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Current Trends in Biotechnology and Pharmacy Vol. 6 (2) 119-144 April 2012, ISSN 0973-8916 (Print), 2230-7303 (Online) 32. Contraloría de Panama. XI Censo de Población y VII de Vivienda, 2010: Resultados Finales (Volumen V: Migración y Fecundidad). Cuadro 7. . http:// www.contraloria.gob.pa/inec/ cuadros.aspx?ID=000106 Accessed 31, Jan 2012 33. Kobayashi, S., Boggon, T.J., Dayaram, T., Janne, P.A., Kocher, O., Meyerson, M., Johnson, B.E., Eck, M.J., Tenen, D.G., and Halmos, B. (2005). EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med, 352: 786-92. 34. Bos, J. (1989). ras Oncogenes in Human Cancer: A Review. Cancer Research, 49: 4682-4689. 35. Pao, W., Wang, T.Y., Riely, G.J., Miller, V.A., Pan, Q., Ladanyi, M., Zakowski, M.F., Heelan, R.T., Kris, M.G., and Varmus, H.E. (2005). KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med, 2: e17. 36. Borras, E., Jurado, I., Hernan, I., Gamundi, M.J., Dias, M., Marti, I., Mane, B., Arcusa, A., Agundez, J.A., Blanca, M., and Carballo, M. (2011). Clinical pharmacogenomic testing of KRAS, BRAF and EGFR mutations by high resolution melting analysis and ultra-deep pyrosequencing. BMC Cancer, 11: 406. 37. Chen, H.Y., Yu, S.L., Chen, C.H., Chang, G.C., Chen, C.Y., Yuan, A., Cheng, C.L., Wang, C.H., Terng, H.J., Kao, S.F., Chan, W.K., Li, H.N., Liu, C.C., Singh, S., Chen, W.J., Chen, J.J., and Yang, P.C. (2007). A five-gene signature and clinical outcome in non-small-cell lung cancer. N Engl J Med, 356: 11-20. 38. Hamilton, S. and Aaltonen, L. (2000). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive Tract. , IARC Press, Lyon, France, pp. 102-143. Rebecca E. Smith and Juan Miguel Pascale 138 39. Kwak, E.L. and Chung, D.C. (2007). Hereditary colorectal cancer syndromes: an overview. Clin Colorectal Cancer, 6: 340-4. 40. National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology: Colorectal Cancer Screening.; http:// www.nccn.org/professionals/physician_gls/ f_guidelines.asp#site Accessed 31, Aug 2011 41. Jasperson, K.W., Tuohy, T.M., Neklason, D.W., and Burt, R.W. (2010). Hereditary and familial colon cancer. Gastroenterology, 138: 2044-58. 42. Kohlmann, W. and Gruber, S.B. Lynch Syndrome. http://www.ncbi.nlm.nih.gov/ books/NBK1211/ Accessed 31, Jan 2012 43. Alonso-Espinaco, V., Giraldez, M.D., Trujillo, C., van der Klift, H., Munoz, J., Balaguer, F., Ocana, T., Madrigal, I., Jones, A.M., Echeverry, M.M., Velez, A., Tomlinson, I., Mila, M., Wijnen, J., Carvajal- Carmona, L., Castells, A., and Castellvi-Bel, S. (2011). Novel MLH1 duplication identified in Colombian families with Lynch syndrome. Genet Med, 13: 155-60. 44. Giraldo, A., Gomez, A., Salguero, G., Garcia, H., Aristizabal, F., Gutierrez, O., Angel, L.A., Padron, J., Martinez, C., Martinez, H., Malaver, O., Florez, L., and Barvo, R. (2005). MLH1 and MSH2 mutations in Colombian families with hereditary nonpolyposis colorectal cancer (Lynch syndrome)—description of four novel mutations. Fam Cancer, 4: 285-90. 45. Gomez, A., Salguero, G., Garcia, H., Aristizabal, F., Gutierrez, O., Angel, L.A., Padron, J., Martinez, C., Martinez, H., Malaver, O., Barvo, R., and Giraldo, A. (2005). Detection mutations in the DNA mismatch repair genes of hMLH1 and hMSH2 genes in Colombian families with suspicion of hereditary non-polyposis colorectal carcinoma (Lynch syndrome). Biomedica, 25: 315-24.
