Review of Current Evidence and Comparison of Guidelines for ...
Review of Current Evidence and Comparison of Guidelines for ...
Review of Current Evidence and Comparison of Guidelines for ...
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EUR/03/5045931<br />
page 43<br />
Treponema Pallidum Immobilization test, FTAabs) should be done. If then Treponema Pallidum<br />
Immobillisation test or FTAabs are negative <strong>and</strong> clinical investigation haven’t revealed<br />
pathologic changes then test should be repeated at the age <strong>of</strong> one year, be<strong>for</strong>e getting the child<br />
removed from the registration.<br />
If at the age <strong>of</strong> three months any pathology or positive serological tests have been revealed then<br />
test should be repeated in six months at the age <strong>of</strong> one year.<br />
Children received specific treatment concerning both early <strong>and</strong> late congenital syphilis should go<br />
through clinical serological control following the same principal as the adults concerning their<br />
early <strong>and</strong> late <strong>for</strong>ms <strong>of</strong> acquired syphilis, accordingly. But this is prescribed only after a child is<br />
over one year old.<br />
Children received treatment concerning the acquired syphilis, go through clinical serology<br />
control carry out in the same way as the adults.<br />
In case <strong>of</strong> clinical or serological relapse patients are subject to inspection <strong>of</strong> therapist,<br />
neuropathologist, oculist, otolaryngologist; besides it is expedient to make a spinal puncture. The<br />
treatment is carried out following the techniques stipulated <strong>for</strong> secondary <strong>and</strong> latent syphilis,<br />
with prescription over six months.<br />
13. Ser<strong>of</strong>ast (Seroresistance) <strong>and</strong> additional treatment<br />
Seroresistance is a stable WR (or RPR) positivity preservation after full treatment concerning<br />
early stages <strong>of</strong> syphilis. Ser<strong>of</strong>ast (Seroresistance) appears when within one year after the<br />
termination <strong>of</strong> the therapy WR results with treponemal <strong>and</strong> cardiolipine antigenes or RPR results<br />
remain steady positive without the tendency to decrease in reagines titres. In these cases<br />
additional treatment is prescribed.<br />
If one year later full treatment WR (or RPR) negativation doesn’t occur, but reagines titres<br />
decrease (at least four times), or Compliment Bounding Reaction (WR) positivity degree<br />
decreases from sharply positive up to poorly positive than these cases are considered as the<br />
inhibition <strong>of</strong> seroreactions conversion is marked, <strong>and</strong> supervision is continued <strong>for</strong> six more<br />
months. If during this period the Compliment Bounding Reaction (WR) positivity still decreases<br />
then supervision can be continued <strong>for</strong> six more months. In case <strong>of</strong> no further decrease <strong>of</strong><br />
Compliment Bounding Reaction positivity additional treatment is prescribed. Thus, additional<br />
<strong>and</strong>, as a rule, unitary treatment is carried out in view <strong>of</strong> CSR dynamics in the terms <strong>of</strong> 1–2 years<br />
after the first treatment.<br />
Additional treatment should be carried out following the techniques providing high enough level<br />
<strong>of</strong> an antibiotic concentration in a body. There<strong>for</strong>e application <strong>of</strong> soluble penicillin <strong>and</strong> average<br />
lasting preparations is preferable.<br />
Method 1<br />
Treatment is carried out in a hospital by soluble penicillin in a doze 1 million. units 6 times a day<br />
within 20 days.<br />
Method 2<br />
Treatment is on an outpatient basis with procaine penicillin 1.2 million units once a day within<br />
20 days or with novocaine <strong>of</strong> penicillin 600 000 units, twice a day within 20 days.