Target Discovery and Validation Reviews and Protocols

198 Houdebine
86. Carmichael, G. G. (2003) Antisense starts making more sense. Nat. Biotechnol.
21, 371–372.
87. Ying, S. Y. and Lin, S. L. (2004) Intron-derived microRNAs—fine tuning of gene
functions. Gene 342, 25–28.
88. Ying, S. Y. and Lin, S. L. (2005) Intronic microRNAs. Biochem. Biophys. Res.
Commun 326, 515–520.
89. Kawasaki, H. and Taira, K. (2004) Induction of DNA methylation and gene
silencing by short interfering RNAs in human cells. Nature 431, 211–217.
90. Morris, K. V., Chan, S. W., Jacobsen, S. E., and Looney, D. J. (2004) Small interfering
RNA-induced transcriptional gene silencing in human cells. Science 305,
1289–1292.
91. Zeng, Y., Yi, R., and Cullen, B. R. (2003) MicroRNAs and small interfering RNAs
can inhibit mRNA expression by similar mechanisms. Proc. Natl. Acad. Sci. USA
100, 9779–9784.
92. He, L. and Hannon, G. J. (2004) MicroRNAs: small RNAs with a big role in gene
regulation. Nat. Rev. Genet. 5, 522–531.
93. Xie, X., Lu, J., Kulbokas, E. J., et al. (2005) Systematic discovery of regulatory
motifs in human promoters and 3′ UTRs by comparison of several mammals.
Nature 434, 338–345.
94. Lee, Y., Kim, M., Han, J., et al. (2004) MicroRNA genes are transcribed by RNA
polymerase II. EMBO J. 23, 4051–4060.
95. Zeng, Y. and Cullen, B. R. (2003) Sequence requirements for micro RNA processing
and function in human cells. RNA 9, 112–123.
96. Ecclestin, A. and Eggleston, A. K. (2004) RNA interference. Nature 431, 337–378.
97. Clayton, J. (2004) RNA interference: the silent treatment. Nature 431, 599–605.
98. Müller, M. (2000) Increasing disease resistance in transgenic domestic, in Molecular
Farming (Toutant, J. P. and Balazs, E., eds.), INRA Editions, Paris, pp. 87–98.
99. Jones, S. D. and Marasco, W. A. (1997) Intracellular antibodies (intrabodies):
potential applications in transgenic animal research and engineered resistance to
pathogens, in Transgenic Animal Generation and Use (Houdebine, L. M., ed.),
Harwood Academic Publishers, Amsterdam, pp. 501–506.
100. Chang, P. Y., Benecke, H., Le Marchand-Brustel, Y., Lawitts, J., and Moller, D. E.
(1994) Expression of a dominant-negative mutant human insulin receptor in the
muscle of transgenic mice. J. Biol. Chem. 269, 16,034–16,040.
101. Ono, E., Amagai, K., Taharaguchi, S., et al. (2004) Transgenic mice expressing a
soluble form of porcine nectin-1/herpesvirus entry mediator C as a model for
pseudorabies-resistant livestock. Proc. Natl. Acad. Sci. USA 101, 16,150–16,155.
102. Chen,Y. T., Levasseur, R., Vaishnav, S., Karsenty, G., and Bradley, A. (2004) Bigenic
Cre/loxP, puDeltatk conditional genetic ablation. Nucleic Acids Res. 32, e161.
103. Saito, M., Iwawaki, T., Taya, C., et al. (2001) Diphtheria toxin receptor-mediated conditional
and targeted cell ablation in transgenic mice. Nat. Biotechnol. 19, 746–750.
104. Jiang, W., Zhou, L., Breyer, B., et al. (2001) Tetracycline-regulated gene expression
mediated by a novel chimeric repressor that recruits histone deacetylases in
mammalian cells. J. Biol. Chem. 276, 45,168–45,174.