Target Discovery and Validation Reviews and Protocols

248 Vijayaraj, Söhl, and Magin
68. Kowalczyk, A. P., Bornslaeger, E. A., Norvell, S. M., Palka, H. L., and Green, K. J.
(1999) Desmosomes: intercellular adhesive junctions specialized for attachment
of intermediate filaments. Int. Rev. Cytol. 185, 237–302.
69. Smith, E. A. and Fuchs, E. (1998) Defining the interactions between intermediate
filaments and desmosomes. J. Cell Biol. 141, 1229–1241.
70. Hutton, E., Paladini, R. D., Yu, Q. C., Yen, M., Coulombe, P. A., and Fuchs, E.
(1998) Functional differences between keratins of stratified and simple epithelia.
J. Cell Biol. 143, 487–499.
71. Fuchs, E. (1995) Keratins and the skin. Annu. Rev. Cell Dev. Biol. 11, 123–153.
72. Cao, T., Longley, M. A., Wang, X. J., and Roop, D. R. (2001) An inducible mouse
model for epidermolysis bullosa simplex: implications for gene therapy. J. Cell
Biol. 152, 651–656.
73. Berton, T. R., Wang, X. J., Zhou, Z., et al. (2000) Characterization of an inducible,
epidermal-specific knockout system: differential expression of lacZ in different
Cre reporter mouse strains. Genesis 26, 160–161.
74. Fuchs, E. and Green, H. (1980) Changes in keratin gene expression during terminal
differentiation of the keratinocyte. Cell 19, 1033–1042.
75. Reichelt, J., Bussow, H., Grund, C., and Magin, T. M. (2001) Formation of a normal
epidermis supported by increased stability of keratins 5 and 14 in keratin
10 null mice. Mol. Biol. Cell 12, 1557–1568.
76. van Hemert, M. J., Steensma, H. Y., and van Heusden, G. P. (2001) 14-3-3 proteins:
key regulators of cell division, signalling and apoptosis. Bioessays 23, 936–946.
77. Reichelt, J. and Magin, T. M. (2002) Hyperproliferation, induction of c-Myc and
14-3-3sigma, but no cell fragility in keratin-10-null mice. J. Cell Sci. 115,
2639–2650.
78. Paramio, J. M. and Jorcano, J. L. (2002) Beyond structure: do intermediate filaments
modulate cell signalling? Bioessays 24, 836–844.
79. Reichelt, J., Breiden, B., Sandhoff, K., and Magin, T. M. (2004a) Loss of keratin
10 is accompanied by increased sebocyte proliferation and differentiation. Eur. J.
Cell Biol. 83, 747–759.
80. Reichelt, J., Furstenberger, G., and Magin, T. M. (2004b) Loss of keratin 10 leads to
mitogen-activated protein kinase (MAPK) activation, increased keratinocyte
turnover, and decreased tumor formation in mice. J. Invest. Dermatol. 123, 973–981.
81. Porter, R. M., Leitgeb, S., Melton, D. W., Swensson, O., Eady, R. A., and Magin,
T. M. (1996) Gene targeting at the mouse cytokeratin 10 locus: severe skin
fragility and changes of cytokeratin expression in the epidermis. J. Cell Biol. 132,
925–936.
82. Reichelt, J., Bauer, C., Porter, R., Lane, E., and Magin, V. (1997) Out of balance:
consequences of a partial keratin 10 knockout. J. Cell Sci. 110 (18), 2175–2186.
83. Elias, P., Man, M. Q., Williams, M. L., Feingold, K. R., and Magin, T. (2000) Barrier
function in K-10 heterozygote knockout mice. J. Invest. Dermatol. 114, 396, 397.
84. Reichelt, J., Doering, T., Schnetz, E., Fartasch, M., Sandhoff, K., and Magin, A.
M. (1999) Normal ultrastructure, but altered stratum corneum lipid and protein
composition in a mouse model for epidermolytic hyperkeratosis. J. Investig.
Dermatol. 113, 329–334.