Pocket Program - CROI

CROI 2013 Session 75
329 Impact of Acute HIV-1 Infection on Th17/Treg Balance and
T Cell Activation in the Sigmoid Colon
Alexandra Schuetz* 1,2 , Y Phuang-Ngern 1 , R Rerknimitr 3 , I Sereti 4 ,
M Robb 2 , V Ngauy 1,2 , R Dewar 5 , J Kim 2,6 , M De Souza 1,2 ,
J Ananworanich 3,6,7 , and RV254/SEARCH 010 Study Team
1 Armed Forces Res Inst of Med Sci, Bangkok, Thailand;; 2 US Military HIV
Res Prgm, Walter Reed Army Inst of Res, Silver Spring, MD;; 3 Faculty of
Med, Chulalongkorn Univ, Bangkok, Thailand;; 4 NIH, Bethesda, MD, US;;
5 SAIC-Frederick Inc, MD, US;; 6 SEARCH, Bangkok, Thailand;; and 7 The
Thai Red Cross AIDS Res Ctr, Bangkok
330 Paucity of Naïve Th17 Precursors as a Potential Cause for
Memory Th17 Deficiency in HIV + Individuals
Sandrina Da Fonseca* 1 , A Gosselin 1 , R-M Boulassel 2 , J-P Routy 2,3 ,
N Bernard 2 , C Tremblay 1 , and P Ancuta 1
1 Ctr de Res du Ctr Hosp de lUniv de Montreal Saint Luc, Canada;; 2 Royal
Victoria Hosp, McGill Univ Hlth Ctr, Montreal, Canada;; and 3 McGill
Univ, Montreal, Canada
331
Translocation and Immune Activation
Connie Kim* 1 , C Kovacs2 , G Kandel1,3,4 , S Huibner1 , D Chege1 ,
K Shahabi1 , E Benko2 , M Loutfy1,2,5 , M Ostrowski1,3 , and R Kaul1,4 1 2 3 Univ of Toronto, Canada;; Maple Leaf Med Clin, Toronto, Canada;; St
Michaels Hosp, Toronto, Canada;; 4Univ Hlth Network, Toronto, Canada;;
and 5 341 Prolonged Preservation of HIV-specific Cellular Immunity in
Recently HIV
+ Individuals Receiving Maraviroc Intensified
HAART
AI Kawana-Tachikawa* 1,2 , J Llibre3 , I Bravo3 , R Escrig3 , B Mothe1,3 ,
J Miro4 , J Gatell4 , A Iwamoto2 , B Clotet1,3 , and C Brander1 1 2 IrsiCaixa AIDS Res Inst, HIVACAT, Badalona, Spain;; Inst of Med Sci,
Univ of Tokyo, Japan;; 3Fundacio Lluita Contra La Sida, Hosp Univ
Germans Trias i Pujol, Badalona, Spain;; and 4Hosp Clin, IDIBAPS, Univ
of Barcelona, Spain
c Monday, 2:30-4 pm; Hall B2
Session 73–Poster Abstracts
Immune Activation/Function in HIV Infection
332 Circulating Microparticles as Markers of Immune Activation
in Treatment-naïve HIV + Patients
B Smit, Willem Blok*, M Van Schilfgaarde, W Terpstra,
G Van den Berk, A Leyte, and K Brinkman
OLVG Hosp, Amsterdam, The Netherlands
333 The Effect of HIV Infection on Markers of Inflammation among
Men with Known HIV Seroconversion Dates in the Multicenter
AIDS Cohort Study
Heather McKay* 1 , J Bream 1 , J Margolick 1 , O Martinez-Maza 2 , J Phair 3 ,
C Rinaldo 4 , and L Jacobson 1
1 Johns Hopkins Univ Bloomberg Sch of Publ Hlth, Baltimore, MD, US;;
2 Univ of California, Los Angeles, US;; 3 Northwestern Univ, Feinberg Sch of
