Pocket Program - CROI

CROI 2013 Session 89
413 Risk of Clinically Significant Depression in HIV + Patients:
Effect of ARV Drugs
Felix Gutierrez* 1 , L Garcia 2 , S Padilla 1 , D Alvarez 3 , S Moreno 4 ,
G Navarro 5 , JL Gomez-Sirvent 6 , F Vidal 7 , V Asensi 8 , M Masia 1 ,
and CoRIS
1 Hosp Gen Univ de Elche, Alicante, Spain;; 2 Hosp Univ Sant Joan
dAlacant, Alicante, Spain;; 3 Ctr Natl de Epidemiologia, Inst de Salud
Carlos III, Madrid, Spain;; 4 Hosp Ramon y Cajal, Madrid, Spain;; 5 Hosp
Parc Tauli, Sabadell, Barcelona, Spain;; 6 Hosp Univ de Canarias, Santa
Cruz de Tenerife, Spain;; 7 Hosp Univ Joan XXIII, Tarragona, Spain;; and
8 Hosp Univ Central de Asturias, Oviedo, Spain
c Monday, 2:30-4 pm; Hall B2
Session 87–Poster Abstracts
Central Nervous System Viral Evolution and
Compartmentalization
417 Correlating Neuropathogenesis with Brain Infection Dynamics
in the SIV -infected CD8-depleted Rhesus Macaque Model
Using Bayesian Phylogeography
Samantha Strickland* 1 , N Veras 1 , M Prosperi 1 , T Burdo 2 , D Nolan 1 ,
M Suchard 3 , K Williams 2 , and M Salemi 1
1 Univ of Florida, Gainesville, US;; 2 Boston Coll, Chestnut Hill, MA, US;;
and 3 Univ of California, Los Angeles, US
418 Distinct Regional Compartmentalization in the Central
Nervous System of an R5 SHIV + Rhesus Macaque with
Severe Encephalitis
K Zhuang 1 , Ana Rachel Leda* 1 , C Harbison 2 , H Knight 2 ,
S Westmoreland 2 , and C Cheng-Mayer 1
1 Aaron Diamond AIDS Res Ctr, New York, NY, US and 2 New England
Primate Res Ctr, Harvard Med Sch, Southborough, MA, US
c Tuesday, 2:30-4 pm; Hall B2
Session 88–Poster Abstracts
Neuropathogenesis Mechanisms
419 Proteomic Analysis of Molecular Interactions of the
Macrophage-derived Protease Cathepsin B During HIV-1
Infection in vitro
Yisel Cantres-Rosario* 1 , M Plaud-Valentin 1 , R Quiles 2,3 ,
J Perez-Laspiur 1 , Y Rodriguez 1 , S Shaffer 4 , and L Melendez 1
1 Univ of Puerto Rico Med Sci Campus, San Juan;; 2 Univ of Puerto Rico
Rio Pedras, San Juan;; 3 Interamerican Univ of Puerto Rico, Bayamon;;
and 4 Univ of Massachussets, Boston, US
420 Heme Oxygenase-1 RNA Is Increased in HIV + Brains with
Neurocognitive Disorders and in HIV + Encephalitic Brains
Surendra Ambegaokar* 1 , A Gill 1 , C Kovacsics 1 , S Cross 1 ,
B Gelman 2 , and D Kolson 1
1 Univ of Pennsylvania, Philadelphia, US and 2 Univ of Texas Med Branch,
Galveston, US
424
SAMHD1 during Lentiviral Infection of Astrocytes and
Macrophages
Erin Buchanan*, D Espinoza, A Moyer, J Clements, and K Witwer
Johns Hopkins Univ Sch of Med, Baltimore, MD, US
425
Resultant Neurotoxic Activity via Voltage-gated Potassium
P Xu, Jianuo Liu*, and H Xiong
Univ of Nebraska Med Ctr, Omaha, US
426 Morphologic and Molecular Pathology in the Spinal Cord of
SIV + Macaques
Lisa Mangus*, J Dorsey, and J Mankowski
Johns Hopkins Univ, Baltimore, MD, US
414
Neurocognitive Impairment in an Indian Cohort
Myres Tilghman* 1 , S Deshpande2 , J Bhattacharya2 , M Ghate2 ,
T Marcotte1 , D Smith1,3 , and S Mehendale4 1 2 Univ of California, San Diego, La Jolla, US;; Natl AIDS Res Inst, Pune,
India;; 3VA San Diego Hlthcare System, La Jolla, CA, US;; and 4Natl Inst
of Epidemiology, Chennai, India
415
Sequencing
Tiffany Yuh* 1 , J Chiarella1 , B Reese2 , E St John2 , B Simen2 ,
M Mohiuddin2 , J Peterson3 , R Price3 , M Kozal1 , and S Spudich1 1 2 Yale Univ Sch of Med, New Haven, CT, US;; 454 Life Sci, Branford, CT,
US;; and 3Univ of California, San Francisco, US
416 Clade-specific Differences in HIV-1 Pathogenesis
Santhi Gorantla* 1 , E Makarov1 , S Adem1 , L Wu1 , C Wood2 ,
L Poluektova1 , and H Gendelman1 427 The 7-Nicotinic Acetylcholine Receptor Is Up-regulated in a
Transgenic Mouse Model for HIV
Coral Capo-Velez*
1 2 Univ of Nebraska Med Ctr, Omaha, US and Univ of Nebraska-Lincoln, US
