Summary of Health and Safety Test Results - Invitrogen

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Mens Sana in Corpore Sano.
(translation: A healthy mind in a healthy body.)
SYBR Safe DNA gel stain promotes safety by removing a
known health hazard—ethidium bromide—from your lab.
Ethidium bromide is so commonplace in molecular biology labs
that it’s easy to forget how hazardous it is. However, ethidium
bromide is a known carcinogen and a powerful mutagen,
making it both a health hazard and a disposal headache. There
has long been a need for a safer nucleic acid gel stain, and now
it’s here. Specifi cally developed to enhance lab safety without
compromising staining performance, SYBR Safe DNA gel stain
is less mutagenic, less toxic, more environmentally friendly, and
it works with traditional gel staining methods.
Further Information
SYBR Safe DNA gel stain provides:
n Safety—Less mutagenic than ethidium bromide;
tests negative for genotoxicity and acute oral toxicity
(LD 50 >5000 mg/kg)
n Low Environmental Impact—Not classifi ed as a hazardous
waste; meets the requirements of the Clean Water Act
n Sensitivity—Uncompromised detection sensitivity as com-
pared to ethidium bromide
n Convenience—Provided as a concentrate or as a ready-to-use
solution in TBE or TAE buff er; can be precast in gels or used as
a post-stain
n Speed—No destaining required; can be cast directly in the gel
n Compatibility—Use with a standard UV epi- or trans-
illuminator, a visible-light transilluminator, or a laser-based
scanner
This document is intended to present a brief summary of the safety and environmental data
gathered so far about our SYBR Safe DNA gel stain. Further information—including detailed
performance and safety results—can be accessed at probes.invitrogen.com/sybrsafe.
We want to help you solve your disposal problems.
If your local disposal agencies require additional
tests or data, please let us know by sending an
e-mail to sybrsafe@invitrogen.com.
Important Licensing Information
These products may be covered by one or more Limited Use Label Licenses (see the Invitrogen website,
www.invitrogen.com, or the Molecular Probes website, probes.invitrogen.com). By use of these products
you accept the terms and conditions of all applicable Limited Use Label Licenses. All products are for
research use only. CAUTION: Not intended for human or animal diagnostic or therapeutic uses.