Review of Current Evidence and Comparison of Guidelines for ...
Review of Current Evidence and Comparison of Guidelines for ...
Review of Current Evidence and Comparison of Guidelines for ...
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Table 6<br />
Congenital<br />
EUR/03/5045931<br />
page 25<br />
European Treatment Benzyl Penicillin PBP BBP if CSF normal<br />
Penicillin<br />
allergy<br />
No guidelines<br />
United<br />
Kingdom<br />
Dose 150 000 units/kg 50 000<br />
units/kg<br />
Regime Over 6<br />
doses/day<br />
50 000 units/kg<br />
od od<br />
Route IV IM IM<br />
Duration 10–14 days 10–14 days 1 day<br />
Treatment Benzyl penicillin PBP No guidelines<br />
Dose 50 000 units/kg 50 000 units/kg<br />
Regime bd then tds od<br />
Route IV IV IM<br />
Duration 7 days 3 days 10 days<br />
United States Treatment Benzyl Penicillin PBP BBP* Penicillin<br />
Desensitization<br />
Russian<br />
Federation<br />
Dose 50 000 units/kg 50 000 units/kg 50 000 units/kg<br />
Regime bd then tds od ow<br />
Route IV IV IM IM<br />
Duration 7 days 3 days 10 days 1 day<br />
Early Congenital Syphilis<br />
Penicillin<br />
allergy<br />
Treatment Benzyl penicllin NBP PBP BBP Ceftriaxone or<br />
Oxacillin or<br />
Ampicillin<br />
Dose 100 000 u/kg 50 000 u/kg 50 000 u/kg 50 000 u/kg 100 000 u/kg<br />
Regime Over 6<br />
doses/day<br />
Over 2<br />
doses/day<br />
od Ow Over 4<br />
doses/day<br />
Route IV IM IM IM IM<br />
Duration 14 days 14 days 14 days 3 weeks 14 days<br />
Only if CSF normal & not >2 kg<br />
Late congenital syphilis<br />
Treatment Benzyl Penicillin NBP PBP<br />
Penicillin<br />
allergy<br />
No guidelines<br />
Dose 50 000 u/kg 50 000 u/kg 50 000 u/kg<br />
Regime Over 6<br />
doses/day<br />
Over 2<br />
doses/day<br />
Route IV IM IM<br />
Duration 28 days, 14<br />
days <strong>of</strong>f, 14<br />
days<br />
28 days, 14<br />
days <strong>of</strong>f, 14<br />
days<br />
od<br />
28 days, 14 days <strong>of</strong>f, 14 days<br />
* Normal examination + titres, mother untreated; non penicillin regime see text <strong>of</strong> guidelines <strong>for</strong> more details