39TH ANNUAL ESDR MEETING - Konferenciakalauz
39TH ANNUAL ESDR MEETING - Konferenciakalauz
39TH ANNUAL ESDR MEETING - Konferenciakalauz
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<strong>39TH</strong> <strong>ANNUAL</strong><br />
<strong>ESDR</strong> <strong>MEETING</strong><br />
9-12 September 2009 Budapest, Hungary<br />
PROGRAM BOOK<br />
1<br />
1<br />
In partnership with:<br />
European Epidermal Barrier Research Network<br />
European Dermato-Epidemiology Network<br />
European Immunodermatology Society<br />
European Society for Pigment Cell Research<br />
European Society of Dermatopathology<br />
Fondation René Touraine<br />
www.esdr.org
Immunoglobulin<br />
as designed by nature<br />
For full prescribing information please refer to the Summary of Product Characteristics:<br />
Intratect® - Human Normal Immunoglobulin for Intravenous Administration, Ph. Eur. Composition: 1ml of solution contains: human plasma protein 50mg, thereof at least 96% is IgG, excipients: Glycine and water for<br />
injection. Indications: Replacement therapy in: Primary immunodefi ciency syndromes such as: - congenital agammaglobulinaemia and hypogammaglobulinaemia, - common variable immunodefi ciency, - severe combined<br />
immunodefi ciency, - Wiskott-Aldrich syndrome; Myeloma or chronic lymphocytic leukaemia with severe secondary hypogammaglobulinaemia and recurrent infections; Children with congenital AIDS and recurrent<br />
infections. Immunomodulation: Idiopathic thrombocytopenia purpura (ITP), in children or adults with a high risk of bleeding or prior to surgery to correct the platelet count; Guillain-Barré syndrome, Kawasaki disease.<br />
Allogeneic bone marrow transplantation. Contraindication: Hypersensitivity to any of the components. Hypersensitivity to homologous immunoglobulins especially in very rare cases of IgA defi ciency when the patient<br />
has antibodies against IgA. Special warnings and special precautions for use: Certain adverse may occur more frequently: in cases of high rate of infusion, in patients with hypo- or agammaglobulinaemia with or without<br />
IgA defi ciency, in patients who receive human normal immunoglobulin for the fi rst time or, in rare cases, when the product is switched or there is a long interval since the previous infusion. Rarely, human normal immunoglobulin<br />
can induce a fall in blood pressure with anaphylactic reaction, even in patients who had previously tolerated treatment with human normal immunoglobulin. Cases of acute renal failure have been reported<br />
in patients receiving IVIg therapy. Standard measures to prevent infections resulting from the use of medicinal products prepared from human blood or plasma include the selection of donors, screening of individual<br />
donations and plasma pools for specifi c markers of infection and the inclusion of effective manufacturing steps for the the inactivation/removal of viruses. Despite this, when medicinal products prepared from human<br />
blood or plasma are administered the possibility of transmitting infective agents cannot be totally excluded. This also applies to unknown or emerging viruses and other pathogens. Undesirable effects: Adverse reactions<br />
such as chills, headache, fever, vomiting, allergic reactions, nausea, arthralgia, low blood pressure and moderate back pain may occur occasionally. Rarely IVIg may cause a sudden fall in blood pressure and, in isolated<br />
cases, anaphylactic shock, even when the patient has shown no hypersensitivity to previous administration. Cases of reversible aseptic meningitis, isolated cases of reversible haemolytic anaemia/haemolysis, rare cases<br />
of transient cutaneous reactions, and increase in serum creatinine level and/or acute renal failure have been observed with IVIg. Very rarely thromboembolic reactions such as myocardial infarction, stroke, pulmonary<br />
embolism, deep vein thrombosis may occur.<br />
Biotest Pharma GmbH · Landsteinerstr. 5 · D-63303 Dreieich, Germany · www.biotest.de
TABLE OF CONTENTS<br />
Table of ConTenTs<br />
Acknowledgment of Sponsors of the 39th Annual <strong>ESDR</strong> Meeting 2009.............................................. 5<br />
Meeting Organisers................................................................................................................................. 5<br />
Welcome to Budapest............................................................................................................................. 7<br />
Social Program........................................................................................................................................ 8<br />
Scientific Program Highlights<br />
Major lectures................................................................................................................................... 9<br />
Postgraduate Course......................................................................................................................... 9<br />
Clinical saturday................................................................................................................................ 9<br />
esDR Meeting Digest......................................................................................................................... 9<br />
Plenary Sessions..................................................................................................................................... 11<br />
Concurrent Sessions .............................................................................................................................. 14<br />
Day-by-Day Program<br />
Wednesday 9 september.................................................................................................................. . 22<br />
Thursday 10 september. .................................................................................................................... 23<br />
friday 11 september.......................................................................................................................... 24<br />
saturday 12 september...................................................................................................................... 25<br />
Special Workshops<br />
skin Cell Migration and Invasion....................................................................................................... 26<br />
CTCl................................................................................................................................................... 27<br />
Satellite Meetings<br />
PXe..................................................................................................................................................... 28<br />
european Immuno-Dermatology society........................................................................................... 29<br />
european Pigment Cell Research society......................................................................................... 30<br />
european epidermal barrier Research network.............................................................................. 31<br />
neurobiology of the skin.................................................................................................................... 32<br />
european society for Dermatopathology........................................................................................... 33<br />
european Dermato-epidemiology network...................................................................................... 34<br />
Eastern European Session ..................................................................................................................... 35<br />
Sponsored Symposia<br />
biotest, 10 september.......................................................................................................................... 36<br />
Galderma, 11 september..................................................................................................................... 37<br />
General Information................................................................................................................................ 38<br />
Exhibitor Information<br />
list of exhibitors and map................................................................................................................ 40<br />
Poster Information/Slide Preview Room............................................................................................... 41<br />
About the <strong>ESDR</strong><br />
Current officers of the esDR board.................................................................................................. 42<br />
Past officers of the esDR board....................................................................................................... 42<br />
esDR Committees.............................................................................................................................. 43<br />
Patron Members of the esDR........................................................................................................... 43<br />
abstract Reviewers in 2009............................................................................................................... 43<br />
list of esDR awards and Honourary Memberships......................................................................... 44<br />
future esDR Meetings....................................................................................................................... 44<br />
TABLE OF CONTENTS
PLATINUM SPONSOR OF THE 2009 <strong>ESDR</strong> <strong>MEETING</strong><br />
GOLD SPONSOR OF THE 2009 <strong>ESDR</strong> <strong>MEETING</strong><br />
SPONSORS OF THE 2009 <strong>ESDR</strong> <strong>MEETING</strong><br />
astellas<br />
Ce.R.I.e.s<br />
Chanel R&T<br />
Hungarian Dermatological society<br />
Janssen-Cilag<br />
lVMH Recherche<br />
<strong>ESDR</strong> SCIENTIFIC PROGRAM COMMITTEE<br />
eugene Healy, southampton (Chair)<br />
antonio Costanzo, Rome<br />
Reinhard Dummer, Zurich<br />
alexander enk, Heidelberg<br />
alain Mauviel, Paris<br />
Vincent Piguet, Geneva<br />
<strong>ESDR</strong> OFFICE<br />
european society for Dermatological Research<br />
7 Rue Cingria<br />
CH-1205 Geneva<br />
switzerland<br />
Tel: +41 22 321 48 90<br />
fax: +41 22 321 48 92<br />
email: office@esdr.org<br />
Web: www.esdr.org<br />
CME CREDITS<br />
nékám foundation<br />
sanofi Pasteur MsD aG<br />
LOCAL ORGANISING COMMITTEE<br />
executive Committe<br />
sarolta Kárpáti, budapest (Chair)<br />
lajos Kemény, szeged<br />
Éva Remenyik, Debrecen<br />
Committe Members<br />
Zsuzsanna bata-Csörgo, szeged<br />
Zita batthyányi, Pécs<br />
antal blazsek, budapest<br />
Márta Medvecz, budapest<br />
Rolland Gyulai, szeged<br />
István Juhász, Debrecen<br />
Klaudia Preisz, budapest<br />
andrea szegedi, Debrecen<br />
Márta széll, szeged<br />
norbert Wikonkál, budapest (secretary)<br />
<strong>MEETING</strong> SECRETARIAT (PCO)<br />
MoTesZ Congress and Travel agency<br />
nádor u. 36<br />
H-1051 budapest<br />
Hungary<br />
Tel: +36 1 311 66 87<br />
fax: +36 1 383 79 18<br />
email: esdrbudapest2009@motesz.hu<br />
Web: www.motesz.hu<br />
The "39th annual esDR Meeting" is designated for a maximum of (or "for up to") 18 hours of european<br />
external CMe credits. each medical specialist should claim only those hours of credit that he/she actually<br />
spent in the educational activity. CMe certificates are available upon request at the registration desk.<br />
SPONSORS<br />
ORGANISATION
Don’t let zoster hold them back<br />
A VACCINE WILL SOON BE AVAILABLE.<br />
1. Bowsher D. The lifetime occurrence of Herpes zoster and prevalence of post-herpetic neuralgia: A retrospective survey in an 6 elderly population. Eur J Pain 1999; 3: 335–42. 2. Miller E, Marshall R,<br />
Vudien J. Epidemiology, outcome and control of varicella-zoster infection. Rev Med Microbiol 1993; 4: 222–30.<br />
6
Welcome to <strong>ESDR</strong> 2009<br />
It is our utmost pleasure to welcome you to the 39th annual<br />
Meeting of the esDR and to budapest, a city often called the<br />
Queen of the Danube. The meeting organisers selected the<br />
dynamically developing semmelweis University as main<br />
venue for this event, a place where stephen Rothman,<br />
founder of the investigative dermatology, studied.<br />
Committed to achieving the highest quality of<br />
dermatological science, the program of the budapest<br />
2009 esDR Meeting will feature over 600 posters from<br />
36 countries, plenary lectures, concurrent sessions,<br />
symposia and workshops on hot topics of research, putting<br />
forward the most recent developments in experimental<br />
dermatology.<br />
During the time of the conference the 14-acre orczy<br />
Garden park will be at our sole disposal just across the<br />
street from the meeting venue, with its lush walkways,<br />
ponds, benches, sport facilities and a running track.<br />
The Run for atopic Dermatitis, an early friday morning<br />
4km running race will be organised for those of you<br />
who wish to stay fit and balanced during the time of the<br />
conference.<br />
stephen Rothman's former piano will be exhibited at the<br />
meeting venue and every participant is free to follow in his<br />
musical footsteps.<br />
Welcome from the <strong>ESDR</strong> President<br />
The first esDR meeting in the former eastern europe, the<br />
other side of the iron curtain.<br />
Just two decades ago, it was almost impossible to organise<br />
a meeting gathering dermatologists and cutaneous<br />
biologists from western and eastern countries.<br />
This meeting marks the beginning of a new chapter in<br />
the time of these new democracies and their ambitious<br />