Med, Chicago, IL, US;; and 4 Univ of Pittsburgh Sch of Publ Hlth, PA, US
334
Seronegative Intravenous Drug Users that Share Needles
Compared to Non-sharing IDU Controls
Costin Tomescu* 1 , P Smith2 , D Metzger2 , and L Montaner1 1 2 The Wistar Inst, Philadelphia, PA, US and Univ of Pennsylvania,
Philadelphia, US
335
Translocation in Primary HIV Infection
M Chevalier1,2 , G Petitjean1 , C Didier1 , C Dunyach-Remy3,4 , P-M Girard5 ,
L Meyer6 , J-P Lavigne3,4 , F Barre-Sinoussi1 , D Scott-Algara1 ,
and Laurence Weiss* 1,7,8
1 2 Inst Pasteur, Paris, France;; Univ Paris Diderot, Sorbonne Paris Cite,
France;; 3INSERM U1047, Univ Montpellier 1, UFR de Medecine, Nimes,
France;; 4Ctr Hosp Univ Caremeau, Nimes, France;; 5Hosp Saint-Antoine,
Paris, France;; 6INSERM U 1018, Univ Paris Sud, France;; 7Univ Paris
Descartes, Sorbonne Paris Cite, France;; and 8 c Monday, 2:30-4 pm; Hall B2
Session 75–Poster Abstracts
Mucosal Factors in HIV Transmission and Infection
344
Cindy Liu*
Hosp Europeen Georges
Pompidou, Paris, France
1,2,3 , B Hungate3 , A Tobian2,4 , D Serwadda5 , R Lester1 ,
G Kigozi5 , R Galiwango5 , M Wawer4 , R Gray4 , and L Price1,6 1 2 Translational Genomics Res Inst, Flagstaff, AZ, US;; Johns Hopkins Univ
Sch of Med, Baltimore, MD, US;; 3Northern Arizona Univ, Flagstaff, US;;
4Johns Hopkins Univ Bloomberg Sch of Publ Hlth, Baltimore, MD, US;;
5 6 Rakai Hlth Sci Prgm, Entebbe, Uganda;; and George Washington Univ
Sch of Publ Hlth, Washington, DC, US
345
and Implications of HIV Transmission
Minh Dinh*, R Veazey, and T Hope
Northwestern Univ, Feinberg Sch of Med, Chicago, IL, US
+ 337
Plasma
Neeru Bhardwaj* and J Coffin
Tufts Univ, Boston, MA, US
c Monday, 2:30-4 pm; Hall B2
Session 74–Poster Abstracts
Immune Activation, T Cell Homeostasis, and Therapy
338 Augmented Interferon Responses and Inflammation
Associated with Altered Tryptophan and Adrenal Steroid
Edana Cassol* 1,2 , V Misra 1 , S Morgello 3 , and D Gabuzda 1,2
1 Dana-Farber Cancer Inst, Boston, MA, US;; 2 Harvard Med Sch, Boston,
MA, US;; and 3 Mt Sinai Med Ctr, New York, NY, US
339
Infection
Jeffrey Ahlers* 1 , R-P Sekaly 1 , M Cameron 1 , K Ghneim 1 , A Filali 1 ,
M Ghannoum 2 , P Mukherjee 2 , C Shive 3 , B Rodriguez 3 , and M Lederman 3
1 Vaccine and Gene Therapy Inst-Florida, Port St Lucie, US;; 2 Ctr for Med
Mycology and OHARA Case Mycology Unit, Cleveland, OH, US;; and
3 Case Western Reserve Univ, Cleveland, OH, US
340 Lower Activation in Periphery and Cervical Tissue
Gene Expression Associates with Highly Exposed HIV-1
Shaheed Abdulhaqq* 1,2 , C Tomescu 1 , V Tamayo 3 , L Azzoni 1 ,
S Garced 3 , L Showe 1 , C Irizarry 3 , C Zorrilla 3 , and L Montaner 1
