ca01 only detailed ToC 1..24

4.4.27 Product Subclass 27: Æ-Haloalkylsilanes
N. J. Lawrence
4.4.27 Product Subclass 27: Æ-Haloalkylsilanes ................................. 146
145
Synthesis of Product Subclass 27 .......................................... 147
4.4.27.1 Method 1: Direct Halogenation of Alkylsilanes ........................ 147
4.4.27.1.1 Variation 1: Chlorination of Alkylsilanes ................................ 148
4.4.27.1.2 Variation 2: Bromination of Alkylsilanes ................................ 148
4.4.27.2 Method 2: Substitution of Æ-Hydroxyalkylsilanes ...................... 149
4.4.27.2.1 Variation 1: Substitution with Chloride Using Thionyl Chloride ........... 150
4.4.27.2.2 Variation 2: Chlorination of Æ-Hydroxyalkylsilanes with
Triphenylphosphine and Carbon Tetrachloride .............. 151
4.4.27.2.3 Variation 3: Iodination of Æ-Hydroxyalkylsilanes with
Methyl(triphenoxy)phosphonium Iodide .................... 151
4.4.27.3 Method 3: Haloalkylation of Halosilanes .............................. 152
4.4.27.4 Method 4: Reaction of Halosilanes with Diazomethane ................ 153
4.4.27.5 Method 5: Nucleophilic Substitution of Halo(haloalkyl)silanes .......... 154
4.4.27.6 Method 6: Alkylation of Æ-Haloalkylsilanes ............................ 155
Applications of Product Subclass 27 in Organic Synthesis ................... 155