and intelligent people who will engage more and more in<br />
research.<br />
Today, budapest is a bridge between east and West. We<br />
hope to use it to build up new connections and encourage<br />
many young researchers in the field of dermatology to join<br />
our active society.<br />
still, there are huge problems and limitations for our<br />
colleagues in eastern europe. Unfortunately, the economic<br />
crisis is worsening the plight of many academic institutions.<br />
However, we should never forget that human intelligence<br />
and enthusiasm are the most precious gifts and,<br />
fortunately, our colleagues maintain these traits despite<br />
discouraging circumstances.<br />
one of the most important roles of the esDR is to promote<br />
the presentation of new research data and ideas at our<br />
annual scientific meeting and clinically oriented symposia.<br />
7<br />
The open-air Hungarian Gala evening will take place on<br />
friday at the bárka Theatre hidden behind the walls of<br />
the orczy Garden. at this event you will vote to decide<br />
which University Department has the best cooking skills<br />
in Hungary: Debrecen, Pécs, szeged or budapest. Thanks<br />
to the participation of the Gerbaud Kitchen’s chefs, you<br />
can give Hungarian food a real try in the marquee during<br />
the dinner. Hungarian dance classes will be available in<br />
the bárka Theatre, and you can apply your newly acquired<br />
dance knowledge in the subsequent disco or stay in the<br />
marquee for live music and dancing.<br />
budapest has always been famous for its hospitality,<br />
and the organisers will do their best during the meeting<br />
to advance this reputation and provide a comforting<br />
background for a rewarding meeting and a wonderful stay.<br />
Prof Sarolta Kárpáti<br />
Chair, local organising Committee<br />
esDR board Member<br />
This year's meeting, thanks to the outstanding effort of<br />
the scientific Program Committee, offers an exciting and<br />
stimulating program with over 200 oral presentations and<br />
over 600 posters. I encourage you to attend some of the<br />
many excellent symposia and satellite meeting sessions on<br />
offer. Your active participation is essential to the success<br />
of the meeting, so please do not hesitate to ask questions,<br />
make comments, and enjoy the hospitality offered by the<br />
budapest organisers in the evening!<br />
on behalf of the esDR I would personally like to thank all<br />
who have and will contribute to the success of this meeting,<br />
including our international guests, partner societies,<br />
sponsors and members and especially Prof sarolta Kárpáti<br />
and her team for all the engagement organising this year's<br />
meeting in beautiful budapest.<br />
Prof Reinhard Dummer<br />
President, european society for Dermatological Research<br />
WELCOME
SOCIAL<br />
PROGRAM<br />
OUTDOOR<br />
ACTIVITIES<br />
<strong>ESDR</strong> WELCOME RECEPTION<br />
Thursday 10 September 2009, 19.00-22.00<br />
all delegates are invited to attend the esDR Welcome Reception at the semmelweis University on Thursday 10<br />
september 2009. The reception will also be a first opportunity to view posters, with food and beverage stations<br />
nearby.<br />
<strong>ESDR</strong> 2009 HUNGARIAN GALA EVENING<br />
Friday 11 September 2009, 19.30-24.00<br />
Orczy Garden, Bárka Theatre Entrance (Ülloi utca 82)<br />
The 2009 esDR Gala evening will be held under a large tent in the orczy Garden and will have a strong Hungarian<br />
flavour, with music, dancing and traditional food and wine. We will also have use of the bárka Theatre a short<br />
walk away from the tent. The bárka will host Hungarian dance lessions and a DJ for those who would prefer club<br />
sounds to live music.<br />
all participants are invited to attend this relaxed and convivial event without an additional charge. Please wear<br />
comfortable and informal clothing for the evening. Hosts and hostesses will be on hand to guide you to the bárka<br />
Theatre entrance to the garden.<br />
Program (Tent)<br />
19.30 arrival at bárka Theatre entrance to garden<br />
19.30-20.20 Hungarian Cooking Competition and aperitif<br />
20.20-21.20 Dinner buffet<br />
21.20-21.30 Presentation of prizes and short speeches<br />
21.30-24.00 live music and dancing<br />
Program (Bárka Theatre)<br />
21.30-22.00 Hungarian folk Dancing lessons (studio)<br />
21.30-24.00 DJ - new Jazz-funk & bossanova (Main Theatre)<br />
Practical Info<br />
Transport<br />
at the end of the evening, taxis will be available to transport you back to hotels. for those wishing to travel by<br />
metro, the last train leaves the first stop on line 3 at 23.15. Please ask the registration desk for more information.<br />
Toilets<br />
located in the bárka Theatre.<br />
Wet Weather<br />
In case of bad weather, the party will continue but consider bringing an umbrella for the walk from the metro<br />
station to the entrance.<br />
ORCZY GARDEN - A GREEN SPACE FOR <strong>ESDR</strong> 2009<br />
Orczy Garden<br />
located opposite the esDR 2009 meeting venue, orczy Garden is a 14-hectare park comprising grassed areas,<br />
promenades, sports fields and a lake. The garden has been exclusively reserved for esDR 2009 participants as a<br />
leisure space. security guards will be monitoring the entrances and exits, so please take your meeting badge with<br />
you to access the garden.<br />
opening Hours<br />
Thursday 10 september - 07.00-17.00<br />
friday 11 september - 06.00-24.00<br />
saturday 12 september - 07.00-15.00<br />
FUN RUN FOR ATOPIC DERMATITIS<br />
Date: friday 11 september 2009<br />
location: orczy Garden running track (opposite esDR 2009 meeting venue)<br />
Time: 07.00 (meet at running track at 06.45)<br />
Distance: 4km<br />
The esDR and local organising Committee have organised a fun run for atopic dermatitis on the 400m running<br />
track opposite the esDR 2009 meeting venue. The run is open to 50 participants so please register early for<br />
this event when you arrive in budapest. several prizes will be awarded at the Gala evening on friday and all<br />
participants will receive a T-shirt. Changing rooms available by running track.<br />
This event is kindly supported by astellas.<br />
8
SCIENTIFIC AND EDUCATIONAL HIGHLIGHTS<br />
MAJOR LECTURES<br />
■ <strong>ESDR</strong> Guest Lecture: Cancer<br />
Moshe Oren (Israel)<br />
p53 and Cancer: a Complex Relationship<br />
■ Merck Serono Lecture<br />
Ronald N. Germain (USA)<br />
The Role of Cell Dynamics in Immune system<br />
function: Insights from High-resolution Intravital<br />
Imaging of lymphoid and Peripheral Tissue sites<br />
supported by<br />
■ Rudi Cormane Lecture<br />
Lars French (Switzerland)<br />
The Inflammasome, Danger sensing and skin Disease<br />
■ René Touraine Lecture<br />
Sabine Werner (Switzerland)<br />
stromal-epithelial Interactions in Wound Repair<br />
and Cancer<br />
POSTGRADUATE COURSE<br />
our knowledge in basic science is rapidly increasing.<br />
Dermatology has numerous interfaces with basic<br />
science fields. Thus, a constant update in these areas is<br />
crucial for the further development of dermatological<br />
research. The purpose of the Postgraduate Course is<br />
to provide overviews about primarily non-dermatologic<br />
topics that are relevant for experimental and clinical<br />
dermatology. These talks are principally intended as<br />
essential updates for “non-experts”.<br />
Program<br />
10 september 2009, 11.00-12.30<br />
Chairs: Tilo biedermann, Robert Gniadecki<br />
■ Eva Mezey (Bethesda)<br />
stem Cells: bumpy Road from bench to bedside<br />
■ Carien Niessen (Cologne)<br />
Intercellular adhesion and Polarity in skin<br />
Morphogenesis and Pathogenesis<br />
■ Miklós Palkovits (Budapest)<br />
bilateral Connections between the autonomic<br />
nervous system and the structures of the<br />
epidermis<br />
<strong>ESDR</strong> <strong>MEETING</strong> DIGEST<br />
Saturday 12 September 2009, 14.15-15.15<br />
Speakers: John McGrath, Martin Röcken, Thomas Schwarz<br />
9<br />
CLINICAL SATURDAY<br />
The main mission of the esDR is to foster basic<br />
research in dermatology and skin biology. To increase<br />
the exchange between basic scientists and clinicians<br />
at the annual meeting, the esDR has included a<br />
“Clinical saturday” as part of the regular program.<br />
by offering Clinical saturday and industry sponsored<br />
symposia, the esDR hopes to make the meeting as<br />
attractive for clinicians as it always has been for basic<br />
scientists. The esDR feels committed to satisfying the<br />
needs and interests of both scientists and clinicians.<br />
The dialogue and cross fertilization between these<br />
two groups is essential for the future prosperous<br />
development of dermatology.<br />
Clinical saturday 2009 is held in association with the<br />
european academy for Dermatology and Venereology<br />
Program<br />
Clinical saturday I: 12 september 2009, 08.45-10.15<br />
Chairs: Carlo Pincelli, Peter steijlen<br />
■ Pascal Joly (Rouen)<br />
novel Cinical and Therapeutic advances in<br />
autoimmune bullous Diseases<br />
■ Christos Zouboulis (Dessau)<br />
Inflammatory Diseases of sebaceous Glands<br />
■ Sarolta Kárpáti (Budapest)<br />
skin barrier Damage due to enzyme Dysfunctions<br />
Clinical saturday II: 12 september 2009, 11.15-12.45<br />
Chairs: sarolta Kárpáti, erwin Tschachler<br />
■ Stefan Beissert (Münster)<br />
The Role of Regulatory T cells in<br />
Photocarcinogenesis<br />
■ Giovanna Zambruno (Rome)<br />
Update on Inherited epithelial adhesion<br />
Disorders<br />
■ Mona Ståhle (Stockholm)<br />
Genetic susceptibility in Psoriasis<br />
The esDR Meeting Digest is a one-hour summary and analysis of scientific highlights of the 2009 meeting as<br />
seen by three senior scientists. each speaker will focus on a different topic area, extracting important results<br />
from abstracts submittted to the meeting and placing them into a wider context.<br />
SCIENTIFIC<br />
HIGHLIGHTS<br />
<strong>ESDR</strong><br />
DIGEST
PLENARY SESSION I: THURSDAY 10 SEPTEMBER 2009, 14.00-16.00<br />
SEMMELWEIS ROOM<br />
Chairs: Hiroshi Shimizu, Georg Stingl<br />
Talk duration is 12 minutes plus 3 minutes questions<br />
Oral 001 [Poster 218]<br />
A dynamic subpopulation of slow-proliferating JARID1B-positive cells is required for long-term<br />
self-renewal of melanoma but not for initial tumor formation<br />
Roesch a 1 , fukunaga-Kalabis M 2 , schmidt b 2 , Zabierowski s 2 , Vogt T 1 , Herlyn M 2 1 Regensburg Univ<br />
Medical Center, Germany 2 The Wistar Institute, Philadelphia, Usa<br />
Oral 002 [Poster 262]<br />
Both hematopoietic and mesenchymal stem cells contribute to the production of basement<br />
membrane protein in bone marrow transplantation treatment model mouse<br />
fujita Y 1 , abe R 1 , Inokuma D 1 , nishie W 1 , nakamura H 1 , akiyama M 1 , sawamura D 2 , shimizu H 1<br />
1 Hokkaido University Graduate school of Medicine, sapporo, Japan 2 Hirosaki University Graduate<br />
school of Medicine, Hirosaki, Japan<br />
Oral 003 [Poster 598]<br />
An amplifying circuit of the innate immune sensing of Staphylococcus aureus: Monomeric<br />
peptidoglycan functions as NOD2 ligand and aggravates TLR mediated inflammation<br />
Volz T 1 , nega M 2 , buschmann J 2 , Kaesler s 1 , Guenova e 1 , Röcken M 1 , Götz f 2 , biedermann T 1<br />
1 Department of Dermatology, University Hospital Tübingen, Germany 2 Department of Microbial<br />
Genetics, eberhard Karls University, Tübingen, Germany<br />
Oral 004 [Poster 458]<br />
Fetal cells persist in maternal chronic wounds, form blood vessels and enhance healing<br />
nassar D, Droitcourt C, Parant o, Mathieu-d’argent e, oster M, Uzan s, Khosrotehrani K, aractingi s<br />
UPMC Univ Paris 6, InseRM UMRs 938, centre de recherche saint antoine, fetal stem cells unit, Paris,<br />
france<br />
Oral 005 [Poster 599]<br />
HIV-1 induces cdc42-dependent filopodia formation to facilitate dendritic cell-t cell trans-infection<br />
nikolic Ds, lehmann M, Garcia e, blanchet fP, Piguet V Department of Dermatology and<br />
Venereology, University Hospitals, Geneva, switzerland<br />
Oral 006 [Poster 186]<br />
A mutation in the histidase gene sensitizes mice to UVB-induced DNA damage: evidence for the<br />
photoprotective role of endogenously produced urocanic acid<br />
barresi C 1 , stremnitzer C 1 , Mlitz V 1 , Kezic s 2 , Ghannadan M 1 , buchberger M 1 , Mildner M 1 , selden<br />
C 3 , Tschachler e 1 , eckhart l 1 1 Medical University of Vienna, Vienna, austria 2 Coronel Institute,<br />
amsterdam, netherlands 3 UCl Medical school, london, UK<br />
Oral 007 [Poster 469]<br />
HIF-1alpha knockdown keratinocytes cannot reconstruct a viable epidermis<br />
ali n 1 , Rezvani H 1 , Varon C 2 , Pain C 1 , Taieb a 1 , De Verneuil H 1 , Mazurier f 1 1 Inserm U876 - Univ.<br />
bordeaux2 , france 2 CnRs UMR5164- Univ. bordeaux2, france<br />
Oral 008 [Poster 263]<br />
Heterogenetic parabiosis and skin grafting murine models (Abcc6-/-) support the metabolic nature<br />
of pseudoxanthoma elasticum<br />
Uitto J, Jiang Q Jefferson Medical College, Philadelphia, Usa<br />
11<br />
PLENARY<br />
SESSIONS
PLENARY<br />
SESSIONS<br />
PLENARY SESSION II: FRIDAY 11 SEPTEMBER 2009, 08.30-11.00<br />
SEMMELWEIS ROOM<br />
Chairs: Martine Bagot, Jouni Uitto<br />
Talk duration is 12 minutes plus 3 minutes questions<br />
Oral 009 [Poster 001]<br />
Generation of myeloid derived suppressor cells during the progression of murine RET melanoma<br />
fujimura T 1 , Mahnke K 1 , Ring s 1 , Umansky V 2 , aiba s 3 , enk aH 1 1 University of Heidelberg, Heidelberg,<br />
