Review of Current Evidence and Comparison of Guidelines for ...

Table 4
Neurosyphilis
EUR/03/5045931
page 23
European Alternatives Penicillin Allergy
United
Kingdom
Treatment Benzyl Penicillin Benzyl
Penicillin
Dose 2-4 MU 0.15
MU/kg/day
Regime over 6
doses/day
over 6
doses/day
PBP + Probenecid Doxycycline
1.2–2.4 MU/500
mg
200 mg
od/qds bd
Route IV IV IM/po po
Duration 10–21 days 10–14 days 10–21 days 28–30 days
Treatment PBP + Probenecid Benzyl Penicillin Doxycycline
Dose 2g/500 mg 18–24 MU 200 mg
Regime od/qds Over 6 doses/day bd
Route IM/po IV po
Duration 17 days 17 days 28 days
United States Treatment Benzyl Penicillin PBP + Probenecid Ceftriaxone Or penicillin
desensitization
Dose 18–24 MU 2.4 MU/500 mg 2 g
Russian
Federation
Regime Over 6
doses/day or
cont infusion
od/qds od
Route IV IM/po IM/IV
Duration 10–14 days 10–14 days 10–14 days
Early visceral neurosyphilis Early Neurosyphilis
Treatment Benzyl Penicillin NBP Benzyl Penicillin Benzyl
Penicillin
Dose 1 MU 0.6 MU 10 MU 2 MU
Regime qds bd bd 6/day
Route IM IM IV IV
Duration 20 days 20 days 14 days 14 days
Late Visceral Neurosyphilis
Penicillin
Allergy
Treatment Benzyl Penicillin NBP PBP Ceftriaxone
Dose 0.4 MU 0.6 MU 1.2 MU 1–2 g (up to 4 g)
Regime 8/day bd od od
Route IM IM IM IM/IV
Duration 28 days, 14
days off, 28
days
28 days, 14
days off, 28
days
42 days, 14 days
off, 14 days
14 days