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Pocket Program - CROI

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Poster Listings<br />

Session 53 <strong>CROI</strong> 2013<br />

c Monday, 2:30-4 pm; Hall B2<br />

Session 53–Poster Abstracts<br />

HIV Persistence, Reservoirs, and Viremic Control<br />

170aLB Impact of Interleukin-7 and Raltegravir + Maraviroc<br />

Intensification on Total HIV DNA Reservoir: Results from<br />

ERAMUNE 01<br />

Christine Katlama* 1 , S Lambert 2 , L Assoumou 3 , L Papagno 4 ,<br />

F Lecardonnel 4 , G Tambussi 5 , B Clotet 6 , M Youle 7 , D Costagliola 3 ,<br />

B Autran 8 , and ERAMUNE-01 Study Group<br />

1 Hosp Pitie-Salpetriere, Paris, France;; 2 Lab of Virology, Univ Pierre<br />

et Marie Curie Paris 6, INSERM U943, France;; 3 Univ Pierre et Marie<br />

Curie Paris 6, INSERM U943, France;; 4 ORVACS with the support of<br />

the Bettencourt-Schueller Fndn;; 5 San Raffaele Hosp, Milan, Italy;; 6 Hosp<br />

Univ Germans Trias i Pujol, Fndn irsiCaixa, Badalona, Spain;; 7 Royal<br />

Free Hosp NHS Trust, London, UK;; and 8 Lab of Cellular and Tissular<br />

Immunology, Univ Pierre et Marie Curie Paris 6, INSERM U945, France<br />

175LB Natural Killer Cells Can Target and Eliminate Latently<br />

HIV-1 + Primary T Cells following Proviral Reactivation<br />

Mary Ann Checkley Luttge*, C Dobrowolski, M Shukla, B Luttge,<br />

H Mao, and J Karn<br />

Sch of Med, Case Western Reserve Univ, Cleveland, OH, US<br />

+ 176LB <br />

T Cells Is<br />

Associated with Lack of Progression in Viremic Individuals<br />

Nichole Klatt* 1,2 , S Bosinger3 , A Specht4 , M Lederman5 , D Camerini6 ,<br />

M Paiardini3 , J Brenchley2 , F Kirchhoff4 , P Hunt7 , and G Silvestri3 1 2 Washington Natl Primate Res Ctr, Univ of Washington, Seattle, US;; Lab<br />

of Molecular Microbiology, NIAID, NIH, Bethesda, MD, US;; 3Yerkes Primate Res Ctr, Emory Vaccine Ctr, Emory University, Atlanta, GA, US;;<br />

4 5 Inst of Molecular Virology, Ulm Univ Med Ctr, Germany;; Case Western<br />

Reserve Univ/Univ Hosp Case Med Ctr, Cleveland, OH, US;; 6Inst for<br />

Immunology, Univ of California, Irvine, US;; and 7UCSF Positive Hlth<br />

Prgm, San Francisco, CA, US<br />

177LB <br />

Response in HIV-1 Superinfection<br />

Antoine Chaillon* 1,2 , G Wagner 1 , J Wertheim 1 , L Hepler 1 , S Kosakovsky<br />

Pond 1 , G Caballero 1 , M Pacold 3 , T Wrin 4 , D Richman 1,5 , and D Smith 1,5<br />

1 Univ of California, San Diego, La Jolla, US;; 2 INSERM UMR U966,<br />

Tours, France;; 3 Life Technologies, Foster City, CA, US;; 4 Monogram<br />

BioSci, Inc, San Francisco, CA, US;; and 5 VA San Diego Hlthcare System,<br />

CA, US<br />

24 20th Conference on Retroviruses and Opportunistic Infections<br />

c Wednesday, 2:30-4 pm; Hall B2<br />

Session 54–Poster Abstracts<br />

ART, Complications, and TB<br />

178LB <br />

<br />

Results<br />

Scott Letendre* 1 , A Mills 2 , K Tashima 3 , D Thomas 4 , S Min 4 , S Chen 4 ,<br />

I Song 4 , S Piscitelli 4 , and extended ING116070 Study Team<br />

1 UCSD Antiviral Res Ctr, San Diego, CA, US;; 2 Anthony Mills MD, Inc,<br />

Los Angeles, CA, US;; 3 The Miriam Hosp, Providence, RI, US;;<br />

and 4 GlaxoSmithKline, Research Triangle Park, NC, US<br />

170bLB Early Viral Dynamics after Cord Blood Stem Cell<br />

<br />

+ <br />

Patients<br />

M Nijhuis1 , M Kwon2 , J Kuball1 , P Ellerbroek1 , J Berenguer2 , A Stam1 ,<br />

