Pocket Program - CROI

CROI 2013 Session 93
456 A Longitudinal Study of the Effects of Aging and HIV-1
Infection on Cognitive Performance
Becky Haynes* 1 , T Karren 1 , S Casey 2 , J Dunn 1 , F Zelaya 1 ,
M Pitkanen 1 , R Kulasegaram 3 , G Barker 1 , and M Kopelman 1
1 Kings Coll London, Inst of Psychiatry, UK;; 2 Acquired Brain Injury
Ireland, Dublin;; and 3 Guys and St Thomas NHS Fndn Trust, London, UK
457 Genome-wide Association Study of Peripheral Neuropathy
Paul Leger* 1 , D Johnson 1 , G Robbins 2 , R Shafer 3 , D Clifford 4 , J Li 1 ,
P McLaren 5,6 , and D Haas 1
1 Vanderbilt Univ Sch of Med, Nashville, TN, US;; 2 Massachusetts Gen
Hosp, Harvard Univ, Boston, US;; 3 Stanford Univ, CA, US;; 4 Washington
Univ Sch of Med, St Louis, MO, US;; 5 Broad Inst of MIT and Harvard,
Cambridge, MA, US;; and 6 Ecole Polytechnique Federale de Lausanne,
Univ of Lausanne, Switzerland
461a Moderate Neurocognitive Decline Can Be Detected over a
Grace Lu* 1 , L Cysique1,2,3,4 , K Siefried4 , B Draper5 , and B Brew1,3,4 1Univ of New South Wales, St Vincents Hosp Clin Sch, Sydney Australia;;
2 3 Neurosci Res Australia, Sydney;; St Vincents Ctr for Applied Med Res,
Sydney, Australia;; 4St Vincents Hosp, Sydney, Australia;; and 5Sch of
Psychiatry, Univ of New South Wales, Sydney Australia
463 Matrix Metalloproteinases and Relation to Brain Status in
Early HV Infection
Ann Ragin* 1 , H Du 2 , Y Gao 1 , S Li 1 , R Mahadevia 1 , C Sammet 1 , Y Wu 2 ,
and L Epstein 1
1 Northwestern Univ, Chicago, IL, US and 2 NorthShore Univ Hlth System,
Evanston, IL, US
464 Effects of HIV Clade B and C on Brain Volumetric
Measurements
Mario Ortega* 1 , J Joska 2 , J Heaps 3 , F Vaida 4 , A Agrawal 1 , R Paul 3 ,
and B Ances 1
1 Washington Univ, St Louis, MO, US;; 2 Univ of Cape Town, South Africa;;
3 Univ of Missouri, St Louis, US;; and 4 Univ of California, San Diego, US
466 Effects of Primary and Chronic HIV Infection on White Matter
Integrity Using Diffusion Tensor Imaging
Patrick Wright* 1 , R Fernandez 2 , D Meyerhoff 3 , R Price 3 ,
K Robertson 4 , E Lee 3 , J Rutlin 1 , J Shimony 1 , S Spudich 5 , and B Ances 1
1 Washington Univ in St Louis, MO, US;; 2 Univ of Puerto Rico, Rio
Piedras;; 3 Univ of California, San Francisco, US;; 4 Univ of North Carolina
at Chapel Hill, US;; and 5 Yale Univ, New Haven, CT, US
467 Effects of HIV and Hepatitis C Co-infection on White Matter
Structural Integrity and White Matter Volumes
Jodi Heaps* 1 , P Wright 2 , B Ances 2 , D Clifford 2 , and R Paul 1
1 Univ of Missouri-St Louis, US and 2 Washington Univ Sch of Med,
St Louis, MO, US
458
with Asymptomatic Neurocognitive Impairment and Minor
A Livelli1,2 , * 1 , L Pia3 , S Carosella1 , M Farenga1 ,
V Ghisetti1 , A Calcagno1,3 , and P Caramello1 1 2 Amedeo of Savoia Hosp, Turin, Italy;; CRT, G Goria Fndn, Turin, Italy;;
and 3Univ of Turin, Italy
459
Jordan Lake* 1 , Q Vo2 , L Jacobson3 , N Sacktor3 , W Post3 , J Becker4 ,
F Palella5 , A Ragin5 , and T Brown3 1 2 Univ of California, Los Angeles, US;; Henry M Jackson Fndn for the
Advancement of Military Med, Bethesda, MD, US;; 3Johns Hopkins Univ,
Baltimore, MD, US;; 4Univ of Pittsburgh, PA, US;; and 5 460
Northwestern
Univ, Chicago, IL, US
Proteinuria Is Associated with Neurocognitive Impairment in
HIV +
Robert Kalayjian* 1 , K Wu2 , S Evans2 , M Pallaki3 , D Clifford4 ,
and M Smurzynski2 1 2 MetroHlth Med Ctr, Cleveland, OH, US;; Harvard Sch of Publ Hlth,
Boston, MA, US;; 3 468 Neuroimaging Correlates of Prior Immunosuppression and
Cognitive Status in HIV
Christine Fennema-Notestine*
Louis Stokes VAMC, Cleveland, OH, US;; and
4Washington Univ, St Louis, MO, US
1 , M Taylor1 , R Notestine1 , T Wolfson2 ,
A Gamst1,2 , S Archibald1 , R Theilmann1 , R Heaton1 , C Marra3 , I Grant1 ,
and CHARTER Group
1 2 Univ of California, San Diego, La Jolla, US;; San Diego Supercomputer
Ctr, La Jolla, CA, US;; and 3Univ of Washington, Seattle, US
469 Diffusion Tensor Imaging Uncovers Specific Brain
