Pocket Program - CROI

Pocket Program - CROI Pocket Program - CROI

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Tuesday March 5 Oral Sessions Session 32 CROI 2013 b Tuesday, 1:30-2:30 pm; Ballroom 1-2 Session 32–Themed Discussion (see Session 130 on Monday for corresponding Poster Abstracts) Cardiovascular Disease: Predicting Risk and Monitoring Outcomes Discussants: John Brooks, CDC, Atlanta, GA, US Monica Shah, Natl Heart, Lung, and Blood Inst, NIH, Bethesda, MD,US 747 Projecting 10-year, 20-year, and Lifetime Risks of Cardiovascular Disease in HIV + Individuals in the US: Competing Risks and Premature Aging Elena Losina* 1,2,3,4 , B Linas4,5 , E Hyle1,3 , C Rusu4 , F Noubary4 , B Berkowitz4 , P Sax1,2 , M Weinstein6 , R Walensky1,2,3,4 , and K Freedberg1,3,4,5 1 2 Ctr for AIDS Res, Harvard Med Sch, Boston, MA, US;; Brigham and Womens Hosp, Boston, MA, US;; 3Massachusetts Gen Hosp, Boston, US;; 4 5 Boston Med Ctr, MA, US;; Boston Univ Sch of Publ Hlth, MA, US;; and 6Harvard Sch of Publ Hlth, Boston, MA, US 748 Improvements in Short-term Mortality following Myocardial Infarction: The Data Collection on Adverse events of Anti-HIV Drugs Study Caroline Sabin* 1 , L Ryom2 , M Law3 , W El-Sadr4 , O Kirk2,5 , M Bruyand6 , P Reiss7 , C Pradier8 , B Ledergerber9 , J Lundgren2,5 , and D:A:D Study 1 2 3 Univ Coll London, UK;; Copenhagen HIV Prgm, Denmark;; The Kirby Inst, Univ of New South Wales, Sydney, Australia;; 4Intl Ctr for AIDS Care and Treatment Prgms, Columbia Univ and Harlem Hosp, New York, NY, US;; 5Copenhagen Univ Hosp/Rigshospitalet, Denmark;; 6Univ of Bordeaux, ISPED, Ctr INSERM U897-Epidemiologie-Biostatistique, France;; 7 8 Academic Med Ctr, Univ of Amsterdam, The Netherlands;; Ctr Hosp Univ, Nice, France;; and 9Univ Hosp Zurich, Switzerland 749 ST2 and NT-proBNP Are Associated with Cardiac Dysfunction and Mortality in HIV + Individuals Eric Secemsky* 1 , R Scherzer2 , E Nitta2 , A Wu2 , D Lange2 , S Deeks2 , J Martin2 , J Snider3 , P Ganz2 , and P Hsue2 1 2 Massachusetts Gen Hosp, Boston, US;; Univ of California, San Francisco, US;; and 3Critical Diagnostics, San Diego, CA, US 750 The Risk of and Survival with Preserved vs Reduced Ejection Fraction Heart Failure by HIV Status Matthew Freiberg* 1 , C-C Chang1 , KA Oursler2,3 , J Gottdiener4 , S Gottlieb4 , A Warner5 , D Leaf5 , M Rodriguez-Barradas6,7 , S Felter8 , A Butt1,9 , and VACS Project Team 1 2 3 Univ of Pittsburgh Sch of Med, PA, US;; Baltimore VAMC, MD, US;; Univ of Maryland Sch of Med, Baltimore, US;; 4Univ of Maryland Med Ctr, Baltimore, US;; 5VA Greater Los Angeles Hlthcare System, CA, US;; 6Baylor Coll of Med, Houston, TX, US;; 7Michael E DeBakey VAMC, Houston, TX, US;; 8VA Pittsburgh Hlthcare System, PA, US;; and 9Sheikh Khalifa Med City, Abu Dhabi, United Arab Emirates 751 Emergency Medical Service Utilization and Reperfusion Times among HIV + Individuals Presenting with ST-elevation Myocardial Infarction Mark Dela Cruz* 1 , K Thomas1 , D Brenner1 , A Kulkarni2 , J McCabe3 , P Hsue1 , P Ganz1 , and S Waldo1 1 2 Univ of California, San Francisco, US;; Massachusetts