J Symons1 , D Richman3 , JL Diez-Martin2 , Annemarie Wensing* 1 ,<br />

and European HIV Cure and Transplant Consortium<br />

1 2 Univ Med Ctr Utrecht, The Netherlands;; Gregorio Maranon G U Hosp,<br />

Madrid, Spain;; and 3Univ of California, San Diego, US<br />

171LB <br />

competent HIV Reservoirs in Perinatally Infected Youth<br />

Treated from Infancy: Towards Cure<br />

Katherine Luzuriaga* 1 , YH Chen2 , C Ziemniak2 , G Siberry3 , M Strain4 ,<br />

D Richman4 , T-W Chun5 , C Cunningham6 , and D Persaud2 1 2 Univ of Massachusetts Med Sch, Worcester, US;; Johns Hopkins Univ<br />

Sch of Med, Baltimore, MD, US;; 3Maternal and Pediatric Infectious<br />

Disease Branch, NICHD, NIH, Bethesda, MD, US;; 4Univ of California<br />

San Diego, La Jolla and VA San Diego Hlthcare System, US;; 5NIAID, NIH, Bethesda, MD, US;; and 6Duke Univ Sch of Med, Durham, NC, US<br />

172LB HIV-1 DNA Decay Patterns in Blood during More than a<br />

<br />

Guillaume Besson* 1 , C Lalama2 , R Bosch2 , R Gandhi3 , M Bedison1 ,<br />

E Aga2 , S Riddler1 , D McMahon1 , F Hong1 , and J Mellors1 1Univ of Pittsburgh Sch of Med, Division of Infectious Diseases, PA, US;;<br />

2Ctr for Biostatistics in AIDS Res, Harvard Sch of Publ Hlth, Boston, MA,<br />

US;; and 3Massachusetts Gen Hosp and Ragon Inst, Harvard Med Sch,<br />

Boston, US<br />

173LB Multifocal Detection of HIV-1 RNA in Lymphatic Tissues<br />

during Early Viral Recrudescence after Treatment Interruption<br />

Meghan Rothenberger* 1 , M Stevenson2 , G Beilman1 , J Chipman1 ,<br />

A Khoruts1 , C Fletcher3 , C Reilly1 , S Wietgrefe1 , A Haase1 , and T Schacker1 1 2 3 Univ of Minesota, Minneapolis, US;; Univ of Miami, FL, US;; and Univ<br />

of Nebraska, Omaha, US<br />

174LB A Rapid Virion Recovery Assay Reveals a Larger Population<br />

+ <br />

T Cells than<br />

Previously Recognized<br />

Michele Sobolewski* 1 , A Cillo1 , C Lalama2 , R Bosch2 , and J Mellors1 179LB <br />

<br />

<br />

Anton Pozniak*<br />

1 2 Univ of Pittsburgh, PA, US and Harvard Univ, Boston, MA, US<br />

1 , H Mingrone2 , A Shuldyakov3 , C Brites4 , J Andrade5 ,<br />

D Hagins6 , C Beltran Buendia7 , D Dorey8 , S Griffith9 , and S Min9 1 2 Chelsea and Westminster Hosp, London, UK;; Ciudad Autonoma de<br />

Buenos Aires, Argentina;; 3Saratov Regional Ctr of Prophylactic AIDS,<br />

Russian Federation;; 4Hosp Univ Professor Edgar Santos, Salvador,<br />

Brazil;; 5Hosp Civil de Guadalajare Fray Antonio Alcalde, Mexico;;<br />

6 7 Chatham CARE Ctr, Savannah, GA, US;; Hosp Barros Luco Trudeau,<br />

Santiago, Chile;; 8GlaxoSmithKline, Mississauga, Canada;;<br />

and 9GlaxoSmithKline, Research Triangle Park, NC, US<br />

180LB <br />

RTI or Raltegravir in HIV + st <br />

-<br />

<br />

Mark Boyd and SECOND-LINE Study Team<br />

The Kirby Inst, Univ of New South Wales, Sydney, Australia<br />

181LB Increasing Retention of Patients Starting ART: Karonga<br />

<br />

Rein Houben* 1 , T Mzembe2 , T van Boeckel3 , L Munthali2 , P Mzumara4 ,<br />

A Jahn5 , F Chimbwandira5 , J Glynn1 , and A Crampin1,2 1 2 London Sch of Hygiene and Tropical Med, UK;; Karonga Prevention<br />

