Target Discovery and Validation Reviews and Protocols

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Transgenic Models 201 138. Ranger, A. M., Malynn, B. A., and Korsmeyer, S. J. (2001) Mouse models of cell death. Nat. Genet. 28, 113–118. 139. De Boer, J., Andressoo, J. O., De Wit, J., et al. (2002) Premature aging in mice deficient in DNA repair and transcription. Science 296, 1276–1279. 140. Miller, M. W. and Rubin, E. M. (1997) Transgenic animals in atherosclerosis research, in Transgenic Animal and Generation and Use (L. M. Houdebine, ed.), Harwood Academic Publishers, Amsterdam, pp. 445–448. 141. Fan, J. and Watanabe, T. (2003) Transgenic rabbits as therapeutic protein bioreactors and human disease models. Pharmacol. Ther. 99, 261–282. 142. Siegel, P. M., Hardy, W. R., and Muller, W. J. (2000) Mammary gland neoplasia: insights from transgenic mouse models. Bioessays 22, 554–563. 143. Bartek, J. and Lukas, J. (2001) Are all cancer genes equal? Nature 411, 1001–1002. 144. Yu, Q., Geng, Y., and Sicinski, P. (2001) Specific protection against breast cancers by cyclin D1 ablation. Nature 411, 1017–1021. 145. Schwertfeger, K. L., Richert, M. M., and Anderson, S. M. (2001) Mammary gland involution is delayed by activated Akt in transgenic mice. Mol. Endocrinol. 15, 867–881. 146. Berns, A. (2001) Cancer. Improved mouse models. Nature 410, 1043–1044. 147. Johnson, L., Mercer, K., Greenbaum, D., et al. (2001) Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410, 1111–1116. 148. Lecuit, M., Vandormael-Pournin, S., Lefort, J., et al. (2001) A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier. Science 292, 1722–1725. 149. Oldstone, M. B., Lewicki, H., Thomas, D., et al. (1999) Measles virus infection in a transgenic model: virus-induced immunosuppression and central nervous system disease. Cell 98, 629–640. 150. Ren, R. B., Costantini, F., Gorgacz, E. J., Lee, J. J., and Racaniello, V. R. (1990) Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. Cell 63, 353–362. 151. Fausto, N. (2001) A mouse model for hepatitis C virus infection? Nat. Med. 7, 890–891. 152. Dunn, C. S., Mehtali, M., Houdebine, L. M., Gut, J. P., Kirn, A., and Aubertin, A. M. (1995) Human immunodeficiency virus type 1 infection of human CD4-transgenic rabbits. J. Gene. Virol. 76, 1327–1336. 153. Cohen, J. (2001) Building a small-animal model for AIDS, block by block. Science 293, 1034–1036. 154. Reid, W., Sadowska, M., Denaro, F., et al. (2001) An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction. Proc. Natl. Acad. Sci. USA 98, 9271–9276. 155. Carvallo, G., Canard, G., and Tucker, D. (1997) Standardization of transgenic lines: from founder to an established animal model, in Transgenic Animal Generation and Use (Houdebine, L. M., ed.), Harwood Academic Publishers, Amsterdam, pp. 403–410.
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METHODS IN MOLECULAR BIOLOGY 360 T
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M E T H O D S I N M O L E C U L A R
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© 2007 Humana Press Inc. 999 River
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vi Preface get. Approaches to targe
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viii Contents 10 Transgenic Animal
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x Contributors SAHOHIME MATSUMOTO
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xii Contents of Volume 2 12 Validat
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2 Sioud disease pathogenesis and pe
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4 Sioud A more fruitful approach fo
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6 Sioud both transient and permanen
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8 Sioud serum biomarkers. This syne
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10 Sioud Fig. 2. Schematic of targe
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12 Sioud 13. Magin, T. M. (1998) Le
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Harnessing the Human Genome 15 The
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Harnessing the Human Genome 17 Fig.
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Harnessing the Human Genome 23 The
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Harnessing the Human Genome 27 repr
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Harnessing the Human Genome 29 14.
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Harnessing the Human Genome 31 45.