Gen Hosp, Boston, US;; and 3Brigham and Womens Hosp, Boston, MA, US 14 20th Conference on Retroviruses and Opportunistic Infections C Tuesday, 2:30-4 pm; Hall B2 Poster Abstracts (see full session listings starting on page 24) Session 56. Transcription/Reverse and Forward, Splicing/Replication Session 60. Restriction Factors: APOBEC and Others Session 62. Shutting the Door on HIV Entry Session 63. Transmitted/Founder Viruses Session 66. Markers of HIV Disease Progression Session 69. CD8 T Cells in HIV Infection Session 70. Killer T Cells Session 78. Viral DNA Dynamics Session 79. Infected Cell Dynamics on Therapy Session 80. What Is Latency and What Can We Do about It? Session 82. Novel Vaccine Strategies Session 88. Neuropathogenesis Mechanisms Session 89. Central Nervous System Inflammation and Biomarkers of HIV-associated Neurocognitive Disorders Session 90. Aging and Neurocognitive Function in HIV Infection Session 94. Simian Viral Reservoirs Session 97. HIV Subtypes: Epidemiology and Disease Progression Session 99. New Approaches to ARV Drug Delivery Session 102. ARV Pharmacokinetics: New Assays, Drugs, and Special Populations Session 110. Tropism Testing/Maraviroc Resistance Session 111. HIV Drug Resistance: Trends and Emergence Session 112. Detecting and Interpreting HIV Drug Resistance Session 113. Innovation in Measuring Viral Nucleic Acids Session 114. Transmitted Drug Resistance Session 115. Drug Resistance Mutational Pathways and Subtype Associations Session 116. Advances in Sequencing and Analysis Session 117. Detecting HIV Infection Session 122. Hepatitis C Virus Treatment Today and Tomorrow Session 123. Hepatitis C Virus Resistance and Virology Session 124. Innate Immunity and Hepatitis C Virus Session 126. Hepatic Failure and Transplantation Session 127. Emergence and Persistence of HPV-associated Malignancies in the ART Era Session 133. Statin Use and HIV: How Sweet Is It? Session 134. Dyslipidemia: Risks, Pathogenesis, and Treatment Session 135. Risk Prediction, Risk Factors, Biomarkers, and Outcomes Session 137. Inflammatory Biomarkers, Microparticles, and Clinical Outcomes in HIV Session 138. ART Effects: Monocyte and T Cell Activation Session 147. TB Screening Strategies: Diagnostics New and Old and Latent TB Treatment Session 149. Mechanisms of Immune Reconstitution Session 157. Hepatitis C Virus Testing in Women Session 163. ARV Strategies, MTCT, and HIV-free Survival Session 164. PMTCT Implementation: Barriers and Program Innovations Session 167. Breast Feeding and Prevention of Postnatal MTCT Session 168. ARV Pharmacokinetics during Pregnancy and Breast Feeding Session 169. ARV Regimens and Safety during Pregnancy Session 175. HIV Drug Resistance in Children and Youth Session 176. Co-infections among HIV-infected and -exposed Children Session 184. Non-human Primate Models of STI, PrEP, and Vaccines Session 186. Implementation and Cost-effectiveness of Male Circumcision Session 188. The Ongoing Epidemic in MSM Session 193. Estimating Incidence Session 194. New Testing Strategies Session 198. Adherence and Retention in RLS