1 The Wistar Inst, Philadelphia, PA, US;; 2 Univ of Pennsylvania Perelman
Sch of Med, Philadelphia, US;; and 3 Univ of Puerto Rico, Sch of Med,
San Juan
342 Clinical Impact of Altered T Cell Homeostasis in Treated HIV +
P Ndumbi 1 , J Gillis 2 , J Raboud 2,3 , M Loufty 4 , M Klein 5 , N Machouf 6 ,
C Cooper 7 , R Hogg 8,9 , A Burchell 10 , Christos Tsoukas* 1 ,
and Canadian Observational Cohort Collaboration
1 McGill Univ Hlth Ctr, Montreal, Canada;; 2 Univ Hlth Network, Toronto,
Canada;; 3 Dalla Lana Sch of Publ Hlth, Univ of Toronto, Canada;; 4 Maple
Leaf Med Clin, Toronto, Canada;; 5 Montreal Chest Inst, McGill Univ Hlth
Ctr, Canada;; 6 Clin Med l’Actuel, Montreal, Canada;; 7 Ottawa Hosp, Univ
of Ottawa, Canada;; 8 BC Ctr for Excellence in HIV/AIDS, Vancouver,
Canada;; 9 Faculty of Hlth Sci, Simon Fraser Univ, Burnaby, Canada;;
and 10 Ontario HIV Treatment Network, Toronto, Canada
+ 343
T Cell
Response to an Immunodominant Epstein-Barr Virus Epitope
A Lucas1 , V Meyer-Pannwitt1 , E McKinnon1 , S Burrows2 , M Rist2 ,
S Leary1 , M Lucas1 , S Mallal1,3 , and Elizabeth Phillips* 1,3,4
1 2 Inst for Immunology and Infectious Diseases;; Queensland Inst for Med
Res;; 3Royal Perth Hosp;; and 4Sir Charles Gairdner Hosp
336 Multiple Imputations and Bayesian Simulations
Livio Azzoni* 1 , R Barbour2 , A Violari3 , M Cotton4 , D Glencross3 ,
W Stevens3 , E Papasavvas1 , A Babiker5 , D Gibb5 , and L Montaner1 1 2 The Wistar Inst, Philadelphia, PA, US;; Yale Univ, New Haven, CT, US;;
3 4 Univ of the Witwatersrand, Johannesburg, South Africa;; Stellenbosch
Univ, Cape Town, South Africa;; and 5 346 Effect of Schistosomiasis Infection on HIV-1 Target Cells in
Jessica Prodger*
MRC, London, UK
1 , A Ssemaganda2 , N Kiwanuka2,3 , A Ssetaala2 ,
A Nanvubya2 , L Nielsen4 , P Kato2 , and R Kaul1 1 2 Univ of Toronto, Canada;; Uganda Virus Res Inst-Intl AIDS Vaccine
Initiative, Entebbe;; 3Makerere Univ Coll of Hlth Sci, Kampala Uganda;;
and 4Intl AIDS Vaccine Initiative, New York, NY, US
Program 31
Poster Listings
347
Targets of Infection During Sexual Transmission
D Stieh 1 , D Maric 1 , K Rothwangl 1 , B Beilfuss 1 , M Anderson 1 , R Veazey 2 ,
R Ruprecht 3 , F Villinger 4 , and Thomas Hope* 1
1 Northwestern Univ, Chicago, IL, US;; 2 Tulane Univ, New Orleans, LA,
US;; 3 Harvard Univ, Boston, MA, US;; and 4 Emory Univ, Atlanta, GA, US
348
in Seminal Plasma and Cervical Mucus
Susan Schader* 1 , C Gioia 1 , S Baig 1 , E Allen 1 , E Spongberg 1 , S Allen 1 ,
G Cianci 1 , D Stieh 1 , P Kiser 2 , and T Hope 1
1 Northwestern Univ, Chicago, IL, US and 2 Univ of Utah, Salt Lake City, US