 XII • Molecular Biology of Development - CNRS: URA 2578 • Mouse Genetics Engineering Center • Mouse Functional Genetics - CNRS: URA 2578 • Molecular Genetics of Development - CNRS: URA 2578 • Stem Cells and Devel opment - CNRS: URA 2578 • Morphogenesis Molecular Genetics - CNRS: URA 2578 • Developmental Genetics of Drosophila - CNRS: URA 2578 • Drosophila Genetics and Epigenetics - CNRS: URA 2578 • Human Developmental Genetics • Gene Expression, Development and Disease - CNRS: URA 2578 Philip Avner with participants from Istituto Pasteur: Framework for our future collaborations General Discussion and Summing up: closing remarks by P. Avner Istituto Pasteur Cultural Day Le Tre Dimensioni della Genomica: Molecole, Geni e Genomi Rome, June 13, 2008 A. Lazcano Araujo, Life without genes? Prebiotic evolution and the emergence of genetic material G. Bernardi, La selezione naturale nell’evoluzione del Genoma A. Tramontano, Dai genomi alle proteine e ritorno 6th National Conference SIICA Rome, June 11-14, 2008 • Novel mechanisms in antigen presentation • BD Biosciences • Immunotherapy of cancer: translation of knowledge, Istituto Superiore di Sanità, Alleanza Contro il Cancro • Dermatologia e reumatologia
Page 1 and 2: Istituto Pasteur Fondazione Cenci B
Page 3 and 4: Contents Forward by Paolo Amati, P
Page 5 and 6: Research area 6: New antimicrobial
Page 7 and 8: REPORT OF ACTIVITY 2007-2008 Boards
Page 9: REPORT OF ACTIVITY 2007-2008 Dario
Page 13: AREA1 Molecular biology of microorg
Page 16 and 17: P. Amati - Role of the early phases
Page 18 and 19: A. Boffi - Escherichia coli strains
Page 20 and 21: D. De Biase - The glutamate-based a
Page 22 and 23: A. Faggioni - Control of latency an
Page 24 and 25: Paola Londei - Translational regula
Page 27 and 28: A structural biology study of schis
Page 29 and 30: P a r t i c i p a n t s : Luigi Lem
Page 31 and 32: P a r t i c i p a n t s : Gianni Pr
Page 33 and 34: P a r t i c i p a n t s : Lucia Nen
Page 35 and 36: P a r t i c i p a n t s : Alessandr
Page 37 and 38: P a r t i c i p a n t s : Maurizio
Page 39: AREA3 Molecular genetics of eukaryo
Page 42 and 43: F. Ascenzioni - Development and ana
Page 44 and 45: P. Ballario - Molecular machines an
Page 46 and 47: I. Bozzoni - RNA-RNA and RNA-protei
Page 48 and 49: P. Caiafa - Crosstalk between poly(
Page 50 and 51: G. Camilloni - DNA topoisomerases a
Page 52 and 53: P. Costantino - The role of the DAG
Page 54 and 55: M. d’Erme - Epigenetic modificati
Page 56 and 57: P. Dimitri - Drosophila melanogaste
Page 58 and 59: L. Fabiani - DNA replication mechan
Page 60 and 61:
C. Falcone - New tools in decipheri
Page 62 and 63:
L. Frontali - New complex mitochond
Page 64 and 65:
M. Gatti - The role of membrane tra
Page 66 and 67:
A. Giacomello - Biology and physiol
Page 68 and 69:
A. Gulino - Regulation of the Hedge
Page 70 and 71:
M. Levrero - Histone Acetyltransfer
Page 72 and 73:
F. Mangia - Molecular regulation of
Page 74 and 75:
A. Musarò - Study of the molecular
Page 76 and 77:
R. Negri - Role of the presumptive
Page 78 and 79:
S. Pimpinelli - Heterochromatin, ge
Page 80 and 81:
M. Stefanini - Biological character
Page 82 and 83:
M. Tripodi - Molecular mechanisms o
Page 84 and 85:
C. Turano - Roles of ERp57 in DNA r
Page 86 and 87:
G. Zardo - Identification of novel
Page 89 and 90:
P a r t i c i p a n t s : Carlo Tra
Page 91 and 92:
P a r t i c i p a n t s : Giulia De
Page 93 and 94:
P a r t i c i p a n t s : Giovanna
Page 95 and 96:
P a r t i c i p a n t s : Francesco
Page 97 and 98:
P a r t i c i p a n t s : Bruno Bot
Page 99 and 100:
P a r t i c i p a n t s : Sergio Fu
Page 101 and 102:
P a r t i c i p a n t s : Maria Egl
Page 103 and 104:
P a r t i c i p a n t s : Stefano C
Page 105:
AREA5 Cellular and molecular immuno
Page 108 and 109:
V. Barnaba - Innovative strategies
Page 110 and 111:
R. Foà - Potential role of miRNAS
Page 112 and 113:
E. Piccolella - Analysis of the mol
Page 114 and 115:
A. Santoni - Molecular mechanism un
Page 116 and 117:
I. Screpanti - Analysis of the role
Page 118 and 119:
R. Sorrentino - The role of HLA-B27
Page 120 and 121:
L. Tuosto - CD28 co-stimulatory mol
Page 122 and 123:
E. Ziparo - The role of Toll Like R
Page 125 and 126:
Peptide effectors of innate immunit
Page 127 and 128:
P a r t i c i p a n t s : Gustavo P
Page 129 and 130:
P a r t i c i p a n t s : Roberta C
Page 131 and 132:
P a r t i c i p a n t s : Giovanna
Page 133 and 134:
P a r t i c i p a n t s : Livia Di
Page 135 and 136:
P a r t i c i p a n t s : Marino Ar
Page 137:
AREA7 Biology of malaria and other
Page 140 and 141:
Della Torre - Petrarca - Bionomical
Page 142 and 143:
A. Tramontano - Computational Analy
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Year 2007 Barile L, Chimenti I, Gae
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Puglisi R, Bevilacqua A, Carlomagno
Page 149 and 150:
BIBLIOGRAPHY Conigliaro A, Colletti
Page 151 and 152:
BIBLIOGRAPHY Muscolini M, Cianfrocc
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