Continuous Flow Synthesis - Selected Examples from ... - ThalesNano
Continuous Flow Synthesis - Selected Examples from ... - ThalesNano
Continuous Flow Synthesis - Selected Examples from ... - ThalesNano
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Batch Microwave Scale-Up:<br />
2-Methylbenzimidazole (200 °C, 5 min, 5 M)<br />
Temperature [°C]<br />
MW instrument<br />
Monowave 300<br />
Synthos 3000 (HF 100)<br />
200<br />
150<br />
100<br />
50<br />
0<br />
Reaction volume<br />
(mL)<br />
20<br />
16 × 60 = 960<br />
Heating Profiles<br />
Yield in g<br />
(%)<br />
9.44 (95)<br />
465.7 (98)<br />
Monowave<br />
Synthos, HF 100<br />
0 5 10 15 20 25<br />
Time [min]<br />
30 35 40 45 50<br />
Ramp/hold/cooling<br />
time (min)<br />
1/5/6<br />
15/5/30<br />
Overall processing<br />
time (min)<br />
12<br />
50
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