Germany 2 German Cancer Research Center, Heidelberg, Germany 3 Tohoku University, Graduate school of<br />
Medicine, sendai, Japan<br />
Oral 010 [Poster 499]<br />
Identification of a novel microRNA regulator of keratinocyte migration and proliferation in wound healing<br />
bertero T 1 , bourget-Ponzio I 1 , loubat a 1 , Techer n 1 , Mari b 2 , barbry P 2 , Meneguzzi G 1 , Ponzio G 1 , Rezzonico R 1<br />
1 InseRM U634, nice, france 2 CnRs UMR 6097, sophia-antipolis, france<br />
Oral 011 [Poster 470]<br />
Cytoskeletal protein Flightless I affects cellular adhesion and blister formation in epidermolysis bullosa<br />
Kopecki Z 1 , arkell R 2 , ludwig R 3 , Zillikens D 3 , Murrell D 4 , Cowin aJ 1 1 Women’s & Children’s Health Research<br />
Inst, north adelaide, australia 2 Molecular Genetics & evolution Group australian nat Univ, aCT, australia 3 Dept<br />
of Dermatology Univ of lubeck, Germany 4 Dept of Dermatology st. George Hospital, sydney, australia<br />
Oral 012 [Poster 002]<br />
Vaccination against autoimmune disease through in vivo silencing of dendritic cells with a specific IL-12/<br />
IL23p40 si-RNA<br />
brück J 1 , Weigert C 1 , Pascolo C 2 , Glocova I 1 , fuchs K 1 , Ghashghaeinia M 1 , Hötzenecker W 1 , Ghoreschi K 1 ,<br />
Röcken M 1 1 Department of Dermatology, Tübingen, Germany 2 University Hospital of Zürich, oncology, Zürich,<br />
switzerland<br />
Oral 013 [Poster 521]<br />
Autoantibody-induced intestinal inflammation and weight loss in experimental epidermolysis bullosa<br />
acquisita<br />
Ishii n 1 , Recke a 2 , Mihai s 2 , Hirose M 2 , Hashimoto T 1 , Zillikens D 2 , ludwig RJ 2 1 Kurume Univ school of<br />
Medicine, Kurume, Japan 2 University of lübeck, Germany<br />
Oral 014 [Poster 003]<br />
Essential roles of actin cytoskeleton formation through mDia1 in skin dendritic cell functions<br />
Hideaki T, Gyohei e, shuh n, Yoshiki M, Kenji K Kyoto University, Kyoto, Japan<br />
Oral 015 [Poster 471]<br />
Cadherin mediated regulation of the tight junctional skin barrier function<br />
Michels C, buchta T, niessen C University of Cologne, Cologne, Germany<br />
Oral 016 [Poster 393]<br />
Differentiation of epidermal keratinocytes from mouse induced pluripotent stem cells<br />
nakamura M, Tokura Y University of occupational and environmental Health, Kitakyushu, Japan<br />
Oral 017 [Poster 331]<br />
Activated Langerhans cells capture external antigens by sending their dendrites out through epidermal tight<br />
junctions<br />
Kubo a 1 , nagao K 1 , Yokouchi M 1 , sasaki H 2 , amagai M 1 1 school of Medicine, Keio University, Tokyo, Japan 2 The<br />
Jikei University school of Medicine, Tokyo, Japan<br />
Oral 018 [Poster 420]<br />
IL-21-activated STAT3 upregulates microRNA-21 expression in CD4+ T cells: pathologically involved in<br />
cutaneous T cell lymphoma?<br />
van der fits l, van Kester Ms, out JJ, smit f, Willemze R, Tensen CP, Vermeer MH lUMC, leiden, netherlands<br />
12
PLENARY SESSION III: FRIDAY 11 SEPTEMBER 2009, 17.00-18.30<br />
SEMMELWEIS ROOM<br />
Chairs: Ervin Epstein, Jean-Hilaire Saurat<br />
Talk duration is 12 minutes plus 3 minutes questions<br />
Oral 019 [Poster 522]<br />
IL-21, a new player in pathogenesis of psoriasis<br />
botti e 1 , Caruso R 2 , sarra M 2 , Diluvio l 1 , Pallone f 2 , Chimenti s 1 , Monteleone G 2 , Costanzo a 1 1 University of<br />
Rome Tor Vergata Dermatology, Rome, Italy 2 University of Rome Tor Vergata Gastroenterology, Rome, Italy<br />
Oral 020 [Poster 174]<br />
Betapapillomavirus infection and cutaneous squamous-cell carcinoma<br />
bouwes bavinck J 1 , neale R 2 , abeni D 3 , de Koning M 4 , Pawlita M 5 , Pfister H 6 , naldi l 7 , Harwood C 8 , Green<br />
a 2 , feltkamp M 1 1 leiden Univ Medical Center, leiden, netherlands 2 Queensland Inst of Medical Research,<br />
brisbane, australia 3 Istituto Dermopatico dell’Immacolata, IDI-IRCCs, Rome, Italy 4 DDl Diagnostic lab, Voorburg,<br />
netherlands 5 German Cancer Research Center (DKfZ), Heidelberg, Germany 6 Inst of Virology, Univ of Cologne,<br />
Germany 7 Dept of Dermatology & GIseD study Center, bergamo, Italy 8 Queen Mary Univ of london, UK<br />
Oral 021 [Poster 264]<br />
Filaggrin-deficient mice have an inherent skin barrier defect and recapitulate key features of atopic eczema<br />
fallon PG 1 , Irvine aD 1 , sasaki T 2 , sandilands a 3 , saunders sP 1 , Presland Rb 4 , fleckman P 4 , Kudoh J 2 ,<br />
amagai M 2 , Mclean I 3 1 Trinity College Dublin, Dublin, Ireland 2 Keio University, Tokyo, Japan 3 University of<br />
Dundee, Dundee, United Kingdom 4 University of Washington, seattle, Usa<br />
Oral 022 [Poster 265]<br />
Long term genetic correction of cancer prone xeroderma pigmentosum skin ex vivo and in vivo<br />
Magnaldo T 1 , Warrick e 2 , Garcia M 3 , bergoglio V 4 , larcher f 3 , Del Rio M 3 , bernerd f 5 1 CnRs, fRe 3086,<br />
faculté de Médecine, nice, france 2 CnRs, fRe 3086, faculté de Médecine, l’oréal france, nice, france<br />
3 CIeMaT-CIbeR de enfermedades Raras, Madrid, spain 4 CnRs, fRe 3086, faculté de Médecine, nice, spain<br />
5 l’oreal advanced Research, Clichy, france<br />
Oral 023 [Poster 394]<br />
Regeneration of hair and epidermis by the receptor activator of NF-kappaB<br />
Mueller C 1 , Duheron V 2 , Hess e 2 , amoasii l2, Paus R 3 1 University of strasbourg, CnRs, strasbourg, france<br />
2 University of strasbourg, strasbourg, france 3 University of lübeck, lübeck, Germany<br />
Oral 024 [Poster 187]<br />
Langerhans cells are required for UV-induced immunosuppression<br />
schwarz a 1 , noordegraaf M 2 , Clausen b 2 , schwarz T 1 1 University Kiel, Kiel, Germany 2 University Rotterdam,<br />
Rotterdam, netherlands<br />
13<br />
PLENARY<br />
SESSIONS
CONCURRENT<br />
SESSIONS<br />
CONCURRENT SESSION I: Immunology<br />
Thursday 10 September 2009, 17.00-18.30<br />
SEMMELWEIS ROOM<br />
Chairs: Alexander Enk, Peter Friedmann<br />
Talk duration is 8 minutes plus 2 minutes questions.<br />
Oral 025 [Poster 004]<br />
Adenosine produced by CD4+CD25+ regulatory T cells suppresses contact hypersensitivity reactions by<br />
engaging the A1 adenosine receptor on vascular endothelium<br />
Ring s 1 , oliver s 2 , Cronstein b 2 , enk aH 1 , Mahnke K 1 1 University Hospital Heidelberg, Heidelberg, Germany<br />
2 new York University school of Medicine, new York, Usa<br />
Oral 026 [Poster 005]<br />
The RhoA effector mDia1 regulate motility and function in T lymphocytes<br />
egawa G 1 , Tanizaki H 1 , okada T 2 , narumiya s 1 , Miyacchi Y 1 , Kabashima K 1 1 Kyoto University, Kyoto, Japan<br />
2 RIKen, Yokohama, Japan<br />
Oral 027 [Poster 006]<br />
Local UVB-induced immunosuppression is mediated by IL-10-produing and OX40L-positive mature<br />
Langerhans cells<br />
Yoshiki R 1 , Kabashima K 2 , sugita K 1 , nakamura M 1 , Tokura Y 1 1 University of occupational and environmental<br />
Health, Kitakyushu, Japan 2 Kyoto University, Kyoto, Japan<br />
Oral 028 [Poster 007]<br />
The role of mast cells in contact hypersensitivity using newly-generated mast cell-specific conditional<br />
depletion model<br />
otsuka a, Miyachi Y, Kabashima K Kyoto University, Kyoto, Japan<br />
Oral 029 [Poster 008]<br />
Surgical denervation of skin in the KC-Tie2 mouse model of psoriasis eliminates dendritic cell infiltrate,<br />
decreases IL-23 protein expression and improves acanthosis<br />
ostrowski sM, belkadi aM, Matheny C, Diaconu D, Wolfram Ja, Hatala Da, Ward nl Case Western Reserve<br />
University, Cleveland, Usa<br />
Oral 030 [Poster 009]<br />
Alteration of the migratory behavior of UV-induced regulatory T cells in vivo<br />
schwarz a, schuller W, schwarz T University of Kiel, Kiel, Germany<br />
Oral 031 [Poster 010]<br />
IL-4 therapy of psoriasis selectively abrogates IL-23 and TH17 immune responses in humans<br />
Guenova e 1 , Ghoreschi K 1 , Hötzenecker W 1 , sauer K 1 , Weindl G 2 , Tham M 1 , schäkel K 3 , schaller M 1 , Röcken M 1 ,<br />
biedermann T 1 1 eberhard Karls University Tübingen, Germany 2 freie Universität berlin, Germany 3 Technische<br />
Universität Dresden, Germany<br />
Oral 032 [Poster 011]<br />
Th22 cells represent a distinct human T lymphocyte subset of tissue-signaling leukocytes<br />
eyerich K 1 , foerster s 2 , Pennino D 3 , Carbone T 3 , Cianferani f 4 , odorisio T 4 , Traidl-Hoffmann C 1 , Durham s 5 ,<br />
schmidt-Weber C 2 , Cavani a 3 1 ZaUM – Center for allergy & environment, Div of environmental Dermatology<br />
& allergy HHZ/TUM, Munich, Germany 2 Molecular Immunology, Dept of allergy & Clinical Immunology, nHlI,<br />
Imperial College, london, UK 3 lab of Immunology, Istituto Dermopatico dell’Immacolata, IRCCs, Rome,<br />
Italy 4 lab of Cellular & Molecular biology, Istituto Dermopatico dell’Immacolata, IRCCs, Rome, Italy 5 Upper<br />
Respiratory Medicine, Dept of allergy & Clinical Immunology, nHlI, Imperial College, london, UK<br />
Oral 033 [Poster 012]<br />
The functional spectrum of cytotoxic DCs: different roles of IFNα and MHC I in pDCs and mDCs<br />
Kalb M, stary G, Koszik f, stingl G Department of Dermatology, DIaID, Medical University of Vienna, Vienna,<br />
austria<br />
14
CONCURRENT SESSION II: Clinical Investigation and Epidemiology<br />
Thursday 10 September 2009, 17.00-18.30<br />
KAPOSI ROOM<br />
Chairs: Jan Nico Bouwes Bavinck, Nick Reynolds<br />
Talk duration is 8 minutes plus 2 minutes questions.<br />
Oral 034 [Poster 090]<br />
The effects of filaggrin mutations on barrier function in eczema patients<br />
abdul Ghaffar s 1 , Tan sP 1 , Campbell le 2 , lee lH 1 , sergeant a 1 , Mclean WI 1 , Weller R 1 1 The University of<br />
edinburgh, UK 2 University of Dundee, UK<br />
Oral 035 [Poster 091]<br />
Are the superantigens producing Staphylococcus aureus strains more resistant to antimicrobial peptides?<br />
baranska-Rybak W 1 , szultka l 1 , sokolowska-Wojdylo M 1 , naumiuk l 2 , nowicki R 1 , Kamysz W 1 , Roszkiewicz J 1<br />
1 Med Univ, Gdansk, Poland 2 lipopharm, Zblewo, Poland<br />
Oral 036 [Poster 092]<br />
The use of Sulfasalazine and Pentoxiphylline as an adjuvant therapy for the treatment of Pemphigus Vulgaris:<br />
A comparative study<br />
el Darouti M, Marzouk s, abdel Hay R, el Tawdy a, fawzy M, leheta T, Gammaz H, al Gendy n faculty of<br />
Medicine, Cairo University, Cairo, egypt<br />
Oral 037 [Poster 093]<br />
Switching azathioprine to mycophenolate reduces UVA photosensitivity in renal transplant recipients<br />
Hofbauer G 1 , straub G 1 , Meyer R 1 , Karran P 2 , attard n 2 , french l 3 , Wüthrich R 3 , serra a 3 1 Univ Hosp Zurich,<br />
Dept of Derm, switzerland 2 Cancer Res UK london Res Inst, Clare Hall labs, Herts, UK 3 Univ Hosp Zurich, Div<br />
of nephrology, switzerland<br />
Oral 038 [Poster 094]<br />
Expression of epidermal differentiation and antimicrobial proteins after treatment with pimecrolimus versus<br />
betamethasone in atopic dermatitis<br />
Jensen J 1 , scherer a 2 , bräutigam M 2 , Gläser R 1 , Witt M 1 , fölster-Holst R 1 , Proksch e 1 1 University of Kiel,<br />
Kiel, Germany 2 novartis Pharma, basel, switzerland<br />
Oral 039 [Poster 095]<br />
A risk-benefit assessment of Adalimumab, Etanercept, and Infliximab in psoriasis<br />
strober b 1 , langley R 2 , Rozzo s 3 1 new York University school of Medicine, new York, new York, Usa<br />
2 Dalhousie University, Halifax, nova scotia, Canada 3 abbott laboratories, abbott Park, Illinois, Usa<br />
Oral 040 [Poster 166]<br />
Investigation of cell therapy for generalized severe recessive dystrophic epidermolysis bullosa by<br />
intradermal allogeneic fibroblasts randomized against placebo injections<br />
Yan Wf 1 , Venugopal s 1 , frew JW 1 , Tran K 2 , sturm M 3 , fogarty J 3 , Marinkovich P 4 , Igawa s 5 , Ishida-Yamamoto a 5 ,<br />
Murrell Df 1 1 st George Hospital, Univ of nsW, australia 2 seals, st George Hosp, Univ of nsW, sydney, australia<br />
3 Cell and Tissue Therapies Wa, Royal Perth Hosp, Perth, australia 4 stanford Univ, stanford, Usa 5 asahikawa<br />
Medical College, Japan Chairs: Jan nico bouwes bavinck, nick Reynolds<br />
Oral 041 [Poster 175]<br />
Temporal patterns of disease in eczema: the failure of objective and subjective measures of disease activity<br />
to match<br />
Murray Cs, Rees Jl The University of edinburgh, edinburgh, United Kingdom<br />
Oral 042 [Poster 176]<br />
Psoriasis is not associated with an increased risk of cardiovascular hospitalizations: results of a large<br />
population based Dutch cohort<br />
Wakkee M, Herings R, nijsten T erasmus Medical Center, Rotterdam, netherlands<br />
15<br />
CONCURRENT<br />
SESSIONS
CONCURRENT<br />
SESSIONS<br />
CONCURRENT SESSION III: Photobiology, Pigmentation and Melanoma<br />
Thursday 10 September 2009, 17.00-18.30<br />
GRUBY ROOM<br />
Chairs: Eugene Healy, Mauro Picardo<br />
Talk duration is 8 minutes plus 2 minutes questions.<br />
Oral 043 [Poster 219]<br />
Micro-array analysis reveals that melanocortin 1 receptor is down-regulated by SLC24A5 knock-down in<br />
normal human melanocytes<br />
Wilson s, askew se, lim fl, Gunn Da, Ginger Rs, Green MR Unilever R&D, bedford, United Kingdom<br />
Oral 044 [Poster 188]<br />
In vivo antagonism of the aryl hydrocarbon receptor prevents UV-induced immunosuppression<br />
schuller W, schwarz T, schwarz a University Clinics schleswig-Holstein, Campus Kiel, Kiel, Germany<br />
Oral 045 [Poster 189]<br />
The pro-apoptotic role of RAIDD in vitro and in vivo<br />
schuepbach-Mallepell s 1 , Roques s 1 , logette e 2 , Tschopp J 2 , Gaide o 1 1 Geneva University Hospital,<br />
switzerland 2 University of lausanne, switzerland<br />
Oral 046 [Poster 220]<br />
c-Kit Mutants Require Hypoxia-Inducible Factor 1α to Transform Melanocytes<br />