CROI 2013 Session 34 e Tuesday, 4-6 pm; B406 Session 33–Symposium HIV Host–Cell Interactions Conveners: Chioma Okeoma, Univ of Iowa, Iowa City, US Paul Spearman, Emory Univ, Atlanta, GA, US 107 Interferon-inducible Siglec, CD169, Is the Mature Dendritic Cell Receptor Essential for HIV-1 Trans-infection W Blay Puryear 1 , H Akiyama 1 , S Geer 1 , N Ramirez 1 , X Yu 2 , B Reinhard 2 , and Rahm Gummuluru* 1 1 Boston Univ Sch of Med, MA, US and 2 Boston Univ, MA, US 108 TRIM5 Restriction, HIV-1 Uncoating, and Relationship to Reverse Transcription Felipe Diaz-Griffero Albert Einstein Coll of Med, Bronx, NY, US 109 SAMHD1 Restricts HIV-1 Infection in Resting CD4 + T Cells Oliver Keppler Inst of Med Virology, Natl Reference Ctr for Retroviruses, Univ of Frankfurt, Germany 110 The Antiviral Activities of Tetherin RP Galao, S Pickering, A Le Tortorec, T Kueck, and Stuart Neil* Kings Coll London Sch of Med, Guys Hosp, UK Objectives: This session is directed to clinicians and scientists interested in understanding the host cell factors that promote and restrict HIV-1 replication. It is assumed that participants are familiar with cell biology, the retroviral lifecycle, and the proteins encoded in the HIV genome. At the completion of the session, participants will be knowledgeable about how dendritic cells facilitate HIV infection through their expression of specific cell-surface proteins, how host restriction proteins interfere with specific steps during virus replication, and mechanisms by which the virus has evolved to escape from these restrictions. e Tuesday, 4-6 pm; Ballroom 3-4 Session 34–Symposium Reproductive Hormones and HIV Conveners: Ward Cates, FHI360, Research Triangle Park, NC, US Nelly Mugo, Univ of Washington, Nairobi, Kenya 111 Effects of Hormonal Contraceptives that May Affect Susceptibility to HIV Acquisition in Women Christine Mauck CONRAD, Arlington, VA, US 112 Assessing the Impact of Hormonal Contraceptives on HIV Risk and Prevention in Animal Models Gerardo Garcia-Lerma CDC, Atlanta, GA, US 113 What Have the Epidemiological Studies Taught Us about Hormonal Contraceptives and HIV-related Risks? Chelsea Polis *1 and R Heffron 2 1 USAID, Office of Population and Reproductive Hlth, Washington, DC and 2 Univ of Washington, Seattle, US 114 Programmatic Implications: Balancing Maternal Mortality and HIV Risk Jennifer Smith* 1 , A Butler 1 , C Polis 2 , S Gregson 1 , D Stanton 2 , and T Hallett 1 1 Imperial Coll London, UK and 2 US Agency for Intl Devt, Washington, DC 5:30-6 pm Panel Discussion Objectives: This session is directed to clinicians and scientists interested in womens health, family planning, and HIV prevention. This session will be of interest to scientists conducting clinical studies of HIV prevention and epidemiologists evaluating risk factors for HIV acquisition and transmission. It is assumed that participants are familiar with reproductive biology and the data linking HIV risk with contraceptive hormones. At the completion of the session, participants will be knowledgeable about the epidemiologic and biologic data supporting the impact of reproductive and contraceptive hormones on HIV risk. In addition, participants will appreciate the public health impact of effective contraceptives and will learn how modeling studies have demonstrated that modest increases in HIV risk among women on hormonal contraceptives are offset by decreases in maternal mortality associated with unwanted pregnancy. Program 15 Tuesday March 5 Oral Sessions