1 , B Morales1 , R Melendez2 , and J Lasalde-Dominicci1 1 2 Univ of Puerto Rico, San Juan and Univ of Puerto Rico, Med Sci, San Juan
428 The Effects of Pediatric SIV Infection on the Integrity of the
Hippocampus
K Bradshaw1 , K Curtis1 , M Rollins1 , S Graham1 , D Jackson1 , M M’Baye1 ,
H Carryl1 , T Heinbockel1 , K Abel2 , and Mark Burke* 1
1 2 Howard Univ, Washington, DC, US and Univ of North Carolina at
Chapel Hill, US
429 Cocaine Potentiates Cathepsin B Secretion in the Plasma of
HIV + Hispanic Women
Frances Zenon*, M Plaud, V Wojna, and L Melendez
Univ of Puerto Rico Sch of Med and NeuroAIDS Prgm, Med Sci Campus
c Tuesday, 2:30-4 pm; Hall B2
Session 89–Poster Abstracts
Central Nervous System Inflammation and
Biomarkers of HIV-associated Neurocognitive
Disorders
Program 35
Poster Listings
430
Initiation of ART in Individuals with Chronic HIV Infection
in Thailand
Bonnie Slike* 1 , V Valcour 2 , S Krebs 1 , P Sithinamsuwan 3 ,
P Saengtawan 4 , A Schuetz 5 , J Kim 1 , N Michael 1 , J Ananworanich 4,6 ,
M Marovich 1 , and SEARCH 011 Study Team
1 US Military HIV Res Prgm, Silver Spring, MD;; 2 Univ of California, San
Francisco, US;; 3 Phramongkutklao Hosp, Bangkok, Thailand;; 4 SEARCH
and Thai Red Cross AIDS Res Ctr, Bangkok;; 5 Armed Forces Res Inst
of Med Sci, Bangkok, Thailand;; and 6 Chulalongkorn Univ, Bangkok,
Thailand
431
HIV-associated Neuro-inflammation
Meera Singh* 1 , D Davidson 1 , S Ramirez 2 , J Silva 1 , and S Maggirwar 1
1 Univ of Rochester Med Ctr, NY, US and 2 Temple Univ Sch of Med,
Philadelphia, PA, US
432
the Spectrum of HIV Disease Progression
Sheila Keating* 1,2 , J Peterson 2 , M Gisslen 3 , J Heitman 1 , S Wu 1 ,
S Spudich 4 , P Norris 1,2 , and R Price 2
1 Blood Systems Res Inst, San Francisco, CA, US;; 2 Univ of California,
San Francisco, US;; 3 Univ of Gothenburg, Sweden;; and 4 Yale Univ, New
Haven, CT, US
433
in HIV-1 + Brain: Implications for HIV-related Aging and
Alzheimer’s Disease
Dong Tran*, N Kumar, C Teodorof, A Adame, B Gouaux, D Moore,
W Dumaop, S Michael, E Masliah, K Singh, and HIV Neurobehavioral
Res Prgm
Univ of California, San Diego, La Jolla, US
421 Suppression of Brain Heme Oxygenase-1 in HIV Infection:
Alexander Gill* 1 , S Cross1 , C Kovacsics1 , B Gelman2 , and D Kolson1 1 2 Univ of Pennsylvania Perelman Sch of Med, Philadelphia, US and Univ
of Texas Med Branch, Galveston, US
422
and Astrocytes
Stephanie Cross* 1 , A Gill1 , C Kovacsics1 , S Ambegaokar1 , P Vance1 ,
L Kolson1 , B Gelman2 , and D Kolson1 434 Modeling the Development of Chronic Neuroinflammation
following Blunting of Primary Viremia through Partial
Vaccine Protection
Debbie Ferguson*
1 2 Univ of Pennsylvania, Philadelphia, US and Univ of Texas Med Branch,
Galveston, US
423 SIV Infection and Interferon- Modulate microRNA Profiles
of Macaque Astrocytes
Diego Espinoza*, E Buchanan, A Moyer, J Clements, and K Witwer
Johns Hopkins Univ Sch of Med, Baltimore, MD, US
1 , S Clarke1 , C Ham1 , A Das2 , B Berkhout2 , A Meiser3 ,
S Patterson3 , N Berry1 , and N Almond1 1 2 Natl Inst for Bio Standards and Control, Potters Bar, UK;; Academic
Med Ctr, Univ of Amsterdam;; and 3Imperial Coll London, UK
435 + HIV DNA Predicts HIV-associated Neurocognitive
Impairment and Regional Brain Atrophy in Treatment-naïve
Victor Valcour* 1 , J Ananworanich2,3,4 , M Agsalda5 , K Kallianpur5 ,
T Chalermchai3 , P Sithinamsuwan6 , S Tipsuk3 , A Schuetz7 , C-Y Liang5 ,
B Shiramizu5 , and SEARCH 007 and 011 Study Groups
1 2 Univ of California, San Francisco, US;; Chulalongkorn Univ, Bangkok,
Thailand;; 3South East Asia Res Collaboration with the Univ of Hawaii,
Bangkok, Thailand;; 4HIVNAT Res Collaboration, Bangkok, Thailand;; 5Univ of Hawaii at Manoa, Honolulu, US;; 6Phramongkutklao Hosp, Bangkok,
Thailand;; and 7US Armed Forces Res Inst of Med Sci, Bangkok, Thailand