Target Discovery and Validation Reviews and Protocols

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Contents of Volume 2: Emerging Molecular Targets and Treatment Options 1 Druggable Signaling Proteins Mouldy Sioud and Marianne Leirdal 2 DNA Methylation and Histone Modifications in Patients With Cancer: Potential Prognostic and Therapeutic Targets Michel Herranz and Manel Esteller 3 Wnt Signaling as a Therapeutic Target for Cancer Andreas Herbst and Frank Thomas Kolligs 4 The Ng2/Hmp Proteoglycan as a Cancer Therapeutic Target Martha Chekenya and Heike Immervoll 5 Heterotrimeric G Proteins and Disease Øyvind Melien 6 High-Mobility Group Box-1 Isoforms as Potential Therapeutic Targets in Sepsis William Parrish and Luis Ulloa 7 Antisense Oligonucleotides: Target Validation and Development of Systemically Delivered Therapeutic Nanoparticles Chuanbo Zhang, Jin Pei, Deepak Kumar, Isamu Sakabe, Howard E. Boudreau, Prafulla C. Gokhale, and Usha N. Kasid 8 Nucleic Acid-Based Aptamers as Promising Therapeutics in Neoplastic Diseases Laura Cerchia and Vittorio de Franciscis 9 Guidelines for the Selection of Effective Short-Interfering RNA Sequences for Functional Genomics Kumiko Ui-Tei, Yuki Naito, and Kaoru Saigo 10 Suppression of Apoptosis in the Liver by Systemic and Local Delivery of Small-Interfering RNA Lars Zender and Stefan Kubicka 11 Target Validation Using RNA Interference in Solid Tumors Seyedhossein Aharinejad, Mouldy Sioud, Trevor Lucas, and Dietmar Abraham xi
xii Contents of Volume 2 12 Validation of Telomerase and Survivin as Anticancer Therapeutic Targets Using Ribozymes and Small-Interfering RNAs Nadia Zaffaroni, Marzia Pennati, and Marco Folini 13 Collagen-Induced Arthritis in Mice: A Major Role for Tumor Necrosis Factor-α Richard O. Williams 14 Novel Opportunities for Therapeutic Targeting in Systemic Autoimmune Diseases Meryem Ouarzane and Moncef Zouali 15 Considerations for Target Validation and Industrial Approaches Carlos R. Plata-Salamán and Sergey E. Ilyin 16 Regulatory RNAs: Future Perspectives in Diagnosis, Prognosis, and Individualized Therapy Marjorie P. Perron, Vincent Boissonneault, Lise-Andrée Gobeil, Dominique L. Ouellet, and Patrick Provost 17 Treatment Options and Individualized Medicine Mouldy Sioud and Øyvind Melien
Page 1 and 2: METHODS IN MOLECULAR BIOLOGY 360 T
Page 3 and 4: M E T H O D S I N M O L E C U L A R
Page 5 and 6: © 2007 Humana Press Inc. 999 River
Page 7 and 8: vi Preface get. Approaches to targe
Page 9 and 10: viii Contents 10 Transgenic Animal
Page 11: x Contributors SAHOHIME MATSUMOTO
Page 15 and 16: 2 Sioud disease pathogenesis and pe
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50 Imoto et al. Fig. 9. (continued)
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52 Imoto et al. Table 3 List of Roo
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54 Imoto et al. 5. De Hoon, M. J. L
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56 Imoto et al. 39. Kamimura, T., S
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58 Beaty et al. cytotoxic drugs and
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60 Beaty et al. Fig. 1. Principles
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62 Beaty et al. oligonucleotide mic
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64 Beaty et al. 3. The 12% polyacry
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66 Beaty et al. 2.3.3. Protein Stai
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68 Beaty et al. 3.1.3. Labeling of
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70 Beaty et al. 1 µL of the anneal
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72 Beaty et al. 4. Phenol:cholorfor
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74 Beaty et al. 19. Wash twice with
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76 Beaty et al. The Following Volum
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78 Beaty et al. using a protein ass
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80 Beaty et al. 6. Shake the gel fo
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82 Beaty et al. Fig. 2. Preparation
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84 Beaty et al. search in. A widely
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86 Beaty et al. 3. Kern, S. E., Hru
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88 Beaty et al. 34. Peters, D. G.,
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5 Molecular Classification of Breas
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Molecular Profiling of Breast Cance
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Fig. 2. (Continued) the right ident
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6 Discovery of Differentially Expre
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Gene Target Discovery 117 In the fi
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Gene Target Discovery 119 sequences
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Gene Target Discovery 121 There is
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Gene Target Discovery 123 digestion
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Gene Target Discovery 125 Fig. 1. P
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Gene Target Discovery 127 5. Sargen
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Gene Target Discovery 129 41. Berry
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132 Matsumoto, Miyagishi, and Taira
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144 Fig. 1. The ribozyme-expression
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146 Sano and Taira 5. 10X L (low-sa
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148 Sano and Taira ribozymes may cl
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150 Fig. 3. A system for the identi
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152 Sano and Taira 4. Notes 1. We r
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9 Production of siRNA- and cDNA-Tra
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Transfected Cell Arrays 157 Fig. 1.