Tuesday<br />

March 5 Oral Sessions<br />

Session 32 <strong>CROI</strong> 2013<br />

b Tuesday, 1:30-2:30 pm; Ballroom 1-2<br />

Session 32–Themed Discussion<br />

(see Session 130 on Monday for corresponding Poster Abstracts)<br />

Cardiovascular Disease: Predicting Risk and<br />

Monitoring Outcomes<br />

Discussants:<br />

John Brooks, CDC, Atlanta, GA, US<br />

Monica Shah, Natl Heart, Lung, and Blood Inst, NIH, Bethesda, MD,US<br />

747 Projecting 10-year, 20-year, and Lifetime Risks of<br />

Cardiovascular Disease in HIV + Individuals in the<br />

US: Competing Risks and Premature Aging<br />

Elena Losina* 1,2,3,4 , B Linas4,5 , E Hyle1,3 , C Rusu4 , F Noubary4 ,<br />

B Berkowitz4 , P Sax1,2 , M Weinstein6 , R Walensky1,2,3,4 , and K Freedberg1,3,4,5 1 2 Ctr for AIDS Res, Harvard Med Sch, Boston, MA, US;; Brigham and<br />

Womens Hosp, Boston, MA, US;; 3Massachusetts Gen Hosp, Boston, US;;<br />

4 5 Boston Med Ctr, MA, US;; Boston Univ Sch of Publ Hlth, MA, US;; and<br />

6Harvard Sch of Publ Hlth, Boston, MA, US<br />

748 Improvements in Short-term Mortality following<br />

Myocardial Infarction: The Data Collection on<br />

Adverse events of Anti-HIV Drugs Study<br />

Caroline Sabin* 1 , L Ryom2 , M Law3 , W El-Sadr4 , O Kirk2,5 , M Bruyand6 ,<br />

P Reiss7 , C Pradier8 , B Ledergerber9 , J Lundgren2,5 , and D:A:D Study<br />

1 2 3 Univ Coll London, UK;; Copenhagen HIV Prgm, Denmark;; The Kirby<br />

Inst, Univ of New South Wales, Sydney, Australia;; 4Intl Ctr for AIDS Care<br />

and Treatment Prgms, Columbia Univ and Harlem Hosp, New York, NY,<br />

US;; 5Copenhagen Univ Hosp/Rigshospitalet, Denmark;; 6Univ of Bordeaux,<br />

ISPED, Ctr INSERM U897-Epidemiologie-Biostatistique, France;;<br />

7 8 Academic Med Ctr, Univ of Amsterdam, The Netherlands;; Ctr Hosp Univ,<br />

Nice, France;; and 9Univ Hosp Zurich, Switzerland<br />

749 ST2 and NT-proBNP Are Associated with Cardiac<br />

Dysfunction and Mortality in HIV + Individuals<br />

Eric Secemsky* 1 , R Scherzer2 , E Nitta2 , A Wu2 , D Lange2 , S Deeks2 ,<br />

J Martin2 , J Snider3 , P Ganz2 , and P Hsue2 1 2 Massachusetts Gen Hosp, Boston, US;; Univ of California, San Francisco,<br />

US;; and 3Critical Diagnostics, San Diego, CA, US<br />

750 The Risk of and Survival with Preserved vs Reduced<br />

Ejection Fraction Heart Failure by HIV Status<br />

Matthew Freiberg* 1 , C-C Chang1 , KA Oursler2,3 , J Gottdiener4 ,<br />

S Gottlieb4 , A Warner5 , D Leaf5 , M Rodriguez-Barradas6,7 , S Felter8 ,<br />

A Butt1,9 , and VACS Project Team<br />

1 2 3 Univ of Pittsburgh Sch of Med, PA, US;; Baltimore VAMC, MD, US;; Univ<br />

of Maryland Sch of Med, Baltimore, US;; 4Univ of Maryland Med Ctr,<br />

Baltimore, US;; 5VA Greater Los Angeles Hlthcare System, CA, US;; 6Baylor Coll of Med, Houston, TX, US;; 7Michael E DeBakey VAMC, Houston, TX,<br />

US;; 8VA Pittsburgh Hlthcare System, PA, US;; and 9Sheikh Khalifa Med<br />

City, Abu Dhabi, United Arab Emirates<br />

751 Emergency Medical Service Utilization and<br />

Reperfusion Times among HIV + Individuals<br />

Presenting with ST-elevation Myocardial Infarction<br />

Mark Dela Cruz* 1 , K Thomas1 , D Brenner1 , A Kulkarni2 , J McCabe3 ,<br />

P Hsue1 , P Ganz1 , and S Waldo1 1 2 Univ of California, San Francisco, US;; Massachusetts Gen Hosp, Boston,<br />