Microstructural Deficits during Chronic HIV-1 Infection of
Humanized Mice
Prasanta Dash*, J Knibbe, T Gutti, E Makarov, D Baber, S Gorantla,
L Poluektova, H Gendelman, and M Boska
Univ of Nebraska Med Ctr, Omaha, US
c Wednesday, 2:30-4 pm; Hall B2
Session 93–Poster Abstracts
Human Genomics
470 Genome-Wide Association Study of Phenotypic HIV-1
Co-receptor Usage in Treatment-naïve Patients from the
ACTG A5095 Trial
Timothy Henrich* 1,2 , P McLaren1,2,3,4 , S Rao5 , N Lin2,6 , F Giguel6 ,
H Ribaudo2,7 , R Gulick8 , P de Bakker1,2,3 , and D Kuritzkes1,2 1 2
Harvard Med Sch,
Boston, MA, US;; 3Broad Inst of Harvard and MIT, Cambridge, MA,
US;; 4Ecole Polytechnique Federale de Lausanne and Univ of Lausanne,
Switzerland;; 5Harvard Univ, Cambridge, MA, US;; 6Massachusetts Gen
Hosp, Boston, US;; 7Harvard Sch of Publ Hlth, Boston, MA, US;; and
8Weill Med Coll of Cornell Univ, New York, NY, US
461b
H Predicts HIV-1-related Neurocognitive Impairment and
Kumud Singh*, F Vaida, C Fennema-Notestine, R Ellis, S Letendre,
D Franklin Jr, D Rosario, R Heaton, I Grant, and CHARTER Group
Univ of California San Diego, La Jolla, US
c Wednesday, 2:30-4 pm; Hall B2
Session 92–Poster Abstracts
Neuroimaging Studies
462
Weeks in HIV + Individuals Commencing ART
Alan Winston* 1 , R Puls2 , S Kerr2 , C Duncombe3 , P Li4 , J Gill5 ,
R Ramautarsing5 , S Taylor-Robinson1 , S Emery2 , D Cooper2 ,
for ALTAIR Study Group
1 2 3 Imperial Coll London, UK;; The Kirby Inst, Sydney, Australia;; HIVNAT,
Bangkok;; 4Queen Elizabeth Hosp, Hong Kong, China;; and 5 471 Novel HLA Associations with HIV Control in a Previously
Uncharacterized Immunogenetic Context
Humberto Valenzuela-Ponce*, S Avila-Rios, M Soto-Nava,
D Garrido-Rodriguez, T Garcia-Tellez, V Quiroz-Morales,
C Garcia-Morales, R Hernandez-Juan, A Murakami-Ogasawara,
G Reyes-Teran, and Mexican HIV Molecular Epidemiology Project Group
Natl Inst of Respiratory Diseases, Mexico City, Mexico
472
HLA-B*57
C Granier
Calgary Hlth,
Canada
1 , Emilie Battivelli* 1 , A Venet2 , C Lecouroux2 , O Lambotte3 ,
C Delaugerre1 , J-M Molina4 , F Clavel1 , and A Hance1 1 2 INSERM U941, Hosp St Louis, Paris, France;; INSERM U1012, Faculte
de Med Paris-Sud, France;; 3Hosp de Bicetre, le Kremlin-Bicetre, France;;
and 4Hosp St Louis, Paris, France
473 Human MHC Gene Variants and Immune Control of HIV-1
the Immunochip
Heather Prentice* 1 , N Pajewski2 , E Brown1 , S Allen3 , E Hunter3 ,
R Kaslow1 , and J Tang1 1 2 Univ of Alabama at Birmingham, US;; Wake Forest Univ, Winston-
Salem, NC, US;; and 3Emory Univ, Atlanta, GA, US
474 Gene Expression Profiling Identifies Genes with a Mechanistic
+
Individuals on ART
Nadejda Beliakova-Bethell* 1 , S Little1 , P Du2 , S Rought2 ,
D Richman1,2 , and C Woelk1,2 1 2 Univ of California, San Diego, La Jolla, US and VA San Diego, CA, US
475 HLA Associations with Immunological Recovery and Drug
Toxicities in HIV-1 + Adults
Jane O’Halloran* 1 , J Crowley 2 , M Fagan 2 , C Hickey 2 , S Stokes 2 ,
A Kinsella 2 , H Tuite 1 , R Hagan 2 , and C Bergin 1
1 St Jamess Hosp, Dublin, Ireland and 2 Irish Blood Transfusion Svc,
Dublin, Ireland
465
Magnetic Resonance Spectroscopy in Primary HIV Infection
Marie Grill* 1 , J Peterson1 , E Lee1 , R Walter1 , D Fuchs2 , L Hagberg3 ,
D Meyerhoff1 , R Price1 , and S Spudich4 476
Genes Differentially Expressed in HIV
1 2 Univ of California, San Francisco, US;; Innsbruck Med Univ, Austria;;
3 4 Univ of Gothenburg, Sweden;; and Yale Univ, New Haven, CT, US
+ Individuals following
ART
Marta Massanella* 1 , A Singhania2 , N Beliakova-Bethell3 , J Perez-Santiago3 ,
R Pier3 , C White2,3 , J Blanco1 , D Richman2,3 , S Little3 , and C Woelk2,3 1Fndn irsiCaixa-HIVACAT, Inst de Recerca en Ciencies de la Salut
Germans Trias i Pujol, Hosp Germans Trias, Univ Autonoma de
Barcelona, Spain;; 2VA San Diego Hlthcare System, CA, US;; and 3Univ of
California, San Diego, La Jolla, US
Program 37
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