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<strong>CROI</strong> 2013 Session 34<br />
e Tuesday, 4-6 pm; B406<br />
Session 33–Symposium<br />
HIV Host–Cell Interactions<br />
Conveners:<br />
Chioma Okeoma, Univ of Iowa, Iowa<br />
City, US<br />
Paul Spearman, Emory Univ, Atlanta,<br />
GA, US<br />
107<br />
Interferon-inducible Siglec, CD169, Is the<br />
Mature Dendritic Cell Receptor Essential for<br />
HIV-1 Trans-infection<br />
W Blay Puryear 1 , H Akiyama 1 , S Geer 1 , N Ramirez 1 , X Yu 2 ,<br />
B Reinhard 2 , and Rahm Gummuluru* 1<br />
1 Boston Univ Sch of Med, MA, US and 2 Boston Univ, MA, US<br />
108<br />
TRIM5 Restriction, HIV-1 Uncoating,<br />
and Relationship to Reverse Transcription<br />
Felipe Diaz-Griffero<br />
Albert Einstein Coll of Med, Bronx, NY, US<br />
109<br />
SAMHD1 Restricts HIV-1 Infection in Resting<br />
CD4 + T Cells<br />
Oliver Keppler<br />
Inst of Med Virology, Natl Reference Ctr for Retroviruses,<br />
Univ of Frankfurt, Germany<br />
110<br />
The Antiviral Activities of Tetherin<br />
RP Galao, S Pickering, A Le Tortorec, T Kueck,<br />
and Stuart Neil*<br />
Kings Coll London Sch of Med, Guys Hosp, UK<br />
Objectives: This session is directed to clinicians and scientists<br />
interested in understanding the host cell factors that promote and<br />
restrict HIV-1 replication. It is assumed that participants are familiar<br />
with cell biology, the retroviral lifecycle, and the proteins encoded<br />
in the HIV genome. At the completion of the session, participants<br />
will be knowledgeable about how dendritic cells facilitate HIV<br />
infection through their expression of specific cell-surface proteins,<br />
how host restriction proteins interfere with specific steps during<br />
virus replication, and mechanisms by which the virus has evolved to<br />
escape from these restrictions.<br />
e Tuesday, 4-6 pm; Ballroom 3-4<br />
Session 34–Symposium<br />
Reproductive Hormones and HIV<br />
Conveners:<br />
Ward Cates, FHI360, Research Triangle<br />
Park, NC, US<br />
Nelly Mugo, Univ of Washington,<br />
Nairobi, Kenya<br />
111<br />
Effects of Hormonal Contraceptives that May<br />
Affect Susceptibility to HIV Acquisition in<br />
Women<br />
Christine Mauck<br />
CONRAD, Arlington, VA, US<br />
112<br />
Assessing the Impact of Hormonal<br />
Contraceptives on HIV Risk and<br />
Prevention in Animal Models<br />
Gerardo Garcia-Lerma<br />
CDC, Atlanta, GA, US<br />
113<br />
What Have the Epidemiological Studies<br />
Taught Us about Hormonal Contraceptives<br />
and HIV-related Risks?<br />
Chelsea Polis *1 and R Heffron 2<br />
1 USAID, Office of Population and Reproductive Hlth,<br />
Washington, DC and 2 Univ of Washington, Seattle, US<br />
114<br />
<strong>Program</strong>matic Implications: Balancing<br />
Maternal Mortality and HIV Risk<br />
Jennifer Smith* 1 , A Butler 1 , C Polis 2 , S Gregson 1 , D Stanton 2 ,<br />
and T Hallett 1<br />
1 Imperial Coll London, UK and 2 US Agency for Intl Devt,<br />
Washington, DC<br />
5:30-6 pm<br />
Panel Discussion<br />
Objectives: This session is directed to clinicians and scientists<br />
interested in womens health, family planning, and HIV prevention.<br />
This session will be of interest to scientists conducting clinical<br />
studies of HIV prevention and epidemiologists evaluating risk<br />
factors for HIV acquisition and transmission. It is assumed<br />
that participants are familiar with reproductive biology and<br />
the data linking HIV risk with contraceptive hormones. At the<br />
completion of the session, participants will be knowledgeable<br />
about the epidemiologic and biologic data supporting the impact<br />
of reproductive and contraceptive hormones on HIV risk. In<br />
addition, participants will appreciate the public health impact of<br />
effective contraceptives and will learn how modeling studies have<br />
demonstrated that modest increases in HIV risk among women<br />
on hormonal contraceptives are offset by decreases in maternal<br />
mortality associated with unwanted pregnancy.<br />
<strong>Program</strong> 15<br />
Tuesday<br />
March 5 Oral Sessions