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Transfected Cell Arrays 159 2. The
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Transfected Cell Arrays 161 5. Simp
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164 Houdebine Fig. 1. Different met
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166 Houdebine concentrations become
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168 Houdebine Fig. 2. Major methods
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170 Houdebine integrate into the me
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172 Houdebine 2.2.3. Knock-In Into
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174 Houdebine as insulators. The co
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176 Houdebine Fig. 5. Different met
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178 Houdebine systems. Moreover, st
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180 Houdebine contribute to generat
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182 Houdebine Fig.7. Example of a v
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184 Houdebine more extensively. Tra
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186 Houdebine and stroma. Several o
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188 Houdebine explained at the mole
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190 Houdebine of the intestinal epi
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192 Houdebine interference of the g
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194 Houdebine 17. Whitelaw, C. B. A
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196 Houdebine 51. Bell, A. C., West
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198 Houdebine 86. Carmichael, G. G.
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200 Houdebine 121. Pailhoux, E., Vi
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202 Houdebine 156. Auerbach, A. B.,
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204 Vijayaraj, Söhl, and Magin 1.
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206 Vijayaraj, Söhl, and Magin Fig
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208 Vijayaraj, Söhl, and Magin fil
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210 Table 1 Orthologous Human and M
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212 Table 2 Orthologous Human and M
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214 Vijayaraj, Söhl, and Magin ulc
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216 Vijayaraj, Söhl, and Magin of
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218 Vijayaraj, Söhl, and Magin sug
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220 Vijayaraj, Söhl, and Magin abs
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222 Vijayaraj, Söhl, and Magin 1.2
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224 Vijayaraj, Söhl, and Magin Fig
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226 Vijayaraj, Söhl, and Magin gen
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228 Vijayaraj, Söhl, and Magin the
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230 Vijayaraj, Söhl, and Magin f.
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234 Vijayaraj, Söhl, and Magin b.
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240 Vijayaraj, Söhl, and Magin alt
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242 Table 3 Time Schedule For Aggre
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250 Vijayaraj, Söhl, and Magin 101
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12 The HUVEC/Matrigel Assay An In V
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256 Skovseth, Küchler, and Haralds
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270 Iversen and Sørensen witnessed
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272 Iversen and Sørensen Fig. 1. P
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274 Iversen and Sørensen the core
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14 An Overview of the Immune System
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Overview of Immune System 279 diffe
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Overview of Immune System 281 Fig.
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Overview of Immune System 283 then
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Overview of Immune System 285 expre
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Overview of Immune System 287 Once
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Overview of Immune System 289 solub
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Overview of Immune System 291 amino
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Overview of Immune System 293 (unre
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Overview of Immune System 297 the c
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Overview of Immune System 299 (44).
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Overview of Immune System 301 demon
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Overview of Immune System 307 some
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Overview of Immune System 309 sera
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Overview of Immune System 313 measu
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Overview of Immune System 315 42. H
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Overview of Immune System 317 74. D
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15 Potential Target Antigens for Im
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Tumor Antigen Discovery 321 develop
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Tumor Antigen Discovery 323 panel b
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Tumor Antigen Discovery 325 16. Joc
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16 Identification of Tumor Antigens
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Immunoproteomics 329 by “shot gun
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Immunoproteomics 331 isoelectric fo
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Immunoproteomics 333 3. 2D-PAGE is
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17 Protein Arrays A Versatile Toolb
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Protein Arrays 337 Table 1 Classifi
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Protein Arrays 339 fractions from c
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Protein Arrays 341 combinatorial sc
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Protein Arrays 343 The ideal proteo
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Protein Arrays 345 18. Cekaite, H.
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Protein Arrays 347 49. Yuko Kawahas
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Index 349 Index A Acetyl-CoA carbox
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Index 351 conditional by using FRT
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Index 353 Recombinant tumor antigen
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