US;; and 3Brigham and Womens Hosp, Boston, MA, US<br />

14 20th Conference on Retroviruses and Opportunistic Infections<br />

C Tuesday, 2:30-4 pm; Hall B2<br />

Poster Abstracts<br />

(see full session listings starting on page 24)<br />

Session 56. Transcription/Reverse and Forward, Splicing/Replication<br />

Session 60. Restriction Factors: APOBEC and Others<br />

Session 62. Shutting the Door on HIV Entry<br />

Session 63. Transmitted/Founder Viruses<br />

Session 66. Markers of HIV Disease Progression<br />

Session 69. CD8 T Cells in HIV Infection<br />

Session 70. Killer T Cells<br />

Session 78. Viral DNA Dynamics<br />

Session 79. Infected Cell Dynamics on Therapy<br />

Session 80. What Is Latency and What Can We Do about It?<br />

Session 82. Novel Vaccine Strategies<br />

Session 88. Neuropathogenesis Mechanisms<br />

Session 89. Central Nervous System Inflammation and Biomarkers<br />

of HIV-associated Neurocognitive Disorders<br />

Session 90. Aging and Neurocognitive Function in HIV Infection<br />

Session 94. Simian Viral Reservoirs<br />

Session 97. HIV Subtypes: Epidemiology and Disease Progression<br />

Session 99. New Approaches to ARV Drug Delivery<br />

Session 102. ARV Pharmacokinetics: New Assays, Drugs, and<br />

Special Populations<br />

Session 110. Tropism Testing/Maraviroc Resistance<br />

Session 111. HIV Drug Resistance: Trends and Emergence<br />

Session 112. Detecting and Interpreting HIV Drug Resistance<br />

Session 113. Innovation in Measuring Viral Nucleic Acids<br />

Session 114. Transmitted Drug Resistance<br />

Session 115. Drug Resistance Mutational Pathways and Subtype<br />

Associations<br />

Session 116. Advances in Sequencing and Analysis<br />

Session 117. Detecting HIV Infection<br />

Session 122. Hepatitis C Virus Treatment Today and Tomorrow<br />

Session 123. Hepatitis C Virus Resistance and Virology<br />

Session 124. Innate Immunity and Hepatitis C Virus<br />

Session 126. Hepatic Failure and Transplantation<br />

Session 127. Emergence and Persistence of HPV-associated<br />

Malignancies in the ART Era<br />

Session 133. Statin Use and HIV: How Sweet Is It?<br />

Session 134. Dyslipidemia: Risks, Pathogenesis, and Treatment<br />

Session 135. Risk Prediction, Risk Factors, Biomarkers, and<br />

Outcomes<br />

Session 137. Inflammatory Biomarkers, Microparticles, and Clinical<br />

Outcomes in HIV<br />

Session 138. ART Effects: Monocyte and T Cell Activation<br />

Session 147. TB Screening Strategies: Diagnostics New and Old and<br />

Latent TB Treatment<br />

Session 149. Mechanisms of Immune Reconstitution<br />

Session 157. Hepatitis C Virus Testing in Women<br />

Session 163. ARV Strategies, MTCT, and HIV-free Survival<br />

Session 164. PMTCT Implementation: Barriers and <strong>Program</strong><br />

Innovations<br />

Session 167. Breast Feeding and Prevention of Postnatal MTCT<br />

Session 168. ARV Pharmacokinetics during Pregnancy and Breast<br />

Feeding<br />

Session 169. ARV Regimens and Safety during Pregnancy<br />

Session 175. HIV Drug Resistance in Children and Youth<br />

Session 176. Co-infections among HIV-infected and -exposed Children<br />

Session 184. Non-human Primate Models of STI, PrEP, and Vaccines<br />

Session 186. Implementation and Cost-effectiveness of Male<br />

Circumcision<br />

Session 188. The Ongoing Epidemic in MSM<br />

Session 193. Estimating Incidence<br />

Session 194. New Testing Strategies<br />

Session 198. Adherence and Retention in RLS

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