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144 Biographical Sketch Nicholas Lawrence was born in 1963 in Chichester, West Sussex, UK. He graduated in Natural Sciences from Cambridge University in 1985. He remained at Cambridge to work with Professor Ian Fleming, FRS, gaining his Ph.D. in 1989, having investigated synthetic organosilicon chemistry and the synthesis of the pancreatic lipase inhibitor tetrahydrolipstatin (Orlistat). This was followed by postdoctoral research at Leicester University, UK, with Dr. Paul Jenkins, involving synthetic routes towards paclitaxel. He was appointed as a lecturer at UMIST in 1991 and Senior Lecturer in organic chemistry in 1997. He was appointed to a University Senior Research Fellowship at Cardiff University in 2000. His research interests include the development of new synthetic methods and the synthesis, design, and isolation (from medicinal herbs) of potential anticancer drugs. His fascination for organosilicon chemistry continues in the study of synthetic applications of polysiloxanes.
4.4.27 Product Subclass 27: Æ-Haloalkylsilanes N. J. Lawrence 4.4.27 Product Subclass 27: Æ-Haloalkylsilanes ................................. 146 145 Synthesis of Product Subclass 27 .......................................... 147 4.4.27.1 Method 1: Direct Halogenation of Alkylsilanes ........................ 147 4.4.27.1.1 Variation 1: Chlorination of Alkylsilanes ................................ 148 4.4.27.1.2 Variation 2: Bromination of Alkylsilanes ................................ 148 4.4.27.2 Method 2: Substitution of Æ-Hydroxyalkylsilanes ...................... 149 4.4.27.2.1 Variation 1: Substitution with Chloride Using Thionyl Chloride ........... 150 4.4.27.2.2 Variation 2: Chlorination of Æ-Hydroxyalkylsilanes with Triphenylphosphine and Carbon Tetrachloride .............. 151 4.4.27.2.3 Variation 3: Iodination of Æ-Hydroxyalkylsilanes with Methyl(triphenoxy)phosphonium Iodide .................... 151 4.4.27.3 Method 3: Haloalkylation of Halosilanes .............................. 152 4.4.27.4 Method 4: Reaction of Halosilanes with Diazomethane ................ 153 4.4.27.5 Method 5: Nucleophilic Substitution of Halo(haloalkyl)silanes .......... 154 4.4.27.6 Method 6: Alkylation of Æ-Haloalkylsilanes ............................ 155 Applications of Product Subclass 27 in Organic Synthesis ................... 155
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Science of Synthesis Houben-Weyl Me
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8 Science of Synthesis Category 1:
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Volume 1: Compounds withTransition
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Table of Contents Volume 2 13 Volum
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Table of Contents 15 Volume 4: Comp
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Table of Contents 17 4.4.27 Product
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2001 Georg Thieme Verlag Rüdigerst
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1.1 Product Class 1: Organometallic
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1.1 Product Class 1: Organometallic
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1.1.1 Nickel Complexes of 1,3-Diene
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1.1.1 Nickel Complexes of 1,3-Diene
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1.1.2 Nickel-Allyl Complexes 37 tra
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1.1.2 Nickel-Allyl Complexes 39 Bis
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1.1.2 Nickel-Allyl Complexes 41 App
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1.1.2 Nickel-Allyl Complexes 43 NiC
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1.1.2 Nickel-Allyl Complexes 45 Sch
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1.1.2 Nickel-Allyl Complexes 47 Sch
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1.1.3 Nickel-Alkyne Complexes 49 Ca
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1.1.3 Nickel-Alkyne Complexes 51 (2
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1.1.3 Nickel-Alkyne Complexes 53 Sc
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1.1.3 Nickel-Alkyne Complexes 55 at
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1.1.3 Nickel-Alkyne Complexes 57 Sc
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1.1.3 Nickel-Alkyne Complexes 59 en
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1.1.3 Nickel-Alkyne Complexes 61 of
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1.1.4 Nickel-Alkene Complexes 63 Bi
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1.1.4 Nickel-Alkene Complexes 65 Sc
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1.1.4 Nickel-Alkene Complexes 67 1.
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1.1.4 Nickel-Alkene Complexes 69 Sc
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1.1.4 Nickel-Alkene Complexes 71 [5
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1.1.4 Nickel-Alkene Complexes 75 4-
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References 79 References [1] Chetcu
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References 81 [98] Tsuda, T.; Mizun
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86 Biographical Sketches Rinaldo Po
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88 2.6.4.2.2 Variation 2: Two-Elect
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90 2.6 Product Class 6: Organometal
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92 Science of Synthesis 2.6 Complex
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Page 166 and 167: 166 Biographical Sketches Alan Spiv
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Page 178 and 179: 178 Abbreviations Chemical (cont.)
Page 180 and 181: 180 Abbreviations Ligands (cont.) 2
Page 182: 182 Abbreviations General (cont.) q
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