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34 Imoto et al. (4,5), and Bayesian
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36 Imoto et al. 2. Materials Two ty
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38 Imoto et al. Fig. 3. Graphical v
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40 Imoto et al. Fig. 5. Result of t
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42 Imoto et al. p(D |G) = ∫ p(D,
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44 Imoto et al. β k (k = 1,…,q j
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46 Imoto et al. Fig. 7. Partial res
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48 Imoto et al. Fig. 8. Strategy to
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50 Imoto et al. Fig. 9. (continued)
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52 Imoto et al. Table 3 List of Roo
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54 Imoto et al. 5. De Hoon, M. J. L
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56 Imoto et al. 39. Kamimura, T., S
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58 Beaty et al. cytotoxic drugs and
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60 Beaty et al. Fig. 1. Principles
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62 Beaty et al. oligonucleotide mic
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64 Beaty et al. 3. The 12% polyacry
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66 Beaty et al. 2.3.3. Protein Stai
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68 Beaty et al. 3.1.3. Labeling of
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70 Beaty et al. 1 µL of the anneal
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72 Beaty et al. 4. Phenol:cholorfor
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74 Beaty et al. 19. Wash twice with
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76 Beaty et al. The Following Volum
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78 Beaty et al. using a protein ass
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80 Beaty et al. 6. Shake the gel fo
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82 Beaty et al. Fig. 2. Preparation
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84 Beaty et al. search in. A widely
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86 Beaty et al. 3. Kern, S. E., Hru
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88 Beaty et al. 34. Peters, D. G.,
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5 Molecular Classification of Breas
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Molecular Profiling of Breast Cance
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Fig. 2. (Continued) the right ident
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6 Discovery of Differentially Expre
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Gene Target Discovery 117 In the fi
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Gene Target Discovery 119 sequences
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Gene Target Discovery 121 There is
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Gene Target Discovery 123 digestion
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Gene Target Discovery 125 Fig. 1. P
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Gene Target Discovery 127 5. Sargen
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Gene Target Discovery 129 41. Berry
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132 Matsumoto, Miyagishi, and Taira
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144 Fig. 1. The ribozyme-expression
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146 Sano and Taira 5. 10X L (low-sa
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148 Sano and Taira ribozymes may cl
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Page 177 and 178: 164 Houdebine Fig. 1. Different met
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Page 181 and 182: 168 Houdebine Fig. 2. Major methods
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Page 187 and 188: 174 Houdebine as insulators. The co
Page 189 and 190: 176 Houdebine Fig. 5. Different met
Page 191 and 192: 178 Houdebine systems. Moreover, st
Page 193 and 194: 180 Houdebine contribute to generat
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12 The HUVEC/Matrigel Assay An In V
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256 Skovseth, Küchler, and Haralds
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270 Iversen and Sørensen witnessed
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272 Iversen and Sørensen Fig. 1. P
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274 Iversen and Sørensen the core
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14 An Overview of the Immune System
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Overview of Immune System 279 diffe
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Overview of Immune System 281 Fig.
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Overview of Immune System 283 then
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Overview of Immune System 285 expre
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Overview of Immune System 287 Once
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Overview of Immune System 289 solub
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Overview of Immune System 291 amino
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Overview of Immune System 293 (unre
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Overview of Immune System 297 the c
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Overview of Immune System 299 (44).
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Overview of Immune System 301 demon
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Overview of Immune System 307 some
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Overview of Immune System 309 sera
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Overview of Immune System 313 measu
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Overview of Immune System 315 42. H
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Overview of Immune System 317 74. D
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15 Potential Target Antigens for Im
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Tumor Antigen Discovery 321 develop
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Tumor Antigen Discovery 323 panel b
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Tumor Antigen Discovery 325 16. Joc
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16 Identification of Tumor Antigens
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Immunoproteomics 329 by “shot gun
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Immunoproteomics 331 isoelectric fo
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Immunoproteomics 333 3. 2D-PAGE is
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17 Protein Arrays A Versatile Toolb
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Protein Arrays 337 Table 1 Classifi
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Protein Arrays 339 fractions from c
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Protein Arrays 341 combinatorial sc
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Protein Arrays 343 The ideal proteo
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Protein Arrays 345 18. Cekaite, H.
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Protein Arrays 347 49. Yuko Kawahas
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Index 349 Index A Acetyl-CoA carbox
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Index 351 conditional by using FRT
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Index 353 Recombinant tumor antigen
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