Monsel G 1 , ortonne n 2 , bagot M 2 , bensussan a 1 , Dumaz n 1 1 InseRM U976, Paris, france 2 Hôpital Henri<br />
Mondor, Créteil, france<br />
Oral 047 [Poster 190]<br />
Treg/Th17 axis in 8-methoxypsoralen plus ultraviolet-A response of a psoriasis-like skin disorder in mice<br />
singh TP 1 , schön MP 2 , Michaelis K 3 , Wang XJ 4 , Wolf P 1 1 Dept of Derm, Med Univ of Graz, austria 2 Dept of<br />
Derm, Univ Med Ctr Göttingen, Germany 3 Univ of Würzburg, Germany 4 Dept of Path, Head & neck Cancer Res,<br />
Univ of Colorado Denver, Usa<br />
Oral 048 [Poster 221]<br />
AP-1 inhibition identifies cooperation of INK4 and Cip/Kip signaling pathways to suppress human melanoma<br />
Jalili a 1 , Wagner C 1 , Mertz KD 1 , Pashenkov M 1 , lupien M 2 , brunet JP 3 , Ramaswamy s 4 , Golub TR 3 , stingl<br />
G 1 , Wagner sn 1 1 DIaID, Dept of Dermatology, Medical Univ of Vienna, austria 2 norris Cotton Cancer Center,<br />
Dartmouth-Hitchcock Med Center, lebanon, Usa 3 The broad Inst of MIT & Harvard, Cambridge, Usa<br />
4 Massachusetts General Hosp Center for Cancer Research & Dept of Medicine, Charlestown, Usa<br />
Oral 049 [Poster 222]<br />
Ebselen induces peripheral actin depolymerisation and inhibits melanosomal transfer through a melanocytedependent<br />
mechanism<br />
Kasraee b, nikolic D, salomon D, Piguet V, fontao l, sorg o, saurat JH Geneva University Hospital, switzerland<br />
Oral 050 [Poster 223]<br />
GLI2, A TGF-beta-Inducible Target, Promotes Melanoma Invasion and Metastasis<br />
alexaki VI, Javelaud D, Dennler s, Verrecchia f, Mauviel a InseRM U697, Paris, france<br />
Oral 051 [Poster 224]<br />
Functional melanocortin 1 receptors are located in the melanosome of pigment cells<br />
Jackson Cl 1 , singh s 2 , Robinson sJ 1 , Kumar P 1 , Page aM 1 , friedmann Ps 1 , Tobin DJ 2 , Healy e 1 1 University of<br />
southampton, UK 2 University of bradford, UK<br />
16
CONCURRENT SESSION IV: Genetic Disease, Gene Expression and Gene Therapy<br />
Thursday 10 September 2009, 17.00-18.30<br />
NEKAM ROOM<br />
Chairs: John McGrath, Takashi Hashimoto<br />
Talk duration is 8 minutes plus 2 minutes questions.<br />
Oral 052 [Poster 266]<br />
In vitro correction of COL7A1 gene mutations using RNA trans-splicing<br />
Murauer eM 1 , Gache Y 2 , Gratz IK 1 , Klausegger a 1 , Muss W 3 , Gruber C 1 , Meneguzzi G 2 , Hintner H 4 , bauer JW 1<br />
1 laboratory for Molecular Therapy, eb-house austria, Univ Hospital salzburg, austria 2 InseRM U634, faculty<br />
of Medicine, Univ of nice-sophia antipolis, nice, france 3 Institute of Pathology, Univ Hospital salzburg, austria<br />
4 eb-house austria, Department of Dermatology, Univ Hospital salzburg, austria<br />
Oral 053 [Poster 267]<br />
Plectin expression in epidermolysis bullosa simplex (EBS) with muscular dystrophy vs. in EBS with pyloric<br />
atresia<br />
natsuga K 1 , nishie W 1 , akiyama M 1 , ouchi T 3 , Ishiko a 3 , Hirako Y 4 , owaribe K 4 , bruckner-Tuderman l 2 ,<br />
shimizu H 1 1 Hokkaido Univ Graduate school of Medicine, sapporo, Japan 2 Univ Medical Center freiburg,<br />
Germany 3 Keio Univ school of Medicine, Tokyo, Japan 4 nagoya Univ Graduate school of science, Japan<br />
Oral 054 [Poster 268]<br />
Hereditary Painful Callosities, a form of Palmar-Plantar Keratoderma, is caused by dominant negative<br />
mutations in the 2B helix of keratin K6c<br />
easter Te, Ruge f, bowden Pe Cardiff University, Cardiff, United Kingdom<br />
Oral 055 [Poster 269]<br />
Plectin mutations underlie epidermolysis bullosa simplex in patients with wild type KRT5 and KRT14 alleles<br />
bolling MC 1 , Jongbloed JD 1 , smith fJ 2 , Mclean WH 2 , Jonkman Mf 1 1 University Medical Center Groningen,<br />
netherlands 2 University of Dundee, UK<br />
Oral 056 [Poster 270]<br />
Functional restoration of inherited epidermolysis bullosa by bone marrow-derived adult stem cells<br />
Ghoreschi K 1 , Huenefeld C 1 , Glocova I 1 , Mueller-Hermelink e 1 , fehrenbacher b 1 , biedermann T 1 , amagai M 2 ,<br />
Manz MG 3 , schaller M 1 , Röcken M 1 1 eberhard Karls University, Tübingen, Germany 2 Keio University school of<br />
Medicine, Tokyo, Japan 3 Institute for Research in biomedicine, bellinzona, switzerland<br />
Oral 057 [Poster 271]<br />
Cross talk between p63 and IRF6 in the regulation of keratinocyte proliferation<br />
Moretti f 1 , spallone G 1 , botti e 1 , Merlo G 2 , Chimenti s 1 , alemà s 3 , Guerrini l 4 , Costanzo a 1 1 Dept of<br />
Dermatology University of Rome Tor Vergata, Italy 2 Molecular biotechnology Center, DTI, University of Turin,<br />
Italy 3 Cellular biology Institute, CnR, Rome, Italy 4 Cellular and Developmental biology, University of Milan, Italy<br />
Oral 058 [Poster 272]<br />
Mutations in either the OSMR or IL31RA genes underlie familial primary cutaneous amyloidosis<br />
Tsai s 1 , lin M 2 , lee D 3 , McGrath J 4 1 national Health Research Institutes, Zhunan, Miaoli County, Taiwan<br />
2 national Yang-Ming University, Taipei, Taiwan 3 Taipei Veterans General Hospital, Taipei, Taiwan 4 st John’s<br />
Institute of Dermatology, london, UK<br />
Oral 059 [Poster 273]<br />
Microarray profiling in EEC ectodermal dysplasia syndrome skin reveals increased fatty acid-binding protein<br />
FABP7 and reduced hair/nail keratin gene expression<br />
Clements se, Techanukul T, Mellerio Je, McGrath Ja st Johns Institute of Dermatology, london, UK<br />
Oral 060 [Poster 274]<br />
High-throughput mutation profiling of CTCL samples using OncoMap<br />
oberholzer Pa 1 , Karpova Mb 2 , Zipser MC 2 , lin WM 3 , Girardi M 3 , MacConaill le 1 , Kehoe sM 4 , Garraway la 1 ,<br />
Dummer R 2 1 broad Inst of MIT & Harvard, Cambridge, Usa 2 Univ Hospital of Zurich, switzerland 3 Yale Univ<br />
school of Medicine, new Haven, Usa 4 Dana-farber Cancer Inst, boston, Usa<br />
17<br />
CONCURRENT<br />
SESSIONS
CONCURRENT<br />
SESSIONS<br />
CONCURRENT SESSION V: Epidermis and Hair Structure and Function<br />
Saturday 12 September 2009, 08.45-10.15<br />
KAPOSI ROOM<br />
Chairs: Ralph Paus, Eli Sprecher<br />
Talk duration is 8 minutes plus 2 minutes questions.<br />
Oral 061 [Poster 395]<br />
The role of γ1 chain containing laminins for the formation and function of the dermo-epidermal basement<br />
membrane<br />
fleger-Weckmann a 1 , bechtel M 1 , Reibetanz M 1 , Chen Zl 2 , smyth n 3 , nischt R 1 1 Dermatology Department,<br />
Univ of Cologne, Germany 2 Rockefeller University, new York, Usa 3 school of biological science, University of<br />
southampton, UK<br />
Oral 062 [Poster 396]<br />
MicroRNAs regulation of keratinocytes differentiation during human skin embryogenesis<br />
nissan X, Denis J, saidani M, lemaitre G, Peschanski M, baldeschi C InseRM U861, evry, france<br />
Oral 063 [Poster 397]<br />
Targeted deletion of DNase1L2 leads to defective degradation of nuclear DNA in hairs and nails<br />
fischer H 1 , Jäger K 1 , Rossiter H 1 , szabo s 1 , Hermann M 2 , Tobin DJ 3 , Popescu C 4 , Wagner ef 5 , Tschachler e 1 ,<br />
eckhart l 1 1 Medical University of Vienna, Department of Dermatology, austria 2 Max f. Perutz laboratories,<br />
Vienna, austria 3 Center for skin sciences, school of life sciences, Univ of bradford, austria 4 DWI an der<br />
RWTH-aachen University, Germany 5 spanish national Cancer Centre, Madrid, spain<br />
Oral 064 [Poster 398]<br />
AKT-dependent PP2A activity is required for epidermal barrier formation during late epidermal development<br />
o’shaughnessy Rf 1 , Welti JC 2 , byrne C 2 1 UCl Institiute of Child Health, london, United Kingdom 2 Centre for<br />
Cutaneous Research, Institute of Cell and Molecular science, barts and the london, london, United Kingdom<br />
Oral 065 [Poster 332]<br />
Protein kinase C and AP-1-dependent upregulation of miR-203 is required for keratinocyte differentiation<br />
sonkoly e 1 , loriè eP 2 , Törmä H 2 , Kato M 3 , ståhle M 1 , Pivarcsi a 1 1 Molecular Derm Res Group, stockholm,<br />
sweden 2 Dept of Medical sciences, Uppsala Univ, sweden 3 Dept of exp Pathology, Univ of Tsukuba, Japan<br />
Oral 066 [Poster 333]<br />
IGFBP7, a biomarker deficient in psoriatic plaques and induced by UVB phototherapy, regulates keratinocyte<br />
proliferation, differentiation and apoptosis<br />
nousbeck J 1 , sarig o 2 , avidan n 3 , Indelman M 4 , bergman R 4 , Ramon M 4 , enk C 5 , sprecher e 6 1 Technion-<br />
Israel Institute of Technology, Tel aviv sourasky Medical Center, Haifa, Tel aviv, Israel 2 Tel aviv sourasky<br />
Medical Center, Tel aviv, Israel 3 Technion-Israel Institute of Technology, Haifa, Israel 4 Rambam Health Care<br />
Campus, Haifa, Israel 5 Hadassah Hebrew University Medical school, Jerusalem, Israel 6 Tel aviv sourasky<br />
Medical Center, Technion-Israel Institute of Technology, Tel aviv, Haifa, Israel<br />
Oral 067 [Poster 334]<br />
Identification of Spink6 - a widely-expressed and selective Kallikrein-related Peptidase Inhibitor<br />
Meyer-Hoffert U 1 , Kantyka T 2 , Hansmann b 1 , Gläser R 1 , schröder JM 1 1 Department of Dermatology, Kiel,<br />
Germany 2 Department of biochemistry, Krakow, Poland<br />
Oral 068 [Poster 335]<br />
Flaky tail mouse as a possible model of atopic dermatitis<br />
Moniaga C 1 , Chikuma M 1 , Kawasaki H 2 , nakajima s 1 , Tanizaki H 1 , egawa G 1 , Honda T 1 , amagai M 2 , Miyachi<br />
Y 1 , Kabashima K 1 1 Kyoto University Graduate school of Medicine, Japan 2 Keio University school of Medicine<br />
Tokyo, Japan<br />
Oral 069 [Poster 336]<br />
Increased murine Beta-defensin-1, -3, and -14 expression after acute and chronic skin barrier disruption is<br />
induced by cytokines and growth factors<br />
Hinrichsen K 1 , Meingassner J 2 , Harder J 1 , Proksch e 1 1 University Hospital Kiel, Kiel, Germany 2 novartis<br />
Institut for bioMedical Research, Vienna, austria<br />
18
CONCURRENT SESSION VI: Carcinogenesis and Angiogenesis<br />
Saturday 12 September 2009, 08.45-10.15<br />
GRUBY ROOM<br />
Chairs: Véronique Delmas, Reinhard Dummer<br />
Talk duration is 8 minutes plus 2 minutes questions.<br />
Oral 070 [Poster 459]<br />
Promotion of lymphatic integrity by Angiopoietin-1<br />
Kajiya K 1 , Kidoya H 2 , sawane M 1 , Yamanishi H 1 , Takakura n 2 1 shiseido Innovative science Research &<br />
Development Center, Yokohama, Japan 2 osaka University, Japan<br />
Oral 071 [Poster 460]<br />
Pregnancy promotes melanoma lymph node invasion by enhancing VEGF dependent lymphangiogenesis<br />
Khosrotehrani K 1 , nguyen Huu s 1 , Prignon a 1 , oster M 1 , avril Mf 2 , boitier f 2 , aractingi s 1 1 Pierre et Marie<br />
Curie University-Paris6, Paris, france 2 Tarnier Hospital, Paris, france<br />
Oral 072 [421]<br />
Epithelial-mesenchymal transition (EMT)-like phenotype in GnT-V transgenic<br />
Ishikawa a, Terao M, nakahara s, Kimura a, Moriwaki K, Murota H, Taniguchi n, Miyoshi e, Katayama I osaka<br />
University, suita-shi, Japan<br />
Oral 073 [Poster 422]<br />
Tumor-stroma interaction is essential in a primary human in vitro skin cancer model using a human cancerassociated<br />
dermal microenvironment<br />
Commandeur s, De Gruijl fR, Willemze R, Tensen CP, elghalbzouri a leiden University Medical Center, leiden,<br />
netherlands<br />
Oral 074 [Poster 423]<br />
MK2 regulates the early stages of skin tumor promotion<br />
Johansen C 1 , Vestergaard C 1 , Kragballe K 1 , Ronkina n 2 , bohlmann l 2 , Kollias G 3 , Gaestel M 2 , Iversen l1<br />
1 aarhus University Hospital, aarhus C, Denmark 2 Hannover Medical school, Hannover, Germany 3 biomedical<br />
sciences Research Center “alexander fleming”, Vari, Greece<br />
Oral 075 [Poster 424]<br />
RAGE signaling promotes tumor-angiogenesis and controls endothelial cell-specific immune cell recruitment<br />
Gebhardt C 1 , Kiessling f 2 , Delorme s 3 , nawroth PP 1 , bierhaus a 1 , arnold b 3 , enk aH 1 , angel P 3 1 University<br />
Hospital Heidelberg, Germany 2 University Hospital aachen, Germany 3 German Cancer Research Center (DKfZ),<br />
Heidelberg, Germany<br />
Oral 076 [Poster 425]<br />
Mice Lacking MSK1 and MSK2 Show Decreased Skin Tumor Development In a Two Stage Chemical<br />
Carcinogenesis Model<br />
Chang s 1 , Iversen l 1 , arthur Js 2 , Kragballe K 1 , Johansen C 1 1 aarhus University Hospital, aarhus C, Denmark<br />
2 University of Dundee, Dundee, United Kingdom<br />
Oral 077 [Poster 426]<br />
Quiescent cultured keratinocytes derived from squamous cell carcinoma retain a cancer-specific gene<br />
expression signature capable of differentiating squamous cell carcinoma from normal skin in vivo<br />
Pourreyron C 1 , foerster J 1 , Hogan C 1 , Purdie K 2 , bruckner-Tuderman l 3 , Proby C 1 , McGrath Ja 4 , leigh IM 1 ,<br />
south aP 1 1 University of Dundee, UK 2 Cancer Research UK, london, 3 Univ of freiburg, Germany 4 University of<br />
london, UK<br />
Oral 078 [Poster 427]<br />
Effects of the immunosuppressant rapamycin on skin carcinoma formation by chronic UV exposure<br />
Voskamp P 1 , Koehl Ge 2 , Rebel HG 1 , bouwes bavinck Jn 1 , Geissler eK 2 , De Gruijl fR 1 1 leiden University<br />
Medical Center, netherlands 2 University of Regensburg, Germany<br />
19<br />
CONCURRENT<br />
SESSIONS
CONCURRENT<br />
SESSIONS<br />
CONCURRENT SESSION VII: Cell Adhesion, Matrix Biology and Growth Factors<br />
Saturday 12 September 2009, 11.15-12.45<br />
KAPOSI ROOM<br />
Chairs: Johann Bauer, Cornelia Mauch<br />
Talk duration is 8 minutes plus 2 minutes questions.<br />
Oral 079 [Poster 472]<br />
Novel fibronectin (FN) peptide protects adult human dermal fibroblasts (AHDF) from oxidative- and cytokineinduced<br />
death and inhibits burn injury progression<br />
Clark R, Macri l, Tonnesen T stony brook University, stony brook, Usa<br />
Oral 080 [Poster 473]<br />
The role of the receptor tyrosine kinase, Axl, in intercellular adhesion and signalling in cutaneous squamous<br />
