Review of Current Evidence and Comparison of Guidelines for ...

EUR/03/5045931
page 24
Table 5
Pregnancy
Alternatives Penicillin Allergy
European Treatment BBP PBP Desensitisation to
penicillin
United
Kingdom
Azithromycin Ceftriaxone
Dose 2.4 MU 0.6/1.2 MU 500 mg 250–500 mg
Regime ow od od Od
Route IM IM po IM
Duration 2 weeks 10–14 days 10 days 10 days
Consider retreatment with
doxycycline after breastfeeding if
given above treatments
Treatment PBP Erythromycin Azithromycin Desensitization
to penicillin
Dose 750mg 500 mg 500 mg
Regime od qds od
Route IM po po
Duration 10 days 14 days 10 days
United States As per protocol for relevant stage
of disease, but possible additional
dose of Benzathine Penicillin at
day 8
Russian
Federation
Up to 18 weeks
gestation
Treatment As per protocols
for relevant
stage of disease
Consider retreatment with doxycycline after breastfeeding
if given above treatments
Post 18 weeks gestation
Desensitization to penicillin
Primary Secondary/
early latent
PBP NBP Benzyl Penicillin PBP
Dose 1.2 MU 600 000units 1 million units 1.2 MU
Regime od bd qds od
Route IM IM IM IM
Duration 10 days 10 days 10 days 20 days
Penicillin Allergy
As per previously described protocols but avoiding tetracycline; children are treated with penicillin at birth