Review of Current Evidence and Comparison of Guidelines for ...
Review of Current Evidence and Comparison of Guidelines for ...
Review of Current Evidence and Comparison of Guidelines for ...
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Tables<br />
Table 1<br />
Abbreviation<br />
used in this<br />
paper<br />
Benzyl<br />
Penicillin<br />
Names given<br />
in different<br />
papers<br />
Benzyl<br />
Penicillin<br />
SBP<br />
BBP Benzathine<br />
Penicillin<br />
Extencillin<br />
Retarpen<br />
Bicillin-1<br />
PBP Procaine<br />
Penicillin<br />
NBP Novocaine<br />
salt<br />
Summary <strong>of</strong> Different Penicillin Preparations<br />
Components Equivalent<br />
dose <strong>for</strong> 1<br />
million units<br />
benzyl<br />
penicillin<br />
Penicillin G<br />
Potasium or<br />
Penicillin G<br />
Sodium<br />
Benzathine<br />
Penicillin G<br />
Procaine<br />
Penicillin G<br />
Procaine<br />
Penicillin with<br />
novocaine salt<br />
Bicillin -3 Bicillin -3 BBP, Benzyl<br />
Pen, NBP in<br />
1:1:1 ratio<br />
Bicillin -5 Bicillin -5 BBP, NBP in<br />
1:4 ratio<br />
Peak concentration<br />
(time after IM<br />
injection)<br />
EUR/03/5045931<br />
page 19<br />
Duration <strong>of</strong> action CSF<br />
penetration<br />
600 mg 15–30 min t1/2 = 30min good<br />
750 mg 240 min Detectable in<br />
plasma <strong>for</strong> 4<br />
weeks<br />
1020 mg 60–240 min Effective<br />
concentrations in<br />
plasma <strong>for</strong><br />
12–24 hours<br />
1020 mg Shorter acting<br />
than PBP, so<br />
given bd instead<br />
<strong>of</strong> od<br />
n/a n/a Intermediate<br />
n/a n/a Intermediate<br />
poor<br />
poor<br />
poor
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