Target Discovery and Validation Reviews and Protocols

200 Houdebine
121. Pailhoux, E., Vigier, B., Chaffaux, S., et al. (2001) A 11.7-kb deletion triggers
intersexuality and polledness in goats. Nat. Genet. 29, 453–458.
122. Vaiman, D. (2003) Sexy transgenes: the impact of gene transfer and gene inactivation
technologies on the understanding of mammalian sex determination.
Transgenic Res. 12, 255–269.
123. Shillingford, J. M. and Henneighausen, L. (2001) Experimental mouse geneticsanswering
fundamental questions about mamary gland biology. Trends Endocrinol
Metab 12, 402–408.
124. Kong, J. and Xu, Z. (2000) Overexpression of neurofilament subunit NF-L and
NF-H extends survival of a mouse model for amyotrophic lateral sclerosis.
Neurosci Lett. 281, 72–74.
125. Moll, J., Barzaghi, P., Lin, S., et al. (2001) An agrin minigene rescues dystrophic
symptoms in a mouse model for congenital muscular dystrophy. Nature 413,
302–307.
126. Esler, W. P. and Wolfe, M. S. (2001) A portrait of Alzheimer secretases—new
features and familiar faces. Science 293, 1449–1454.
127. Lewis, J., Dickson, D. W., Lin, W. L., et al. (2001) Enhanced neurofibrillary
degeneration in transgenic mice expressing mutant tau and APP. Science 293,
1487–1491.
128. Chapman, P. F., Falinska, A. M., Knevett, S. G., and Ramsay, M. F. (2001) Genes,
models and Alzheimer’s disease. Trends Genet. 17, 254–261.
129. Moore, R. C. and Melton, D. W. (1997) Transgenic analysis of prion diseases.
Mol. Hum. Reprod. 3, 529–544.
130. Prusiner, S. B., Scott, M. R., DeArmond, S. J., and Cohen, F. E. (1998) Prion protein
biology. Cell 93, 337–348.
131. Scott, M. R., Will, R., Ironside, J., et al. (1999) Compelling transgenetic evidence
for transmission of bovine spongiform encephalopathy prions to humans. Proc.
Natl. Acad. Sci. USA 96, 15,137–15,142.
132. Raeber, A. J., Race, R. E., Brandner, S., et al. (1997) Astrocyte-specific expression
of hamster prion protein (PrP) renders PrP knockout mice susceptible to
hamster scrapie. EMBO J. 16, 6057–6065.
133. Scott, M. R., Safar, J., Telling, G., et al. (1997) Identification of a prion protein
epitope modulating transmission of bovine spongiform encephalopathy prions to
transgenic mice. Proc. Natl. Acad. Sci. USA 94, 14,279–14,284.
134. Manolakou, K., Beaton, J., McConnell, I., et al. (2001) Genetic and environmental
factors modify bovine spongiform encephalopathy incubation period in mice.
Proc. Natl. Acad. Sci. USA 98, 7402–7407.
135. Vilette, D., Andreoletti, O., Archer, F., et al. (2001) Ex vivo propagation of infectious
sheep scrapie agent in heterologous epithelial cells expressing ovine prion
protein. Proc. Natl. Acad. Sci. USA 98, 4055–4059.
136. Betarbet, R., Sherer, T. B., and Greenamyre, J. T. (2002) Animal models of
Parkinson’s disease. Bioessays 24, 308–318.
137. Rubinsztein, D. C. (2002) Lessons from animal models of Huntington’s disease.
Trends Genet. 18, 202–209.