Target Discovery and Validation Reviews and Protocols
Target Discovery and Validation Reviews and Protocols
Target Discovery and Validation Reviews and Protocols
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Keratin Transgenics <strong>and</strong> Knockouts 249<br />
85. Arin, M. J., Longley, M. A., Wang, X. J., <strong>and</strong> Roop, D. R. (2001) Focal activation<br />
of a mutant allele defines the role of stem cells in mosaic skin disorders. J. Cell<br />
Biol. 152, 645–649.<br />
86. Steinert, P. M. <strong>and</strong> Marekov, L. N. (1999) Initiation of assembly of the cell envelope<br />
barrier structure of stratified squamous epithelia. Mol. Biol. Cell 10, 4247–4261.<br />
87. Akiyama, M., Takizawa, Y., Sawamura, D., Matsuo, I., <strong>and</strong> Shimizu, H. (2003)<br />
Disruption of the suprabasal keratin network by mutation M150T in the helix initiation<br />
motif of keratin 10 does not affect cornified cell envelope formation in<br />
human epidermis. Exp. Dermatol. 12, 638–645.<br />
88. Sprecher, E., Ishida-Yamamoto, A., Becker, O. M., et al. (2001) Evidence for<br />
novel functions of the keratin tail emerging from a mutation causing ichthyosis<br />
hystrix. J. Invest. Dermatol. 116, 511–519.<br />
89. Sprecher, E., Yosipovitch, G., Bergman, R., et al. (2003) Epidermolytic hyperkeratosis<br />
<strong>and</strong> epidermolysis bullosa simplex caused by frameshift mutations altering<br />
the v2 tail domains of keratin 1 <strong>and</strong> keratin 5. J. Invest. Dermatol. 120, 623–626.<br />
90. Kalinin, A., Marekov, L. N., <strong>and</strong> Steinert, P. M. (2001) Assembly of the epidermal<br />
cornified cell envelope. J. Cell Sci. 114, 3069–3070.<br />
91. McLean, W. H., Rugg, E. L., Lunny, D. P., et al. (1995) Keratin 16 <strong>and</strong> keratin 17<br />
mutations cause pachyonychia congenita. Nat. Genet. 9, 273–278.<br />
92. Wojcik, S. M., Bundman, D. S., <strong>and</strong> Roop, D. R. (2000) Delayed wound healing<br />
in keratin 6a knockout mice. Mol. Cell Biol. 20, 5248–5255.<br />
93. McGowan, K. M., Tong, X., Colucci-Guyon, E., Langa, F., Babinet, C., <strong>and</strong><br />
Coulombe, P. A. (2002) Keratin 17 null mice exhibit age- <strong>and</strong> strain-dependent<br />
alopecia. Genes Dev. 16, 1412–1422.<br />
94. Wong, P., Colucci-Guyon, E., Takahashi, K., Gu, C., Babinet, C., <strong>and</strong> Coulombe,<br />
P. A. (2000) Introducing a null mutation in the mouse K6alpha <strong>and</strong> K6beta genes<br />
reveals their essential structural role in the oral mucosa. J. Cell Biol. 150,<br />
921–928.<br />
95. Wang, Z., Wong, P., Langbein, L., Schweizer, J., <strong>and</strong> Coulombe, P. A. (2003) Type II<br />
epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, <strong>and</strong><br />
medulla in anagen-stage hair follicles. J. Invest. Dermatol. 121, 1276–1282.<br />
96. Wojcik, S. M., Longley, M. A., <strong>and</strong> Roop, D. R. (2001) <strong>Discovery</strong> of a novel<br />
murine keratin 6 (K6) isoform explains the absence of hair <strong>and</strong> nail defects in<br />
mice deficient for K6a <strong>and</strong> K6b. J. Cell Biol. 154, 619–630.<br />
97. Wong, P., Domergue, R., <strong>and</strong> Coulombe, P. A. (2005) Overcoming functional<br />
redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.<br />
Mol. Cell Biol. 25, 197–205.<br />
98. Wong, P. <strong>and</strong> Coulombe, P. A. (2003) Loss of keratin 6 (K6) proteins reveals a function<br />
for intermediate filaments during wound repair. J. Cell Biol. 163, 327–337.<br />
99. Wojcik, S. M., Imakado, S., Seki, T., et al. (1999) Expression of MK6a dominantnegative<br />
<strong>and</strong> C-terminal mutant transgenes in mice has distinct phenotypic consequences<br />
in the epidermis <strong>and</strong> hair follicle. Differentiation 65, 97–112.<br />
100. Paladini, R. D. <strong>and</strong> Coulombe, P. A. (1999) The functional diversity of epidermal<br />
keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16.<br />
J. Cell Biol. 146, 1185–1201.