Target Discovery and Validation Reviews and Protocols

86 Beaty et al.
3. Kern, S. E., Hruban, R. H., Hidalgo, M., and Yeo, C. J. (2002) An introduction to
pancreatic adenocarcinoma genetics, pathology and therapy. Cancer Biol. Ther. 1,
607–613.
4. Louvet, C., Andre, T., Lledo, G., et al. (2002) Gemcitabine combined with oxaliplatin
in advanced pancreatic adenocarcinoma: final results of a GERCOR
multicenter phase II study. J. Clin. Oncol. 20, 1512–1518.
5. Hruban, R. H., Iacobuzio-Donahue, C., Wilentz, R. E., Goggins, M., and Kern, S. E.
(2001) Molecular pathology of pancreatic cancer. Cancer J. 7, 251–258.
6. Li, D., Xie, K., Wolff, R., and Abbruzzese, J. L. (2004) Pancreatic cancer. Lancet
363, 1049–1057.
7. Goggins, M., Hruban, R. H., and Kern, S. E. (2000) BRCA2 is inactivated late in
the development of pancreatic intraepithelial neoplasia: evidence and implications.
Am. J. Pathol. 156, 1767–1771.
8. Day, J. D., Digiuseppe, J. A., Yeo, C., et al. (1996) Immunohistochemical evaluation
of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic
intraepithelial neoplasms. Hum. Pathol. 27, 119–124.
9. Caldas, C., Hahn, S. A., da Costa, L. T., et al. (1994) Frequent somatic mutations
and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma.
Nat. Genet. 8, 27–32.
10. Hahn, S. A., Schutte, M., Hoque, A. T., et al. (1996) DPC4, a candidate tumor suppressor
gene at human chromosome 18q21.1. Science 271, 350–353.
11. Schutte, M., Hruban, R. H., Geradts, J., et al. (1997) Abrogation of the Rb/p16
tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res.
57, 3126–3130.
12. Berman, D. M., Karhadkar, S. S., Maitra, A., et al. (2003) Widespread requirement
for Hedgehog ligand stimulation in growth of digestive tract tumours.
Nature 425, 846–851.
13. Miyamoto, Y., Maitra, A., Ghosh, B., et al. (2003) Notch mediates TGF alphainduced
changes in epithelial differentiation during pancreatic tumorigenesis.
Cancer Cell 3, 565–576.
14. Iacobuzio-Donahue, C. A., Maitra, A., Shen-Ong, G. L., et al. (2002) Discovery
of novel tumor markers of pancreatic cancer using global gene expression technology.
Am. J. Pathol. 160, 1239–1249.
15. Iacobuzio-Donahue, C. A., Maitra, A., Olsen, M., et al. (2003) Exploration of
global gene expression patterns in pancreatic adenocarcinoma using cDNA
microarrays. Am. J. Pathol. 162, 1151–1162.
16. Iacobuzio-Donahue, C. A., Ashfaq, R., Maitra, A., et al. (2003) Highly expressed
genes in pancreatic ductal adenocarcinomas: a comprehensive characterization
and comparison of the transcription profiles obtained from three major technologies.
Cancer Res. 63, 8614–8622.
17. Gronborg, M., Bunkenborg, J., Kristiansen, T. Z., et al. (2004) Comprehensive
proteomic analysis of human pancreatic juice. J. Proteome Res. 3, 1042–1055.
18. Ryu, B., Jones, J., Blades, N. J., et al. (2002) Relationships and differentially
expressed genes among pancreatic cancers examined by large-scale serial analysis
of gene expression. Cancer Res. 62, 819–826.