cell carcinoma<br />
Cichon Ma, Papadakis es, Mackenzie IC, o’Toole ea barts and the london sMD, Queen Mary University of<br />
london, london, United Kingdom<br />
Oral 081 [Poster 474]<br />
The mTOR inhibitor everolimus is a potent suppressor of collagen synthesis in vitro and skin and lung fibrosis<br />
in mice - perspectives for new treatments of fibrotic diseases<br />
böhm M 1 , Kokot a 1 , luger Ta 1 , scharffetter-Kochanek K 2 , sindrilaru a 2 1 University of Münster, Dept of<br />
Dermatology, Münster, Germany 2 University of Ulm, Dept of Dermatology and allergic Diseases, Ulm, Germany<br />
Oral 082 [Poster 475]<br />
Laminin-332 and perlecan are crucial regulators of the plasminogen activation cascade: implications for<br />
epithelial homeostasis and tumor formation<br />
Gagnoux-Palacios l, botta a, Delteil f, estrach s, Meneguzzi G InseRM, nice, france<br />
Oral 083 [Poster 500]<br />
Dimethylfumarate inhibits Macrophage Inhibitory Factor induced proliferation of keratinocytes<br />
Gesser b, Rasmussen MK, Rosada C, Johansen C, Kjellerup K, Kragballe K, Iversen l aarhus University<br />
Hospital, aarhus C, Denmark<br />
Oral 084 [Poster 501]<br />
STAT4 serine phosphorylation during keratinocyte mitosis<br />
ferreli C, Pickard C, august s, buggy Y, ardern-Jones M, friedmann Ps, Healy e University of southampton,<br />
southampton, United Kingdom<br />
Oral 085 [Poster 502]<br />
Regulation of tissue inhibitor of matrix metalloproteinases-1 and -3 in fibroblasts by mitogen-activated<br />
protein kinase pathways and zinc binding protein 89<br />
Hieta n 1 , ala-aho R 2 , Merchant Jl 3 , Kähäri VM 2 1 Turku University Hospital, Turku, finland 2 University of<br />
Turku, Turku, finland 3 University of Michigan, ann arbor, Usa<br />
Oral 086 [Poster 476]<br />
Collagen-binding integrins alpha2beta1 and alpha11beta1 - key determinants of scar matrix remodeling?<br />
Hallinger R 1 , blumbach K 1 , Gullberg D 2 , Krieg T 1 , eckes b 1 1 Dermatology, Univ of Cologne, Cologne, Germany<br />
2 Physiology, Univ of bergen, bergen, norway<br />
Oral 087 [Poster 477]<br />
Collagen XVII in hemidesmosomes is involved in keratinocyte-collagen IV adhesion and p38-MAPK-dependent<br />
cell migration and signaling<br />
McMillan JR 1 , Qiao H 2 , shibaki a 2 , long Ha 2 , Wang G 2 , nishie W 2 , akiyama M 2 , shimizu H 2 1 Hokkaido<br />
University, The University of Queensland, Herston, brisbane, australia 2 Hokkaido University, sapporo, Japan<br />
20
CONCURRENT SESSION VIII: Auto-Immunity, Inflammation and Infectious Diseases<br />
Saturday 12 September 2009, 11.15-12.45<br />
GRUBY ROOM<br />
Chairs: Masa Amagai, Vincent Piguet<br />
Talk duration is 8 minutes plus 2 minutes questions.<br />
523 [Oral 088]<br />
Identification of a novel skin homing Vγ9Vδ2 T cell subset and its potential implication in the<br />
immunopathogenesis of psoriasis<br />
laggner U, Di Meglio P, Hundhausen C, Perera G, smith CH, barker J, Hayday a, nestle f King’s College<br />
london, london, United Kingdom<br />
Oral 089 [Poster 524]<br />
Non-allergenic mediators from pollen induce mast cell dependent skin inflammation<br />
Metz M 1 , Gilles s 2 , Heydrich s 1 , Traidl-Hoffmann C 2 , Maurer M 1 1 Charité - Universitätsmedizin berlin, berlin,<br />
Germany 2 ZaUM-Center for allergy and environment, HelmholtzCenter/Technische Universität München,<br />
Munich, Germany<br />
Oral 090 [Poster 600]<br />
Mast cells regulate the magnitude and the cytokine microenvironment in HSV infection<br />
aoki R 1 , Kawamura T 1 , Goshima f 2 , nishiyama Y 2 , shimada s 1 1 University of Yamanashi, Yamanashi, Japan<br />
2 nagoya University Graduate school of Medicine, nagoya, Japan<br />
Oral 091 [Poster 525]<br />
Identification of a novel receptor For S100a8/A9, a key mediator of inflammation in human skin<br />
Hibino T 1 , sakaguchi M 2, ehama R 1 , Yamamoto M 3 , Motoyama n 1 1 shiseido Research Center, Yokohama,<br />
Japan 2 okayama University Graduate school of Medicine, okayama, Japan 3 Tokyo Medical University, Dept of<br />
Dermatology, Tokyo, Japan<br />
Oral 092 [Poster 526]<br />
Characterization of functions and egress mechanism on skin regulatory T cell using Kaede-transgenic mice<br />
Honda T 1 , Tomura M 2 , otsuka a 1 , Tanizaki H 1 , Kanagawa o 2 , Miyachi Y 1 , Kabashima K 1 1 Kyoto University,<br />
Kyoto, Japan 2 RIKen, Yokohama, Japan<br />
Oral 093 [Poster 527]<br />
Isolation and characterization of autoreactive human Mabs from pemphigus vulgaris patients<br />
Di Zenzo G 1 , Di lullo G 2 , Calabresi V 1 , sinistro a 1 , Didona b 3 , Cianchini G 4 , eming R 5 , Hertl M 5 , Zambruno<br />
G 1 , lanzavecchia a 2 1 Molecular and Cell biology laboratory, IDI-IRCCs, Rome, Italy 2 Inst for Research in<br />
biomedicine-IRb, bellinzona, switzerland 3 I Derm Division, IDI-IRCCs, Rome, Italy 4 V Dermatology Division,<br />
IDI-IRCCs, Rome, Italy 5 Dept of Dermatology & allergology, Philipp’s University, Marburg, Germany<br />
Oral 094 [Poster 528]<br />
Self-peptide treatment prolongs survival in murine autoimmunity via CD8/Valpha2-(co)receptor tuning and<br />
reduction of both IL2-/IL7-induced STAT5-signaling and effector cytokines<br />
Gutermuth J, nograles K, nelson e, Miyagawa f, Cho YH, Katz sI national Institutes of Health, bethesda, Usa<br />
Oral 095 [Poster 529]<br />
Association study between auto-immunity genetic markers, melanoma susceptibility and prognosis<br />
Guedj M 1 , Descamps V 2 , Dieude P 2 , Dupin n 3 , Wolkenstein P 4 , saiag P 5 , lebbe C 6 , basset-seguin n 7 ,<br />
Grandchamp b 2 , soufir n 2 1 Programme CIT 2 Hôp bichat Claude bernard 4 Hôp Tarnier 5 Hôp Henri Mondor<br />
6 Hôp ambroise Paré boulogne billancourt 7 Hôp saint louis: france<br />
Oral 096 [Poster 530]<br />
T cell labelling modalities for non invasisve in vivo T cell tracking<br />
Griessinger C, bukala D, Wiehr s, ehrlichmann s, Kehlbach R, bantleon R, Reichl G, Pichler b, Röcken M,<br />
Kneilling M eberhard Karls University, Tübingen, Germany<br />
21<br />
CONCURRENT<br />
SESSIONS
WEDNESDAY 9 SEPTEMBER 2009<br />
DAY-BY-DAY PROGRAM<br />
Time Session Room Program<br />
12.00-19.00 Registration<br />
14.00-18.00 PXe symposium nékám p 28<br />
14.00-18.00 european Immunodermatology society<br />
(eIs)<br />
14.00-18.00 european society for Pigment Cell<br />
Research (esPCR)<br />
14.00-18.00 european epidermal barrier Research<br />
network (e2bRn)<br />
14.00-19.00 Pemphigus Consensus Meeting<br />
(Invitation only)<br />
15.00-19.00 esDR board Meeting I<br />
(Invitation only)<br />
18.00- eIs board Meeting<br />
(Invitation only)<br />
22<br />
semmelweis p 29<br />
Gruby p 30<br />
Kaposi p 31<br />
VIP suite -<br />
Dermatology<br />
Dept<br />
-<br />
seminar 1 -
DAY-BY-DAY PROGRAM<br />
Time Session Room Program<br />
07.00-19.00 Registration<br />
08.00-14.00 Poster Mounting<br />
08.00-10.30 european epidermal barrier Research<br />
network (e2bRn)<br />
23<br />
Kaposi p 31<br />
08.00-10.30 neurobiology of the skin nékám p 32<br />
08.00-10.30 european society of Dermatopathology<br />
(esDP)<br />
08.00-10.30 european Dermato-epidemiology<br />
network (eDen)<br />
10.30-11.00 Coffee break<br />
Gruby p 33<br />
semmelweis p 34<br />
11.00-12.30 esDR Postgraduate Course semmelweis p 9<br />
12.30-14.00 skin Cell Migration/Invasion workshop Kaposi p 26<br />
12.30-14.00 JDs editorial board Meeting nékám<br />
13.00-14.00 biotest sponsored symposium Gruby p 36<br />
14.00-16.00 Plenary session I (8 presentations) semmelweis p 11<br />
16.00-16.30 Coffee break<br />
16.30-17.00 esDR Guest lecture - Cancer<br />
(Moshe oren)<br />
Introduced by antonio Costanzo<br />
semmelweis p 9<br />
17.00-18.30 Concurrent session I: Immunology semmelweis p 14<br />
17.00-18.30 Concurrent session II: Clinical<br />
Investigation and epidemiology<br />
17.00-18.30 Concurrent session III: Photobiology,<br />
Pigmentation and Melanoma<br />
17.00-18.30 Concurrent session IV: Genetic<br />
Disease, Gene expression and Gene<br />
Therapy<br />
Kaposi p 15<br />
Gruby p 16<br />
nékám p 17<br />
18.30-19.00 Welcome Ceremony semmelweis<br />
19.00-22.00 Welcome Reception/Poster Viewing I pp 9, 41<br />
THURSDAY 10 SEPTEMBER 2009
FRIDAY 11 SEPTEMBER 2009<br />
DAY-BY-DAY PROGRAM<br />
Time Session Room Program<br />
06.45-07.45 Run for atopic Dermatitis orczy Garden p 8<br />
07.00-08.30 International Pemphigoid Consensus<br />
meeting (invitation only)<br />
24<br />
nékám<br />
08.30-11.00 Plenary session II (10 presentations) semmelweis p 12<br />
11.00-11.30 Coffee break<br />
11.30-12.00 Merck serono lecture (Ron Germain)<br />
Introduced by alexander enk<br />
12.00-12.30 René Touraine lecture (sabine Werner)<br />
Introduced by louis Dubertret<br />
12.30-14.00 JID editorial board nékám<br />
semmelweis p 9<br />
semmelweis p 9<br />
12.30-14.00 Galderma sponsored symposium Kaposi p 37<br />
14.00-15.00 esRf scientific Review Committee<br />
(invitation only)<br />
seminar 1<br />
14.00-15.30 Poster Viewing II Poster area p 41<br />
15.30-16.00 Coffee break<br />
16.00-16.10 Presentation of esDR Honorary<br />
Memberships<br />
16.10-16.40 Rudi Cormane lecture (lars french)<br />
Introduced by Reinhard Dummer<br />
semmelweis p 44<br />
semmelweis p 9<br />
16.40-16.50 Poster Prizes semmelweis<br />
16.50-16.55 esRf new Investigator awards semmelweis<br />
16.55-17.00 JsID/esDR Collegialty awards semmelweis<br />
17.00-18.30 Plenary session III (6 presentations) semmelweis p 13<br />
18.30-19.15 esDR annual General assembly semmelweis<br />
19.30- esDR 2009 Hungarian evening orczy Garden p 8
DAY-BY-DAY PROGRAM<br />
Time Session Room Program<br />
07.45-08.45 esDR/sID/JsID liaison Committee<br />
Meeting (invitation only)<br />
08.45-10.15 Concurrent session V: epidermis and<br />
Hair structure and function<br />
08.45-10.15 Concurrent session VI: Carcniogenesis<br />
and angiogenesis<br />
25<br />
seminar 1<br />
Kaposi p 18<br />
Gruby p 19<br />
08.45-10.15 Clinical saturday I semmelweis p 9<br />
10.15-11.15 Poster Viewing III (with Poster Walks<br />
and coffee break)<br />
11.15-12.45 Concurrent session VII: Cell adhesion,<br />
Matrix biology and Growth factors<br />
11.15-12.45 Concurrent session VIII: auto-<br />
Immunity, Inflammation and Infectious<br />
Diseases<br />
p 41<br />
Kaposi p 20<br />
Gruby p 21<br />
11.15-12.45 Clinical saturday II semmelweis p 9<br />
12.45-14.15 eastern european session nékám p 35<br />
12.45-14.15 CTCl Workshop<br />
(sponsored by Cephalon)<br />
Kaposi p 27<br />
14.15-15.15 2009 esDR Meeting Digest semmelweis p 9<br />
15.15-15.30 Closing Ceremony semmelweis<br />
15.30-16.30 esDR board Meeting II<br />
(invitation only)<br />
seminar 1<br />
SATURDAY 12 SEPTEMBER 2009
SPECIAL<br />
WORKSHOPS<br />
SKIN CELL MIGRATION AND INVASION<br />
Thursday 10 September 2009, 12.30-14.00<br />
KAPOSI ROOM<br />
Chair: Véronique Delmas<br />
Program<br />
12.30-12.32 Introduction by Chair<br />
12.32-12.54 Role of E-Cadherin in normal and pathological melanocyte development<br />
Véronique Delmas (orsay, france)<br />
12.54-13.16 Regulation of Integrin-dependent cell migration by cytoplasmic adapter<br />
proteins<br />
bernhard Wehrle-Haller (Geneva, switzerland)<br />
13.16-13.38 Functions of Rac1 in epidermal wound healing and epithelial skin tumor<br />
invasion<br />
Ingo Haase (Cologne, Germany)<br />
13.38-14.00 Functions of MMPs in skin invasion process<br />
Cornelia Mauch (Cologne, Germany)<br />
This Workshop is open to all esDR meeting participants.<br />
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26
CTCL<br />
Saturday 12 September 2009, 12.45-14.15<br />
KAPOSI ROOM<br />
Chairs: Martine Bagot, Reinhard Dummer<br />
Program<br />
12.45-13.05 French Bexarotene Survey: ORELY, Baseline of 106 Patients with CTCL<br />
Christophe bedane (limoges, france)<br />
13.05-13.25 EORTC Clinical Trials: How to Create an Intelligent Platform!<br />
Martine bagot (Paris, france)<br />
13.25-13.45 Targeted Therapies in CTCL: Do They Hit the Target?<br />
Reinhard Dummer (Zurich, switzerland)<br />
13.45-14.05 Challenging Clinical Cases<br />
Marta Marschalko, budapest<br />
14.05-14.15 Round Table Discussion<br />
This Workshop is open to all esDR meeting participants.<br />
27<br />
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SPECIAL<br />
WORKSHOPS
PXE<br />
SYMPOSIUM<br />
SATELLITE <strong>MEETING</strong>: PXE SYMPOSIUM<br />
Wednesday 9 September 2009, 14.00-18.00<br />
NEKAM ROOM<br />
Sponsored by PXE International<br />
note: To partially offset the costs of this symposium, a modest fee of euro 50 is requested<br />
from those participants who are not registered for the main esDR meeting. This fee includes<br />
Hungarian wine reception at the conclusion of the symposium. This fee should be paid at the<br />
main esDR registration desk by cash or credit card.<br />
Chairs: andras Váradi, sharon Terry and Jouni Uitto<br />
Program<br />
14.00-14.30 Introduction to PXE – The Role of Patient Advocacy Organisations<br />
Patrick Terry (PXe International)<br />
14.30-15.00 Clinical and Morphological Observations in PXE<br />
Ivonne Pasquali-Ronchetti (University of Modena)<br />
15.00-15.30 The ABCC6 Transporter System - Perturbations in PXE<br />
andras Váradi (Hungarian academy of sciences)<br />
15.30-16.00 Pathomechanisms of PXE<br />
Jouni Uitto (Thomas Jefferson University)<br />
16.00-18.00 Roundtable Discussion: Prospects of Therapies for PXE<br />
Invited discussants and all participants<br />
18.00 Hungarian Wine Reception<br />
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28
SATELLITE <strong>MEETING</strong>: EUROPEAN IMMUNODERMATOLOGY SOCIETY (EIS)<br />
Wednesday 9 September 2009, 14.00-18.00<br />
SEMMELWEIS ROOM<br />
