Establishing a Relationship between Disintegration and Dissolution
Establishing a Relationship between Disintegration and Dissolution
Establishing a Relationship between Disintegration and Dissolution
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<strong>Establishing</strong> a relationship:<br />
Results BCS<br />
Solubility:<br />
• data prove good solubility<br />
Permeability:<br />
• data prove good permeability<br />
therefore, substance M is a BCS class I compound<br />
© PHAST GmbH, www.phast.de 25<br />
Results: <strong>Dissolution</strong> kinetics<br />
product name<br />
/ geometry<br />
pH 5 10 15 20 25 30 45<br />
M / 1.2 102.8 103.1 103.3 102.6 102.4 102.9 102.6<br />
4.5 86.5 90.9 94.3 96.7 96.5 96.8 99.4<br />
6.8 92.3 96.7 98.3 100.2 101.1 100.4 101.9<br />
1.2 102.8 103.1 103.3 102.6 102.4 102.9 102.6<br />
4.5 86.5 90.9 94.3 96.7 96.5 96.8 99.4<br />
dissolution >> 80% in 30 min <strong>and</strong> in 15 min<br />
© PHAST GmbH, www.phast.de 26<br />
12/18/2009<br />
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