Study, Chilumba, Malawi;; 3Univ Libre de Bruxelles, Belgium;; 4Karonga District Hosp, Malawi;; and 5Ministry of Hlth, Lilongwe, Malawi<br />

182LB Efficacy and Safety of Maraviroc to Prevent Immune<br />

Reconstitution Inflammatory Syndrome in High-risk<br />

<br />

<br />

Juan Sierra-Madero* 1 , A Tierney2 , M Rassool3 , L Azzoni4 , I Sereti5 ,<br />

J Andrade6 , L Mosqueda-Gomez7 , A Pineirua1 , I Sanne3 , M Lederman8 ,<br />

and CADIRIS Study Team<br />

1Inst Nacional de Ciencias Med y Nutricion SZ, Mexico City, Mexico;;<br />

2 3 Univ of Pennsylvania, Philadelphia, US;; Clin HIV Res Unit Faculty<br />

of Hlth Sci, Univ of the Witwatersrand;; 4The Wistar Inst, Philadelphia,<br />

PA, US;; 5NIAID, NIH, Bethesda, MD, US;; 6Hosp Civil de Guadalajara,<br />

Mexico;; 7Capasits, Leon, Mexico;; and 8Case Western Reserve Univ,<br />

Cleveland, OH, US<br />

183LB No Difference in Risk of Preterm Birth among Pregnant<br />

Ugandan Women Randomized to Lopinavir/Ritonavir vs<br />

<br />

Deborah Cohan* 1 , P Natureeba2 , A Plenty1 , F Luwedde2 , J Mwesigwa2 ,<br />

V Ades3 , B Nzarubara2 , T Clark1 , B Osterbauer1 , and E Charlebois1 1 2 Univ of California, San Francisco, US;; Infectious Disease Res<br />

Collaboration, Kampala, Uganda;; and 3New York Univ, NY, US<br />

st 184LB<br />

-Line ART Do Not Persist<br />

+ <br />

African Children:<br />

The 5-Year ARROW Trial<br />

Patricia Nahirya-Ntege* 1 , A Cook2 , V Musiime3 , A Kekitiinwa4 , K<br />

Nathoo5 , P Munderi1 , P Mugyenyi3 , S Bakeera-Kitaka4 , S Walker2 , and D Gibb2 1 2 MRC/UVRI Uganda Res Unit on AIDS, Entebbe;; MRC Clinical Trials<br />

Unit, London, UK;; 3Joint Clinical Res Ctr, Kampala, Uganda;; 4Baylor- Uganda/Paediatric Infectious Diseases Clin, Mulago, Kampala;; and<br />

5Univ of Zimbabwe, Harare<br />

185LB Non-Calcified Coronary Plaque and Macrophage Activation<br />

Markers Are Increased in HIV + Women<br />

Kathleen Fitch* 1 , S Abbara 1 , T Burdo 2 , K Williams 2 , P Eneh 1 , J Lo 1 ,<br />

and S Grinspoon 1<br />

1 Massachusetts Gen Hosp, Boston, US and 2 Boston Coll, Chestnut Hill, MA, US<br />

186LB Effect of Statins on Immune Activation and Inflammation in<br />

HIV + <br />

Trial<br />

Grace McComsey* 1,2,3 , Y Jiang 1 , S Debanne 1 , B Clagett 1 , J Robinson 1 ,<br />

D Labbato 1,2,3 , N Storer 1,2,3 , M Lederman 1,2 , and N Funderburg 1<br />

1 Case Western Reserve Univ, Cleveland, OH, US;; 2 Univ Hosp Case Med<br />

Ctr, Cleveland, OH, US;; and 3 <br />

Cleveland, OH, US<br />

187LB <br />

<br />

<br />

<br />

Craig Sponseller* 1 , R Morgan 2 , S Campbell 2 , J Aberg 3 , and M Thompson 4<br />

1 Kowa Pharmaceuticals America, Inc, Montgomery, AL;; 2 Kowa Res Inst,<br />

Inc, Morrisville, NC, US;; 3 New York Univ Sch of Med, NY, US;; and 4 AIDS<br />

Res Consortium of Atlanta, GA, US

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