The european Immunodermatology society (eIs) meeting will be held at the esDR meeting<br />
venue and is open to all registered esDR Meeting participants.<br />
Program<br />
14.00-14.05 Welcome<br />
Richard Groves (london), Jan simon (leipzig)<br />
Session 1<br />
14.05-14.20 Abscence of CCR4 Exacerbates Skin Inflammation in the Oxazolone Induced Contact<br />
Hypersensitivity Model<br />
sari lehtimäki (Helsinki)<br />
14.20-14.35 ATP is a tissue site specific activator of the suppressive capacity of naïve regulatory T cells<br />
during contact hypersensitivity reactions<br />
sabine Ring (Heidelberg)<br />
14.35-14.50 Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis<br />
anna balato (naples)<br />
14.50-15.05 Flow cytometric analysis of peripheral invariant NKT cells in patients with atopic dermatitis<br />
edit Gyimesi (Debrecen)<br />
15.05-15.20 IL-17 and IL-22 producing Th17 cells induce protein contact dermatitis<br />
Ivana Glocova (Tübingen)<br />
15.20-15.35 Impaired allergic contact dermatitis response to DNCB in atopic dermatitis (AD) is enhanced by<br />
filaggrin loss of function variants<br />
louise newell (southampton)<br />
15.35-15.50 Induction of regulatory T cells by immature epidermal Langerhans cells upon oral<br />
glucocorticosteroid treatment<br />
Georg stary (Vienna)<br />
15.50-16.20 Coffee Break<br />
Session 2<br />
16.20-16.35 The characterisation of regulatory and effector FOXP3 expressing T cell populations during a<br />
human cutaneous antigen-specific memory response in vivo<br />
elaine agius (london)<br />
16.35-16.50 Participation of newly-identified IL-1 family members in the pathogenesis of psoriasis<br />
andrew Johnston (london)<br />
16.50-17.05 Production of Tolerance-Inducing Molecules for Type XVII Collagen for Gene Therapy in<br />
Junctional Epidermolysis Bullosa Patients<br />
Monika ettinger (salzburg)<br />
17.05-17.20 Th1/TH17 cells amplify human contact hypersensitivity by licensing Th1to kill autologous<br />
keratinocytes in a ICAM-1 dependent antigen non specific manner<br />
andrea Cavani (Rome)<br />
17.20-17.35 CGRP induces ex vivo upregulation of epidermal TLR9 expression and LL37 gene-expression<br />
ewout baerveldt (Rotterdam)<br />
17.35-17.50 The role of interleukin-1 and the interleukin-1 receptors in regulatory T cell functions<br />
ferenc Kovács-sólyom (szeged)<br />
17.50-18.00 Concluding Remarks<br />
29<br />
EIS <strong>MEETING</strong>
ESPCR<br />
SYMPOSIUM<br />
SATELLITE SYMPOSIUM: EUROPEAN SOCIETY FOR PIGMENT CELL RESEARCH (ESPCR)<br />
Wednesday 9 September 2009, 14.00-18.00<br />
GRUBY ROOM<br />
The esPCR symposium will be held at the esDR meeting venue and is open to all registered<br />
esDR Meeting participants.<br />
Program<br />
14.00-14.15 Introduction and Overall Presentation: “To Tan or not to Tan? This is the Symposium”<br />
Mauro Picardo (Rome)<br />
14.15-14.35 New Molecular Aspects in the Regulation of Skin Pigmentation<br />
Robert ballotti (nice)<br />
14.35-14.55 UVB, Tanning and Anti-oxidative Effector Mechanisms induced by alpha-melanocyte<br />
Stimulating Hormone<br />
Markus bohm (Münster)<br />
14.55-15.15 Melanin Transfer in Human Skin Cells in vitro: A Fascinating World beyond the Dendrite<br />
Des Tobin(bradford)<br />
Free Communications 1 & 2 (10 minutes + 2 minutes discussion)<br />
15.20-15.32 UVB regulation is both direct and indirect on TRP-1 mRNA, a melanocyte differentiation<br />
marker in human melanocytes<br />
bernadett Kormos (szeged)<br />
15.32-15.44 The role of Wnt/b-catenin pathway in melanocytes differentiation<br />
barbara bellei (Rome)<br />
15.44-15.55 Break<br />
15.55-16.15 Fibroblasts Regulate the Basal Pigmentation pf the Skin in vitro and in vivo<br />
Muriel Cario-andré (bordeaux)<br />
16.15-16.35 From Pigmentation to Melanoma: The Role of SOX9 in Melanocytes<br />
Thierry Passeron (nice)<br />
16.35-16.55 Albinism in Tanning<br />
lluis Montoliu (Madrid)<br />
16.55-17.15 From Proliferation to Pigmentation<br />
lionel larue (Paris)<br />
Free Communications 3-5 (10 minutes + 2 minutes discussion)<br />
17.15-17.27 What are the objective determinants of tanning (facultative pigmentation)?<br />
Terence Wong (edinburgh)<br />
17.27-17.39 An interplay between TGF-beta and PKA signaling inversely regulates the melanogenic<br />
differentiation program in melanoma cells<br />
alain Mauviel (Paris)<br />
17.39-17.51 Evaluation of Ethosomes for Delivery of siRNA into Cultured Primary Melanocytes and Skin<br />
Mireille Van Gele (Ghent)<br />
17.51-18.00 Concluding Remarks<br />
30
SATELLITE <strong>MEETING</strong>: 7TH EUROPEAN EPIDERMAL BARRIER RESEARCH NETWORK (E2BRN)<br />
9-10 September 2009<br />
KAPOSI ROOM<br />
The 7th european epidermal barrier Research network (e2bRn) meeting will be held at the<br />
esDR meeting venue and is open to all registered esDR Meeting participants.<br />
Scientific Organising Committee: PD Dr. Johanna brandner, Prof. Carien niessen, Prof. Joost<br />
schalkwijk<br />
Program<br />
Wednesday 9 September 2009<br />
Young Investigator Session (PhD/Postdocs)<br />
Chair: Michel simon (Toulouse, france)<br />
13.30-13.35 Introduction<br />
13.35-13.50 Active transdermal protein delivery through photoinduced pressure waves<br />
Gonzalo f.f. sa (Coimbra, Portugal)<br />
13.50-14.05 Comparison of Microdialysis and Microperfusion for efficient in vivo research on dermal<br />
barrier function and penetration<br />
Manfred bodenlenz (Graz, austria)<br />
14.05-14.20 Evaluation of the role of autophagy in epidermal keratinocytes<br />
Heidemarie Rossiter (Vienna, austria)<br />
14.20-14.35 Lysyl Oxidase silencing impairs keratinocyte differentiation<br />
G. le Provost (lyon, france)<br />
14.35-14.50 Coffee Break<br />
14.50-15.05 Alteration of tight junction proteins is an early event in psoriasis and involves proinflammatory<br />
cytokines<br />
nina Kirschner (Hamburg, Germany)<br />
15.05-15.20 Decreased Filaggrin expression results in impaired epidermal barrier function in ichthyosis<br />
vulgaris<br />
Robert Gruber (Innsbruck, austria)<br />
15.20-15.35 Deletion of the LCE3B and LCE3C Genes on 1q21 is not associated with atopic dermatitis<br />
Judith bergboer (nijmegen, netherlands)<br />
15.35-15.50 Lef1 mediated regulation of sebaceous gland lipid metabolism regulates skin barrier function<br />
Catherin niemann (Cologne, Germany)<br />
15.50-15.55 Concluding Remarks<br />
15.55-16.30 Coffee Break<br />
Workshop on Reconstructed Skin Models as Alternatives to Animal Experiments<br />
Chair: leopold eckhart (Vienna, austria)<br />
16.30-17.00 Barrier Properties of Human Skin Equivalents<br />
Joke bouwstra (leiden, netherlands)<br />
17.00-17.30 Use of gene silencing in reconstructed skin models<br />
Michael Mildner (Vienna, austria)<br />
17.30-18.00 In vitro reconstructed skin models: applications in epidermal biology and inflammation<br />
Joost schalkwijk (nijmegen, netherlands)<br />
Thursday 10 September 2009<br />
Senior Member Session<br />
Chair: Johanna M. brandner (Hamburg, Germany)<br />
09.00-09.30 The fate of cell-cell junctions upon cornification and their impact on desquamation<br />
Marek Haftek (lyon, france)<br />
09.30-10.00 The role of intercellular adhesion and polarity in the regulation of the skin barrier<br />
Carien niessen (Cologne, Germany)<br />
10.00-10.30 Degradation of nucleic acids at the epidermal barrier<br />
leopold eckhart (Vienna, austria)<br />
10.30-10.50 Coffee Break<br />
10.50-12.30 E2BRN General Assembly<br />
31<br />
E2BRN <strong>MEETING</strong>
NEUROBIOLOGY OF THE SKIN<br />
SYMPOSIUM<br />
SATELLITE SYMPOSIUM: NEUROBIOLOGY OF THE SKIN<br />
Thursday 10 September 2009, 08.00-10.30<br />
NEKAM ROOM<br />
The neurobiology of the skin symposium will be held at the esDR meeting venue and is open to<br />
all registered esDR Meeting participants.<br />
Chairs: anna Zalewska (lodz, Poland), Marcus Maurer (berlin, Germany)<br />
Program<br />
Neurotrophins in healthy and diseased skin<br />
C Pincelli (Modena, Italy)<br />
Skin mast cells and cutaneous sensory nerves – duo infernale of pruritus<br />
M Maurer (berlin, Germany)<br />
Neuroreceptors involved in Pruriception<br />
s ständer (Munich, Germany)<br />
Alpha-MSH and fragments: mediators of neuroinflammation with a therapeutic potential<br />
T luger (Munich, Germany)<br />
Catecholamines and stress: implications for wound healing<br />
RR Isseroff (sacremento, Usa)<br />
fMRI brain scan studies in dermatology<br />
CeM Griffiths (Manchester, UK)<br />
Psychoneuroimmunology – clinical implications<br />
W Glinski (Warsaw, Poland)<br />
ItchyQol and CuQol – Novel instruments for measuring quality of life in patients with pruritic<br />
skin disorders<br />
M Metz (berlin, Germany)<br />
noTes.............................................................................................................................................................................<br />
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32
SATELLITE SYMPOSIUM: EUROPEAN SOCIETY FOR DERMATOPATHOLOGY (ESDP)<br />
Thursday 10 September 2009, 08.00-10.30<br />
GRUBY ROOM<br />
The esDP symposium will be held at the esDR meeting venue and is open to all registered<br />
esDR Meeting participants.<br />
Chair: Gürkan Kaya (Geneva, switzerland)<br />
Program<br />
08.00-08.05 Welcome<br />
08.05-08.35 Role of calcium and NFAT signalling in sensing and responding to<br />
environmental stress in the epidermis<br />
nick Reynolds (newcastle)<br />
08.35-09.05 Regulating malignant formation by T-cell cytokines<br />
Martin Röcken (Tübingen)<br />
09.05-09.35 Translational medicine: What the pharma industry wants from the<br />
dermatopathologist<br />
Conrad Hauser (Geneva)<br />
09.35-10.05 Genomics of melanoma progression: Research without clinical<br />
application?<br />
József Tímár (budapest)<br />
10.05-10.25 Panel Discussion<br />
10.25-10.30 Concluding Remarks<br />
noTes.............................................................................................................................................................................<br />
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33<br />
ESDP<br />
SYMPOSIUM
EDEN<br />
<strong>MEETING</strong><br />
SATELLITE <strong>MEETING</strong>: EUROPEAN DERMATO-EPIDEMIOLOGY NETWORK (EDEN)<br />
Thursday 10 September 2009, 08.00-10.30<br />
SEMMELWEIS ROOM<br />
The eDen Meeting will be held at the esDR meeting venue and is open to all registered esDR<br />
Meeting participants.<br />
Chair: PJ Coenraads (Groningen, The netherlands)<br />
Program<br />
08.00-08.05 Opening<br />
PJ Coenraads (Groningen)<br />
08.05-08.20 Changing delayed-type hypersensitizations to the standard series allergens over a decade at<br />
the Zurich University Hospital<br />
M Janach (Zurich)<br />
08.20-08.35 A prospective case-controlled cohort study to assess pre-clinical cardiovascular disease in<br />
patients with moderate to severe psoriasis<br />
Cl Martyn-simmons (london)<br />
08.35-08.50 Epidemiology of cutaneous melanoma in Austria 1996, preliminary results of a national<br />
histopathology-based survey<br />
K Rappersberger (Vienna)<br />
08.50-09.05 Using a structured image database: how well can novices assign skin lesion images to the<br />
correct diagnostic grouping<br />
Jl Rees (edinburgh)<br />
09.05-09.20 Use of the Day Reconstruction Method (DRM) as an experiential sampling tool to assess<br />
subjective symptoms in atopic dermatitis<br />
Jl Rees (edinburgh)<br />
09.20-09.35 Prevalence of atopic dermatitis in urban and rural schools in Gabon and Ghana<br />
aP lavrijsen (leiden)<br />
09.35-09.50 Squamous cell carcinoma of the skin induces sustained considerable cost of care in organ<br />
transplant recipients<br />
C Rüegg (Zurich)<br />
09.50-10.05 Ethnic variations in facial variations in facial skin neurosensitivity assessed by capsaicin<br />
detection thresholds<br />
R Jourdain (Clichy)<br />
10.05-10.20 Analysis of risk factors in cutaneous malignant melanoma: an Italian population-based study<br />
e Campione (Rome)<br />
10.20-10.30 Concluding Remarks<br />
PJ Coenraads (Groningen)<br />
noTes.............................................................................................................................................................................<br />
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34
COMMON GOALS AND CHALLENGES IN DERMATOLOGIC RESEARCH IN EASTERN EUROPE<br />
Saturday 12 September 2009, 12.45-14.15<br />
NEKAM ROOM<br />
Chairs: Stephen Katz, Sarolta Kárpáti<br />
note: This session is open to all eastern european scientists and those with<br />
an interest in the development of dermatological research in eastern europe.<br />
Program<br />
12.45-12.50 Introduction<br />
12.50-13.10 Development of <strong>ESDR</strong> activities in Eastern Europe<br />
sarolta Kárpáti (Hungary)<br />
13.10-13.30 Common goals and challenges in Dermatologic Research<br />
stephen Katz (Usa)<br />
13.30-14.10 Open discussion with the participants<br />
Moderator: norbert Wikonkal<br />
14.10-14.15 Donation of the Nekam Plaquette<br />
awarded to stephen Katz by the Hungarian Dermatological<br />
society as recognition of his contribution to the development<br />
of dermatology worldwide<br />
noTes........................................................................................................................................................................<br />
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35<br />
EASTERN EUROPE<br />
SESSION
BIOTEST<br />
SYMPOSIUM<br />
INTRAVENOUS IMMUNOGLOBULINS IN DERMATOLOGICAL AUTOIMMUNE DISEASES<br />
Thursday 10 September 2009, 13.00-14.00<br />
GRUBY ROOM<br />
Chairs: Alexander Enk (Heidelberg), Lars French (Zurich)<br />
