Review of Current Evidence and Comparison of Guidelines for ...
Review of Current Evidence and Comparison of Guidelines for ...
Review of Current Evidence and Comparison of Guidelines for ...
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EUR/03/5045931<br />
page 24<br />
Table 5<br />
Pregnancy<br />
Alternatives Penicillin Allergy<br />
European Treatment BBP PBP Desensitisation to<br />
penicillin<br />
United<br />
Kingdom<br />
Azithromycin Ceftriaxone<br />
Dose 2.4 MU 0.6/1.2 MU 500 mg 250–500 mg<br />
Regime ow od od Od<br />
Route IM IM po IM<br />
Duration 2 weeks 10–14 days 10 days 10 days<br />
Consider retreatment with<br />
doxycycline after breastfeeding if<br />
given above treatments<br />
Treatment PBP Erythromycin Azithromycin Desensitization<br />
to penicillin<br />
Dose 750mg 500 mg 500 mg<br />
Regime od qds od<br />
Route IM po po<br />
Duration 10 days 14 days 10 days<br />
United States As per protocol <strong>for</strong> relevant stage<br />
<strong>of</strong> disease, but possible additional<br />
dose <strong>of</strong> Benzathine Penicillin at<br />
day 8<br />
Russian<br />
Federation<br />
Up to 18 weeks<br />
gestation<br />
Treatment As per protocols<br />
<strong>for</strong> relevant<br />
stage <strong>of</strong> disease<br />
Consider retreatment with doxycycline after breastfeeding<br />
if given above treatments<br />
Post 18 weeks gestation<br />
Desensitization to penicillin<br />
Primary Secondary/<br />
early latent<br />
PBP NBP Benzyl Penicillin PBP<br />
Dose 1.2 MU 600 000units 1 million units 1.2 MU<br />
Regime od bd qds od<br />
Route IM IM IM IM<br />
Duration 10 days 10 days 10 days 20 days<br />
Penicillin Allergy<br />
As per previously described protocols but avoiding tetracycline; children are treated with penicillin at birth