Current Trends in Biotechnology and Pharmacy Vol. 6 (2) 119-144 April 2012, ISSN 0973-8916 (Print), 2230-7303 (Online) 46. Torres-Machorro, A., Aragon-Anzures, A., Barrera-Perez, M., Chavez-Tapia, N.C., and Valdovinos, M.A. (2006). Hereditary nonpolyposis colorectal cancer (Lynch syndrome). Clinical case. Rev 47. Gastroenterol Mex, 71: 312-5. Mendoza Sanchez, A., Sobrino Cossio, S., Hernandez Guerrero, A., Cordova Pluma, V.H., Alonso Larraga, O., and Sanchez del Monte, D.J. (2005). Utility of diagnostic scales for hereditary non-polyposis colon cancer in the Mexican population. Rev Gastroenterol Mex, 70: 411-5. 48. Liu, B., Parsons, R., Papadopoulos, N., Nicolaides, N.C., Lynch, H.T., Watson, P., Jass, J.R., Dunlop, M., Wyllie, A., Peltomaki, P., de la Chapelle, A., Hamilton, S.R., Vogelstein, B., and Kinzler, K.W. (1996). Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med, 2: 169-74. 49. Online Mendelian Inheritance in Man. EXONUCLEASE 1, S. CEREVISIAE, HOMOLOG OF; EXO1. http://omim.org/ entry/606063 Accessed 31, Jan 2012 50. Online Mendelian Inheritance in Man. POSTMEIOTIC SEGREGATION 51. INCREASED, S. CEREVISIAE, 1; PMS1. http://omim.org/entry/600258 Accessed 31, Jan 2012 Online Mendelian Inheritance in Man. EPITHELIAL CELLULAR ADHESION MOLECULE; EPCAM. http://omim.org/ entry/185535 Accessed 31, Jan 2012 52. Online Mendelian Inheritance in Man. MutL, E. COLI, HOMOLOG OF, 3; MLH3. http://omim.org/entry/604395 Accessed 31, Jan 2012 53. Boland, C.R., Thibodeau, S.N., Hamilton, S.R., Sidransky, D., Eshleman, J.R., Burt, R.W., Meltzer, S.J., Rodriguez-Bigas, M.A., Fodde, R., Ranzani, G.N., and Srivastava, S. (1998). A National Cancer Institute Workshop on Microsatellite Instability for Developing world personalized cancer medicine 139 cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res, 58: 5248- 57. 54. Ribic, C.M., Sargent, D.J., Moore, M.J., Thibodeau, S.N., French, A.J., Goldberg, R.M., Hamilton, S.R., Laurent-Puig, P., Gryfe, R., Shepherd, L.E., Tu, D., Redston, M., and Gallinger, S. (2003). Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med, 349: 247-57. 55. Jasperson, K.W. and Burt, R.W. APC- Associated Polyposis Conditions. http:// www.ncbi.nlm.nih.gov/books/NBK1345/ Accessed 31, Jan 2012 56. Online Mendelian Inheritance in Man. APC GENE; APC. http://www.omim.org/entry/ 611731 Accessed 31, Jan 2012 57. Polakis, P. (1997). The adenomatous polyposis coli (APC) tumor suppressor. Biochim Biophys Acta, 1332: F127-47. 58. International Society for Gastrointestinal Hereditary Tumours. Colon cancer gene variant databases. http://www.insightgroup.org/mutations/ Accessed 31, Jan 2012 59. O’Neil, B.H. and Goldberg, R.M. (2008). Innovations in chemotherapy for metastatic colorectal cancer: an update of recent clinical trials. Oncologist, 13: 1074-83. 60. Hisamuddin, I.M., Wehbi, M.A., and Yang, V.W. (2007). Pharmacogenetics and diseases of the colon. Curr Opin Gastroenterol, 23: 60-6. 61. Ciccolini, J., Gross, E., Dahan, L., Lacarelle, B., and Mercier, C. (2010). Routine dihydropyrimidine dehydrogenase testing for anticipating 5-fluorouracil-related severe toxicities: hype or hope? Clin Colorectal Cancer, 9: 224-8.
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