Program<br />
European Guidelines on the use of High-Dose IVIG in Dermatology:<br />
Indications and Therapy Management<br />
alexander enk (Heidelberg)<br />
IVIG 2009: Mechanisms of Action and their Role in the Treatment of<br />
Autoimmune Diseases<br />
beatrix Volc-Platzer (Vienna)<br />
Toxic Epidermal Necrolysis: Current Understanding and Therapeutic<br />
Possibilities<br />
lars french (Zurich)<br />
NOTES<br />
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .<br />
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .<br />
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .<br />
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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .<br />
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .<br />
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36
ADVANCES IN ROSACEA RESEARCH<br />
Friday 11 September 2009, 12.30-14.00<br />
KAPOSI ROOM<br />
Note: Lunch boxes will be provided to symposium participants.<br />
Introduction<br />
Rosacea is one of the most frequent diagnoses in dermatology. first, this chronic inflammatory skin disease clearly<br />
has a genetic component which is of unknown origin as of yet. additionally, rosacea can be triggered by many<br />
external/environmental factors such as ultraviolet radiation, spicy food, alcohol, stress, temperature changes<br />
etc. It is interesting to note that - being a progressive chronic inflammatory skin disease - the development of<br />
rosacea is characterized by multiple clinical conditions such as transient or persistent erythema, telangiectasia,<br />
lymphedema and later fibrosis. Morphologically, rosacea is characterized by a lympho-monocytic infiltrate.<br />
However, activated keratinocytes, fibroblasts and mast cell suggest that the pathophysiology of this disease is<br />
very complex, and involves almost all skin and immune cells. That being said, rosacea appears to be also a very<br />
good “model” for learning more about the complexity of neuro-immune interactions, dysregulated inflammatory<br />
mechanisms and immunity, as well as vascular dysregulation during inflammation, and the development of<br />
fibrotic processes during chronic inflammation.<br />
Indeed, evidence is evolving that in chronic inflammatory diseases a close molecular and cellular interaction<br />
exists between innate immune defence mechanisms, nerves, immune as well as blood and lymphatic endothelial<br />
cells. It is important to highlight, that the treatment of this common disease is still unsatisfactory and which<br />
demands a deeper understanding of the underlying mechanisms. Consequently, this symposium will focus<br />
on understanding the molecular clusters of different body systems (immune, nervous, vascular, connective)<br />
during chronic inflammatory processes, in order to find new strategies for the treatment of rosacea and other<br />
inflammatory or fibrotic skin diseases.<br />
Program<br />
Introduction<br />
Martin steinhoff (Germany/Usa)<br />
Clinical Update on Rosacea<br />
Martin schaller (Germany)<br />
Innate Immune System in Rosacea<br />
Jürgen schauber (Germany)<br />
Role of the Vascular Symstem in Inflammatory Skin Diseases<br />
Michael Detmar (switzerland)<br />
Role and Mechanisms of Action of Activin in Wound Repair, Fibrosis and Skin Cancer<br />
sabine Werner (switzerland)<br />
Neuroimmunological Aspects of Rosacea<br />
Martin steinhoff (Germany/Usa)<br />
Questions & Answers/Closing Remarks<br />
Martin steinhoff (Germany/Usa)<br />
NOTES<br />
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37<br />
GALDERMA<br />
SYMPOSIUM
GENERAL<br />
INFORMATION<br />
GENERAL INFORMATION<br />
THE <strong>MEETING</strong> VENUE<br />
The 39th esDR annual Meeting is held from Wednesday 9 september to saturday 12 september 2009 at the<br />
semmelweis University - soTe net, in budapest, Hungary. The University is located a few kilometres outside the<br />
city centre and is easily accessible by public transport.<br />
Address of Meeting Venue<br />
semmelweis University - soTe net<br />
nagyvárad tér 4<br />
H-1089 budapest<br />
Hungary<br />
Getting to Semmelweis University - SOTE Net<br />
The easiest way to get to the venue is by metro. Take the blue line (line 3) to the nagyvárad tér stop. When you<br />
exit, you will see a tall building (semmelwies Medical University building). Walk towards this building. The esDR<br />
meeting is located in the lecture complex adjacent to this building. Metro tickets are available for sale at the<br />
meeting venue.<br />
OFFICIAL LANGUAGE<br />
The official language of the Meeting is english. no simultaneous translation is provided.<br />
<strong>MEETING</strong> OFFICE<br />
During the Meeting<br />
The secretariat of the Meeting (Registration Desk, Meeting office) is located in the main lecture hall complex.<br />
Before and After the Meeting<br />
esDR<br />
Rue Cingria 7<br />
CH-1205 Geneva<br />
switzerland<br />
Tel: +41 22 321 48 90<br />
fax: +41 22 321 48 92<br />
email: office@esdr.org<br />
Web: www.esdr.org<br />
Information/Registration Desk<br />
all participants must be registered. admission to scientific sessions, technical exhibition, Welcome Reception and<br />
Gala evening is by badge only.<br />
Opening Hours<br />
Wednesday 9 september 12.00-17.00<br />
Thursday 10 september 08.00-19.00<br />
friday 11 september 08.00-18.30<br />
saturday 12 september 08.00-15.00<br />
38
GENERAL INFORMATION<br />
Abstracts<br />
all posters and oral presentations are in english. The abstract book is in the delegate bags.<br />
Badges<br />
a name badge is provided with your registration documents on site. for security and regulation purposes, the<br />
wearing of this badge is compulsory at all times both inside the meeting venue and at all official events organised<br />
within the context of the meeting.<br />
Breaks and Lunches<br />
Morning and afternoon coffee breaks are included in the registration fees. five coffee tickets will be given per<br />
participant and can be used at any point during the meeting.<br />
lunches are not included in the registration fees. The University restaurant on-site will be open. a list of other<br />
restaurants nearby is available at the Registration Desk.<br />
Certificates of Attendance<br />
Certificates of attendance for pre-registered participants are issued along with the Meeting documentation upon<br />
arrival. Participants who register on-site can request this certificate at the registration desk.<br />
City Map<br />
a city map is provided in the delegate bag.<br />
Cloakroom<br />
a cloakroom is located near the Registration Desk. Please make sure that no personal belongings are left after<br />
closing each day. opening hours are the same as the Meeting ones.<br />
Continuing Medical Education<br />
acceditation statement (eaCCMe-02701-G)<br />
The european society for Dermatological Research is accredited by the european accreditation Council for<br />
Continuing Medical education (eaCCMe) to provide the following CMe activity for medical specialists. The<br />
eaCCMe is an institution of the european Union of Medical specialists (UeMs):<br />
The "39th annual esDR Meeting" is designated for a maximum of (or "for up to") 18 hours of european external<br />
CMe credits. each medical specialist should claim only those hours of credit that he/she actually spent in the<br />
educational activity.<br />
eaCCMe credits are recognized by the american Medical association towards the Physician's Recognition award<br />
(PRa). To convert eaCCMe credit to aMa PRa category 1 credit, contact the aMa.<br />
CMe certificates can be obtained from the Registration Desk on demand.<br />
Duplication, Recording, Photos<br />
Photography, audio-taping, video-recording, or any other form of duplication is strictly prohibited in the session<br />
rooms and poster areas. In the exhibition area, pictures or film are allowed only if permitted by the concerned<br />
exhibitor. failure to comply with this rule could lead to your meeting credentials being removed.<br />
First Aid<br />
for assistance, please contact any of the staff members.<br />
Insurance and Liability<br />
The organisers will accept no liability for personal injuries sustained by or for loss or damage to property<br />
belonging to Meeting participants, either during or as a result of the Meeting or during all tours and events.<br />
Internet<br />
a free wireless (wi-fi) connection is available at the meeting venue for participants with their own portable<br />
computers. an Internet corner with fixed PCs has also been set up. Please ask the Registration Desk for more<br />
information.<br />
Lost and Found<br />
lost items should be returned to the Meeting Welcome Desk. should you lose anything, please report to this desk<br />
for assistance.<br />
Membership<br />
If you wish to apply for membership of the esDR, forms are available at the Registration Desk. for membership<br />
enquiries after the meeting, please contact the esDR: office@esdr.org<br />
Mobile Phones<br />
Delegates are kindly requested to turn off their mobile phones when entering the meeting rooms and in the poster<br />
areas.<br />
39<br />
GENERAL<br />
INFORMATION
2009 MAP OF EXHIBITORS - GROUND FLOOR LEVEL<br />
1<br />
Entrance to Semmelweis<br />
& Nekam Rooms and the<br />
Gallery Level<br />
CLOAKROOM<br />
REGISTRATION<br />
1. biotest aG<br />
2. esDR 2010<br />
3. TissueGnostics GmbH<br />
4. Promocell<br />
2 3 4 5 6<br />
MAIN ENTRANCE<br />
5. Cellsystems® biotechnologie Vertrieb GmbH<br />
6. straticell<br />
7. nature Publishing Group<br />
8. CellnTeC advanced Cell systems, aG<br />
7<br />
8<br />
Steps to Gruby & Kaposi<br />
Rooms, Seminar Rooms<br />
Slide Preview and Posters
POSTER INFORMATION<br />
Installation and Removal<br />
Please remember:<br />
• Your poster must remain on display for the entire duration of the main <strong>ESDR</strong> Meeting (Thursday-Saturday).<br />
• Posters must be installed on: Thursday 10 September (poster areas open at 8.00).<br />
• Posters must be removed on Saturday 12 September between 14.00 and 15.30 at the latest.<br />
note that posters remaining in the poster exhibition areas after 15.30 on saturday 12 september will be removed<br />
and destroyed.<br />
Poster Sessions<br />
Three Poster sessions are scheduled:<br />
• POSTER SESSION I (two x 60 minute sessions) Thursday 10 September, 19.30 to 21.30<br />
even numbered Posters: authors stand by your posters from 19.30-20.30<br />
odd numbered Posters: authors stand by your posters from 20.30-21.30<br />
This session takes place during the Welcome Reception. buffet tables will be sent up close to poster areas.<br />
• POSTER SESSION II (two x 45 minute sessions) Friday 11 September, 14.00 to 15.30<br />
odd numbered Posters: authors stand by your posters from 14.00-14.45<br />
even numbered Posters: authors stand by your posters from 14.45-15.30<br />
• POSTER SESSION III (one-hour session) Saturday 12 September, 10.15-11.15<br />
all poster presenters to be in front of posters, except those joining poster walks (see below). Coffee will be<br />
available during this session.<br />
authors are requested to be near their posters during these sessions in order to be able to answer any questions<br />
and discuss their work with the participants.<br />
Poster Prizes<br />
several poster prizes will be awarded at the 2009 esDR Meeting. The awards will be made at a special ceremony<br />
on friday 11 september from 16.40-16.50 in the semmelweis Room.<br />
Poster Walks<br />
The purpose of poster walks is to encourage interaction between junior and senior researchers and to promote<br />
discussion on work presented at the meeting as posters.<br />
Poster walks take place from 10.15-11.15 on saturday 12 september during Poster session III. If you wish to join<br />
a poster walk simply meet at the meeting registration desk at this time. a list of poster walk leaders and topics<br />
will be made known at the meeting. Confirmed walk leaders at the time of publication of this program are:<br />
Tilo biedermann Immunology & auto-Immunity and Inflammation<br />
antonio Costanzo Genetic Disease, Gene expression and Gene Therapy<br />
David Kelsel Cell adhesion/Matrix biology & Growth factors and signal Transduction<br />
luis santamaria-babi Pharma track poster walk<br />
Richard Weller angiogenesis and Vascular biology<br />
norbert Wikonkal Clinical Trials & Clinical Research and Therapeutics<br />
Peter Wolf Photobiology & Pigmentation and Melanoma & Carcinogenesis<br />
Posters that have been selected for discussion will have a sticker placed on the poster board. If your poster is<br />
selected for a poster walk, please feel free to join the relevant walking tour group.<br />
SLIDE PREVIEW ROOM<br />
The slide preview room is located on the first floor.<br />
after completing meeting registration at the Registration Desk, each speaker should go to the slide preview room.<br />
The preview room will be open from 12.00 on Wednesday 9 september until the close of the Meeting.<br />
all presentations must be in english. each speaker should also verify in the final program that the name of the<br />
room and the time of the session have not changed. each meeting room is equipped with a single video-projector<br />
(lCD for computer assisted presentations, ie, Powerpoint). speakers are reminded that they may noT connect<br />
their own laptop to the lCD projector in the meeting rooms.<br />
41<br />
POSTER<br />
INFORMATION<br />
SLIDE<br />
PREVIEW
ABOUT<br />
THE <strong>ESDR</strong><br />
CURRENT <strong>ESDR</strong> EXECUTIVE COMMITTEE AND BOARD<br />
Executive Committee<br />
President<br />
