d(GC) - Association of Biotechnology and Pharmacy
d(GC) - Association of Biotechnology and Pharmacy
d(GC) - Association of Biotechnology and Pharmacy
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Current Trends in <strong>Biotechnology</strong> <strong>and</strong> <strong>Pharmacy</strong><br />
Vol. 6 (2) 166-172 April 2012, ISSN 0973-8916 (Print), 2230-7303 (Online)<br />
the invitro systems. Antitrypsin provided<br />
significant improvement in stability when<br />
compared to other inhibitors <strong>of</strong> ecto-peptidases.<br />
The lipoprotein based drug delivery approach<br />
<strong>of</strong>fered better tumor barrier penetration due to<br />
the proposed endocytotic uptake <strong>and</strong> also helped<br />
in maintaining the immunogenic potential <strong>of</strong> the<br />
peptide. Thus, the in vitro results indicate that<br />
these delivery approaches have potential in<br />
improving in vivo efficacy <strong>of</strong> PADRE.<br />
References<br />
1. Ruddy, K. (2008). Immunotherapy for breast<br />
cancer. The Breast Cancer Report, 1 (1).<br />
2. Piura, E. <strong>and</strong> Piura, B. (2011). Autoantibodies<br />
to Tailor-Made Panels <strong>of</strong> Tumor-<br />
Associated Antigens in Breast Carcinoma.<br />
Journal <strong>of</strong> Oncology, 2011. Article ID 982425.<br />
3. Parmiani, G., Castelli, C., Dalebra, P.,<br />
Mortarini, R., Rivoltini L., Marincola F. <strong>and</strong><br />
Anichini, A. (2002). Cancer Immunotherapy<br />
With Peptide-Based Vaccines: What Have<br />
We Achieved? Where Are We Going?<br />
Journal <strong>of</strong> the National Cancer Institute, 94<br />
(11): 805-818.<br />
4. Wenning, L. <strong>and</strong> Murphy, R. (1999). Coupled<br />
cellular trafficking <strong>and</strong> diffusional limitations<br />
in delivery <strong>of</strong> immunotoxins to multicell tumor<br />
spheroids. <strong>Biotechnology</strong> <strong>and</strong><br />
5.<br />
Bioengineering, 62: 562-75.<br />
Poondru, S., Marasanapalle, V., Saraf, P. <strong>and</strong><br />
Jasti, B. (2012). Development <strong>and</strong> Validation<br />
<strong>of</strong> Reversed Phase HPLC Method for<br />
Analysis <strong>of</strong> Immunotherapeutic Peptide<br />
PADRE <strong>and</strong> its Applications. Current Trends<br />
in <strong>Biotechnology</strong> <strong>and</strong> <strong>Pharmacy</strong>, 6 (1):35-43.<br />
6. Takaori, K., Burton, J. <strong>and</strong> Donowitz, M.<br />
(1986). The transport <strong>of</strong> an intact<br />
oligopeptide across adult mammalian<br />
jejunum. Biochemical <strong>and</strong> Biophysical<br />
Research Communications, 137: 682-687.<br />
7. Ziv, E., Lior, O., Kidron, M. (1987). Absorption<br />
<strong>of</strong> protein via the intestinal wall. A quantitative<br />
model. Biochemical Pharmacology, 36:<br />
1035-1039.<br />
Delivery Strategies to improve PADRE<br />
172<br />
8. Dubowchik, G.M. <strong>and</strong> Walker, M.A. (1999).<br />
Receptor-mediated <strong>and</strong> enzyme-dependent<br />
targeting <strong>of</strong> cytotoxic anticancer drugs.<br />
Pharmacology <strong>and</strong> Therapeutics, 83: 67-123.<br />
9. Masquelier, M., Vitols, S., Pålsson M., Mårs,<br />
U., Larsson, B.S. <strong>and</strong> Peterson, C.O. (2000).<br />
Low density lipoprotein as a carrier <strong>of</strong><br />
cytostatics in cancer chemotherapy: study <strong>of</strong><br />
stability <strong>of</strong> drug-carrier complexes in blood.<br />
Journal <strong>of</strong> Drug Targeting, 8(3): 155-164.<br />
10. Pierotti, A., Dong, K.W., Glucksman, M.J.,<br />
Orlowski, M. <strong>and</strong> Roberts, J.L. (1990).<br />
Molecular cloning <strong>and</strong> primary structure <strong>of</strong><br />
rat testes metalloendopeptidase EC<br />
3.4.24.15. Biochemistry, 29(45): 10323-9,<br />
Erratum in Biochemistry, (1994). Jan 18;<br />
33(2):622.<br />
11. Barrett, C.H., Dodgson, K.S. <strong>and</strong> White, G.F.<br />
(1980). Further studies on the substrate<br />
specificity <strong>and</strong> inhibition <strong>of</strong> the stereospecific<br />
CS2 secondary alkylsulpho-hydrolase <strong>of</strong><br />
Comamonas terrigena. Biochemical Journal,<br />
191: 467-473.<br />
12. Danforth, E.<strong>and</strong> Moore, R.O. (1959)<br />
Intestinal absorption <strong>of</strong> insulin in the rat.<br />
Endocrinology, 65:118-123.<br />
13. Bijsterbosch, M.K. <strong>and</strong> van Berkel, J.C.<br />
(1990). Native <strong>and</strong> modified lipoproteins as<br />
drug delivery system. Advanced Drug<br />
Delivery Reviews, 5(3): 231–251.<br />
14. Masquelier, M., Tirzitis, G., Peterson C.O.,<br />
Pålsson, M., Amolins, A., Plotniece, M.,<br />
Plotniece, A., Makarova, N. <strong>and</strong> Vitols, S.G.<br />
(2000). Plasma stability <strong>and</strong> cytotoxicity <strong>of</strong><br />
lipophilic daunorubicin derivatives<br />
incorporated into low density lipoproteins.<br />
European Journal <strong>of</strong> Medicinal Chemistry,<br />
35: 429"438.<br />
15. Honglin J., Lovell, J., Chen, J., Lin, Q., Ding,<br />
L., Ng, K., P<strong>and</strong>ey, R.K., Manoharan, M.,<br />
Zhang, Z. <strong>and</strong> Zheng G. (2012). Mechanistic<br />
Insights into LDL Nanoparticle-Mediated<br />
siRNA Delivery. Bioconjugate chemistry,<br />
23(1): 33-41.