SATS 2009 Final Program - Scandinavian Association for Thoracic ...

S06:4
IN VITRO COMPARISON OF THE NEW IN-LINE MONITOR BMU 40 VS. THE CONVENTIONAL
LABORATORY ANALYSER ABL 700
Grosse F. Oliver 1 , Holzhey David 2 , Falk Volkmar 2 , Schaarschmidt Jan 1 , Kraemer Klaus 1 , Mohr Friedrich Wilhelm 1
1) University of Leipzig - Heart Center, Germany 2) University Hospital, Zurich, Switzerland
Background
Reliable information about different blood parameters is essential maintaining haemodynamics, perfusion and gas
exchange during CPB. For this purpose a precise and continuous monitoring is needed. The objective of this in vitro
study was to compare a novel continuous in-line blood parameter monitoring system (CIBPMS) vs. a reference
laboratory analyser.
Methods
The study was conducted as an in vitro prospective experimental study during a CPB simulation. The reliability of
BMU 40 was tested in monitoring the pO2, SO2 and Hct under physiological and extreme conditions with regards
to temperature, oxygenation and blood concentration. Four different tests were performed and conducted with five
sensors each. Correlation analyses and Bland-Altman analyses were performed.
Results
A total of 350 measurement points were compared. All monitored values of blood parameters correlated highly with
laboratory values (all r values > 0.90). Test 1: Biases of pO2(act) vary from -3.24 (±6.86) up to 6.0 (±17.89). The
biases of pO2(37°C) ranged from -3.08 (±5.53) up to 68.8 (±67.82). Test 2: The biases (SD) for Hct ranged from
-0.35 (±0.79) up to 2.35 (±0.91). The biases (SD) for SO2 vary from -0.45 (±0.86) up to 0.85 (±1.01). Test 3: The
biases (SD) of Hct ranged from -0.67 (±1.49) up to -1.00 (±1.84). Test 4: The biases (SD) for SO2 vary from -0.36
(±1.60) up to 0.48 (±0.90).
Conclusions
The BMU 40 is a reliable device in measuring the pO2, SO2 and Hct under normal physiological and extreme
conditions with regards to temperature, oxygenation and blood concentration in simulation of CPB. The algorithm to
calculate pO2(37°) under hypothermic conditions need to be adjusted.*
*In the meantime a new software version of the BMU 40 has been developed. The algorithm to calculate pO2(37°)
under hypothermic conditions has been improved and the miscalculation eliminated.
S06:5
CLINICAL EVALUATION OF THE NEW BMU 40 IN-LINE BLOOD ANALYSIS MONITOR
Schaarschmidt Jan 1 , Borger Michael Andrew 1 , Seeburger Joerg 1 , Grosse Frank Oliver 1 ,
Kraemer Klaus 1 , Mohr Friedrich Wilhelm 1
1) University of Leipzig, Heart Center, Germany
Background
Accurate information about different blood parameters is essential in maintaining haemodynamics, perfusion and
gas exchange during cardiopulmonary bypass (CPB). For this purpose a precise and continuous measurement and
monitoring, which is preferably visually available, is needed. The objective of this clinical study was to compare
the newly developed continuous in-line blood parameter monitoring system (CIBPMS) BMU 40, based on optical
luminescence and reflectance technology, with a reference laboratory analyser with regards to the precision of blood
parameters measurement.
Methods
Thirty adult patients underwent elective cardiac surgery utilizing CPB and mild hypothermia (32°C). At five
predetermined time points (S1 – S5) arterial and venous blood samples were analysed using the BMU 40 for five
different parameters (paO2(37°C), paO2(act.), SvO2, Hb(ven) and Hct(ven)) and these results were compared to
the gold standard laboratory analyser ABL 700.
Results
A total of 150 paired blood samples were included to compare means, to analyse correlation, to calculate measures
of bias, precision, limits of agreement and 95% confidence intervals. Results revealed good agreement between the
two devices for all parameters. Bias ± precision of S2 – S5 paO2(37°C) were 2.17 ± 9.61; paO2(act) 2.58 ± 9.54;
SvO2 -1.44 ± 2.35; Hb(ven) 0.01 ± 0.42; Hct(ven) 0.04 ± 1.29. Statistically significant differences were detected
for SvO2 (p