Reinhard Dummer, Zurich<br />
President Elect (2009/2010)<br />
eugene Healy, southampton<br />
Immediate Past President<br />
John McGrath, london<br />
Secretary-Treasurer (2007-2010)<br />
Vincent Piguet, Geneva<br />
Assistant Secretary-Treasurer<br />
alexander enk, Heidelberg<br />
PAST OFFICERS OF THE <strong>ESDR</strong> BOARD<br />
42<br />
Board<br />
antonio Costanzo, Rome<br />
Robert Gniadecki, Copenhagen<br />
sarolta Kárpáti, budapest<br />
alain Mauviel, Paris<br />
Philippe Musette, Rouen<br />
Carien niessen, Cologne<br />
nick Reynolds, newcastle<br />
Ulpu saarialho-Kere, Helsinki<br />
luis santamaria, barcelona<br />
Peter steijlen, Maastrict<br />
Peter Wolf, Graz<br />
Year President Secretary Treasurer<br />
1971 f. serri M. Prunieras R. Cormane<br />
1972 o. braun-falco M. Prunieras R. Cormane<br />
1973 s. shuster M. Prunieras R. Cormane<br />
1974 H. Rorsman M. Prunieras R. Cormane<br />
1975 R. Cormane C. lapière e. Christophers<br />
1976 K. Wolff C. lapière e. Christophers<br />
1977 e. Jung C. lapière e. Christophers<br />
1978 e. Christophers M. Greaves T. van Joost<br />
1979 R. Marks M. Greaves W. van Vloten<br />
1980 H. schaefer M. Greaves W. van Vloten<br />
1981 e. frenk M. Greaves W. van Vloten<br />
1982 M. Greaves H. Hönigsmann W. van Vloten<br />
1983 G. Plewig H. Hönigsmann W. van Vloten<br />
1984 W. van Vloten H. Hönigsmann b. Vermeer<br />
1985 a. Giannetti W.J. Cunliffe b. Vermeer<br />
1986 J.H. saurat W.J. Cunliffe b. Vermeer<br />
1987 P. fritsch W.J. Cunliffe b. Vermeer<br />
1988 W.J. Cunliffe G.l. Vejlsgaard R. Willemze<br />
1989 b. Vermeer G.l. Vejlsgaard R. Willemze<br />
1990 J. Ring G.l. Vejlsgaard R. Willemze<br />
1991 G.l. Vejlsgaard P.s. friedmann R. Willemze<br />
1992 D.M. MacDonald P.s. friedmann R. Willemze<br />
1993 G. stingl P.s. friedmann R. Willemze<br />
1994 P.s. friedmann W. sterry P. van de Kerkhof<br />
1995 T. Krieg W. sterry P. van de Kerkhof<br />
Year President Secretary-Treasurer<br />
1996 W. sterry P. van de Kerkhof<br />
1997 K. Thestrup-Pedersen P. van de Kerkhof<br />
1998 R. Camp P. van de Kerkhof<br />
1999 P. van de Kerkhof l. bruckner-Tuderman<br />
2000 I. leigh l. bruckner-Tuderman<br />
2001 G. Zambruno l. bruckner-Tuderman<br />
2002 l. bruckner-Tuderman l. french<br />
2003 J. Rees l. french<br />
2004 M. Röcken l. french<br />
2005 l. french M. Röcken<br />
2006 T. schwarz M. Röcken<br />
2007 C. Pincelli M. Röcken<br />
2008 J. McGrath V. Piguet
<strong>ESDR</strong> COMMITTEES<br />
PHaRMa RelaTIons CoMMITTee<br />
Philippe Musette (Chair)<br />
Tilo biedermann<br />
alexander enk<br />
Robert Gniadecki<br />
Chris Griffiths<br />
eugene Healy<br />
eugene o'Keefe<br />
anthony Quinn<br />
nick Reynolds<br />
luis santamaria<br />
braham shroot<br />
MeMbeRsHIP CoMMITTee<br />
Peter steijlen (Chair)<br />
Carien niessen<br />
Johann bauer<br />
luis santamaria<br />
PATRON MEMBERS OF THE <strong>ESDR</strong><br />
The esDR acknowledges the ongoing support from its Patron Members. Patron memberships help support<br />
esDR members from eastern europe, the development of the JID and annual meeting-related projects.<br />
Martine bagot<br />
Paul R bergstresser<br />
luca borradori<br />
leena bruckner-Tuderman<br />
anthony Chu<br />
louis Dubertret<br />
andrew Y finlay<br />
lars e french<br />
Peter s friedmann<br />
alberto Giannetti<br />
Giammaria Giuliani<br />
Christopher eM Griffiths<br />
Marcel f Jonkman<br />
Veli-Matti Kähäri<br />
Roland Kaufmann<br />
Irene leigh<br />
Monika lusky<br />
Cornelia Mauch<br />
ABSTRACT REVIEWERS 2009<br />
Daniel aberdam<br />
françois aubin<br />
Monique aumailley<br />
Hervé bachelez<br />
Martine bagot<br />
Jens-Malte baron<br />
Johann bauer<br />
Mark berneburg<br />
Tilo biedermann<br />
Markus böhm<br />
anja bosserhoff<br />
Jan-nico bouwes bavinck<br />
Paul bowden<br />
Marijke Canninga-van Dijk<br />
andrea Cavani<br />
Pieter-Jan Coenraads<br />
antonio Costanzo<br />
frank de Gruijl<br />
Robert Dellavalle<br />
Michael Detmar<br />
Thomas Diepgen<br />
beate eckes<br />
alexander enk<br />
Jorge frank<br />
Marjan Garmyn<br />
neil Gibbs<br />
Jens Gille<br />
Robert Gniadecki<br />
nelleke Gruis<br />
luisa Guerrini<br />
Marek Haftek<br />
Christina Has<br />
Ulrich Hengge<br />
bernhard Homey<br />
Delphine Javelaud<br />
Marcel Jonkman<br />
Veli-Matti Kähäri<br />
sarolta Kárpáti<br />
Jorma Keski-oja<br />
Reinhard Kirnbauer<br />
Maranke Koster<br />
Cezary Kowalewski<br />
Peter Kurschat<br />
Charlie lambert<br />
bernhard lange-asschenfeldt<br />
lionel larue<br />
omar lupi<br />
Thierry Magnaldo<br />
alain Mauviel<br />
John McGrath<br />
James McMillan<br />
Martin Mempel<br />
43<br />
sCIenTIfIC PRoGRaM CoMMITTee<br />
eugene Healy (Chair)<br />
Tilo biedermann<br />
antonio Costanzo<br />
alexander enk<br />
Carien niessen<br />
Vincent Piguet<br />
nick Reynolds<br />
Peter steijlen<br />
easTeRn eURoPean CoMMITTee<br />
sarolta Kárpáti (Chair)<br />
Johann bauer (austria)<br />
norbert Wikonkál (Hungary)<br />
Cezary Kowalewski (Poland)<br />
anna Zalewska (Poland)<br />
alla Kyagova (Russia)<br />
Michael Meurer<br />
Colin s Munro<br />
Dedee f Murrell<br />
filippa nyberg<br />
Gerd Plewig<br />
Jonathan l Rees<br />
Timo Reunala<br />
lesley e Rhodes<br />
Johannes Ring<br />
Martin Röcken<br />
Jean-Hilaire saurat<br />
Thomas schwarz<br />
Guy bruno serre<br />
Georg stingl<br />
erwin Tschachler<br />
anders Vahlquist<br />
Peter CM van de Kerkhof<br />
The esDR acknowledges the contributions of the following 2009 esDR abstract reviewers:<br />
Dieter Metze<br />
laurence Michel<br />
Maya Mockenhaupt<br />
Maria Morasso<br />
Colin Munro<br />
Philippe Musette<br />
luigi naldi<br />
Joanna narbutt<br />
Graham neill<br />
Carien niessen<br />
Teresa odorisio<br />
Vincent Piguet<br />
ehrhardt Proksch<br />
nick Reynolds<br />
Thomas Ruenger<br />
Rudolph Rupec<br />
Ulpu saarialho-Kere<br />
Kerstin steinbrink<br />
Rick sturm<br />
Cord sunderkötter<br />
Rolf-Markus szeimies<br />
Des Tobin<br />
Heiko Traupe<br />
franz Trautinger<br />
erwin Tschachler<br />
Mirjana Urosevic<br />
Peter van der Kerkhof<br />
Maurice van steensel<br />
Thomas Volz<br />
stefan Weidinger<br />
norbert Wikonkal<br />
Hywell Williams<br />
Pierre Wolkenstein<br />
antony Young<br />
Helen Young<br />
Thomas Zollner<br />
ABOUT<br />
THE <strong>ESDR</strong><br />
ABSTRACT<br />
REVIEWERS
AWARDS<br />
FUTURE<br />
<strong>ESDR</strong> <strong>MEETING</strong>S<br />
<strong>ESDR</strong> AWARDS AND <strong>ESDR</strong> HONORARY MEMBERSHIPS<br />
Year <strong>ESDR</strong> Awards <strong>ESDR</strong> Honorary Members<br />
2009 ervin epstein (Usa)<br />
Peter friedmann (UK)<br />
2008 Kristian Thestrup-Pedersen (Denmark)<br />
William Cunliffe (UK)<br />
2007 Thomas Krieg (Germany)<br />
John stanley (Usa)<br />
2006 Rona MacKie (UK)<br />
Rein Willemze (netherlands)<br />
2003 Georg stingl (austria)<br />
Jouni Uitto (Usa)<br />
2000 J.P. ortonne (france) M. Greaves (UK)<br />
J-H. saurat (switzerland) e. Macher (Germany)<br />
1999 s. Jablonska (Poland)<br />
H. Ueki (Japan)<br />
1998 T. nishikawa (Japan)<br />
J. Voorhees (Usa)<br />
1997 l. Juhlin (sweden)<br />
1996 o. braun-falco (Germany) W. van Vloten (netherlands)<br />
J. Thivolet (france) e. Christophers (Germany)<br />
a. Giannetti (Italy) s. Katz (Usa)<br />
D. McDonald (UK) s. Imamura (Japan)<br />
Previously Awarded f. serri (Italy), M. Prunieras (france)<br />
o. braun-falco (Germany), R. Cormane (netherlands)<br />
R. brun (switzerland), a. Kint (belgium)<br />
Ch. lapière (belgium), K. Mustakallio (finland)<br />
H. Rorsman (sweden), s. shuster (UK)<br />
K. Wolff (austria)<br />
FUTURE <strong>ESDR</strong> <strong>MEETING</strong>S<br />
2010 40th Annual <strong>ESDR</strong> Meeting<br />
Helsinki, finland<br />
8-11 september 2010<br />
2011 41st Annual <strong>ESDR</strong> Meeting<br />
barcelona, spain<br />
7-10 september 2011<br />
2012 42nd Annual <strong>ESDR</strong> Meeting<br />
Venice, Italy<br />
19-22 september 2012<br />
2013 International Investigative Dermatology (IID)<br />
edinburgh, scotland<br />
8-11 May 2013<br />
44
<strong>ESDR</strong> MEMBERSHIP FORM<br />
Application for Membership of the <strong>ESDR</strong><br />
For further information regarding membership of the <strong>ESDR</strong> please visit our website (www.esdr.org)<br />
Name of applicant ___________________________________________________________________________________<br />
Department _________________________________________________________________________________________<br />
Institution ___________________________________________________________________________________________<br />
Full postal address ____________________________________________________________________________________<br />
Phone __________________________ Fax ___________________________ Email ___________________________<br />
AREAS OF RESEARCH ACTIVITY ____________________________________________________________________________<br />
Signature ________________________________________ Date ________________________________________________<br />
THIS APPLICATION IS SUPPORTED BY TWO CURRENT MEMBERS OF THE <strong>ESDR</strong><br />
Supporter 1 Supporter 2<br />
Name ___________________________________________ Name ____________________________________________<br />
Email ___________________________________________ Email ____________________________________________<br />
PLEASE INDICATE IF YOU ARE A MEMBER OF<br />
The Society for Investigative Dermatology (SID)*<br />
The Japanese Society for Investigative Dermatology (JSID) *<br />
MEMBERSHIP FEES<br />
Standard Membership EUR 115<br />
Patron Membership EUR 230<br />
Joint Membership for SID/JSID Members EUR 60*<br />
Membership fee Eastern European Members EUR 60<br />
Resident/Student Membership EUR 60<br />
* Fully paid-up members of the SID/JSID are eligible for a reduced <strong>ESDR</strong> (Joint) Membership fee of EUR 60.<br />
This only applies to those SID/JSID members who reside OUTSIDE Europe.<br />
RETURN THE COMPLETED FORM TO THE <strong>ESDR</strong> OFFICE OR <strong>MEETING</strong> REGISTRATION DESK<br />
European Society for Dermatological Research<br />
Rue Cingria 7, 1205 Geneva, Switzerland<br />
Telephone: +41 22 321 48 90, Fax: +41 22 321 48 92<br />
Email: office@esdr.org<br />
After verifying your application, you will receive an invoice for your membership fee.<br />
45
SUPPORTED BY<br />
http://www.euroskinresearch.org<br />
2009 ESRF New Investigator Awards<br />
The ESRF Scientific Committee and Board of Trustees are pleased to announce the<br />
recipients of 2009 ESRF New Investigator Awards.<br />
Carrie Ambler (United Kingdom)<br />
Project Title: Epidermal Notch signalling, adult hair follicle patterning, and<br />
inflammatory cell recruitment<br />
Eugene de Zwart-Storm (The Netherlands)<br />
Project Title: PPK-deafness syndromes caused by connexin26 mutations are folding<br />
diseases<br />
Claus Johansen (Denmark)<br />
Project Title: Inflammation and its role in the development of non-melanoma skin<br />
cancer<br />
Andor Pivarcsi (Sweden)<br />
Project Title: Investigation of the role of non-coding RNAs in non-melanoma skin<br />
cancers<br />
The committee and trustees thank all applicants for their submissions and congratulates<br />
the award winners. The next round of award applications will be announced on the<br />
Foundation’s website in the near future.<br />
European Skin Research Foundation<br />
7 rue Cingria, CH-1205 Geneva<br />
Switzerland<br />
Tel: +41 22 321 48 90 Fax: +41 22 321 48 92<br />
office@euroskinresearch.org http://www.euroskinresearch.org
CE.R.I.E.S.<br />
RESEARCH AWARD<br />
The Epidermal and Sensory Research and Investigation Centre (Centre de Recherches et<br />
Investigations Épidermiques et Sensorielles) CE.R.I.E.S. is the healthy skin research centre of<br />
CHANEL, whose mission is to perform and encourage research of the physiology and biology<br />
of healthy skin. In addition to conducting its own independent research, the CE.R.I.E.S. is funding<br />
an annual award.<br />
The CE.R.I.E.S. Research Award of 40,000 € is intended to honour a scientific researcher with a<br />
proven track record in fundamental or clinical research work, for a one year period, on the subject of:<br />
PHYSIOLOGY OR BIOLOGY OF HEALTHY<br />
SKIN AND/OR ITS REACTIONS<br />
TO ENVIRONMENTAL FACTORS<br />
The awardee will be selected by an international jury consisting of the members of the Scientific<br />
Advisory Board of the CE.R.I.E.S.<br />
Previous CE.R.I.E.S. Research Award Winners:<br />
CALL FOR APPLICATIONS<br />
2009 Sabine Werner, Ph.D., Zurich, Switzerland:<br />
for “Role of the cellular antioxydant glutathione in the cutaneous<br />
UV response, in wound repair and in skin carcinogenesis”.<br />
2008 Paul A. Khavari, M.D., Ph.D., Stanford, USA<br />
2007 Richard L. Gallo, M.D., Ph.D., San Diego, USA<br />
2006 Irwin Mc Lean, Ph.D., DSc, FRSE, Dundee, Scotland, UK<br />
2005 Masayuki Amagaï, M.D., Ph.D. Tokyo, Japan<br />
2004 Thomas Schwarz, M.D. Kiel, Germany<br />
2003 Angela M. Christiano, Ph.D., New York, USA<br />
2002 Dennis R. Roop, Ph.D., Houston, USA<br />
2001 Fiona M. Watt, D. Phil., London, UK<br />
2000 Michael Karin, Ph.D., San Diego, USA<br />
1999 Jonathan Rees, M.D., Edinburgh, UK<br />
1998 Jean Krutmann, M.D., Düsseldorf, Germany<br />
1997 Jens-Michael Schröder, Ph.D., Kiel, Germany<br />
1996 Akira Takashima, M.D., Ph.D., Texas, USA<br />
Requests for application forms must be addressed to:<br />
CE.R.I.E.S. Research Award<br />
20, rue Victor Noir - 92521 NEUILLY-SUR-SEINE CEDEX - FRANCE<br />
Tél. : 01 58 37 49 00 - Fax : 01 47 47 70 02<br />
www.ceries.com